A5100612676- Bone Metabolism and Diseases
- Insect Resistance and Genetics
- Bone health and treatments
- High Altitude and Hypoxia
- Underwater Vehicles and Communication Systems
- Mosquito-borne diseases and control
- Drug Transport and Resistance Mechanisms
- Studies on Chitinases and Chitosanases
- Nanocomposite Films for Food Packaging
- Inertial Sensor and Navigation
- Genetic and phenotypic traits in livestock
- Bone health and osteoporosis research
- Skin Protection and Aging
- Neuroscience of respiration and sleep
- Antioxidant Activity and Oxidative Stress
- RNA regulation and disease
- ATP Synthase and ATPases Research
- Protein Interaction Studies and Fluorescence Analysis
- Retinoids in leukemia and cellular processes
- Cardiovascular and Diving-Related Complications
- MicroRNA in disease regulation
- Medicinal plant effects and applications
- Connexins and lens biology
- Connective tissue disorders research
- Lipid metabolism and biosynthesis
Guangdong Ocean University
2023-2025
East China University of Science and Technology
2017-2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2019-2023
Qilu Hospital of Shandong University
2023
Huazhong University of Science and Technology
2017-2022
Zhejiang University
2022
Tongji Hospital
2017-2022
Gansu Agricultural University
2022
Tibet Autonomous Region People's Hospital
2022
Beijing Fengtai Hospital
2020
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage bone destruction. Nuclear receptor subfamily 1 group D member (NR1D1) functions as transcriptional repressor plays vital role in inflammatory reactions. However, whether NR1D1 involved inflammation joint destruction during the pathogenesis of RA unknown. In this study, we found that expression was increased tissues from patients with decreased Fibroblast-like...
Osteoporosis is a highly prevalent disease which has been major public health problem and considered to be associated with chronic low-grade systemic inflammation oxidative damage. Taxifolin natural flavonoid possesses many pharmacological activities including antioxidant anti-inflammatory. Because flavonoids have confirmed fight osteoporosis promote bone health, the aim of this study was investigate effects taxifolin on formation function osteoclast. In study, we examined osteoclast using...
Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use insecticides one ways to control this medically important insect pest. However, few new have been developed for mosquito in recent years. As a part our effort develop mosquitoes, an inhibitor apoptosis protein 1 gene (AaeIAP1) was targeted development molecular pesticides. Herein, first time, we report that topically applied AaeIAP1 double-stranded RNA products are able kill female adults Ae....
Against the backdrop of a changing global climate, soil environment may undergo significant changes, directly affecting agricultural productivity and exacerbating food security issues. Three different substrates were set up in this study, namely, S (high sand low nutrient content), T (medium medium TT (low high content). The results showed that root/shoot ratio increased as content (nutrient decreased). Rice had various degrees dependence on antioxidant enzymes antioxidants. For example,...
Abstract Destructive bone diseases caused by osteolysis are increasing in incidence. They characterized an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation nuclear factor‐κB (NF‐κB) mitogen‐activated protein kinase (MAPK) signaling pathways triggered receptor activator NF‐κB ligand (RANKL), inflammatory factors, oxidative stress. Previous studies have indicated that common flavanone glycoside compound hesperetin exhibits anti‐inflammatory...
REV-ERBs (REV-ERBα and REV-ERBβ) are transcription repressors circadian regulators. Previous investigations have shown that repress the expression of target genes, including MMP9 CX3CR1, in macrophages. Because CX3CR1 reportedly participate receptor activator nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis, we inferred might play a role osteoclastogenesis. In present study, found REV-ERBα level decreased significantly during RANKL-induced osteoclast differentiation from primary...
Temperature is important for mosquito development and physiological response. Several genes of heat shock protein (HSP) families are known to be expressed in mosquitoes may crucial responding stress induced by elevated temperature. Suppression subtractive hybridization (SSH) was used identify target transcripts treatment female Aedes aegypti. Subtraction performed both directions enriching cDNAs differentially between a non-heat control treatment. Heat Ae. aegypti carried out 1 h at 42°C....
The East Friesian sheep is one of the important high-yielding dairy breeds, but still little known about their genetic and genomic variation during domestication. Therefore, we analyzed data 46 with aim identifying candidate genes that are closely related to milk production traits. Our consisted 20 26 Asian Mouflon wild sheep. Finally, a total 32590241 SNPs were identified, which 0.61% (198277) located in exonic regions. After further screening, 122 shared regions top 1% FST Nucleotide...
Dihydromyricetin (DMY), the main flavonoid component of Ampelopsis grossedentata, possesses pharmacological activities useful for treatment diseases associated with inflammation and oxidative damage. Because osteoclasts are often involved in chronic low-grade systemic damage, we hypothesized that DMY may be an effective osteoclast-related diseases. The effects on osteoclast formation activity were examined vitro. Female C57BL/6 mice ovariectomized to mimic menopause-induced bone loss treated...
Progressive bone loss during aging makes osteoporosis one of the most common and life impacting conditions in geriatric populations. The homeostasis is maintained through persistent remodeling mediated by bone-forming osteoblast bone-resorbing osteoclast. Inflammaging, a condition characterized increased pro-inflammatory markers blood other tissues aging, has been reported to be associated with skeletal stem/progenitor cell dysfunction, which will result impaired formation. However, role...
Abstract and Aim: Cholangiocarcinoma (CCA) is a highly aggressive lethal cancer that originates from the biliary epithelium. Systemic treatment options for CCA are currently limited, first targeted drug of CCA, pemigatinib, emerged in 2020 by inhibiting FGFR2 phosphorylation. However, regulatory mechanism phosphorylation not fully elucidated. Approach Results: Here we screened FGFR2-interacting proteins showed protein tyrosine phosphatase (PTP) N9 interacts with negatively regulates...
Cytochrome c is a highly conserved protein that found in many multicellular and unicellular organisms. critical intermediate apoptosis: controlled form of cell death kills cells as part their natural process development response to environmental condition. To detect whether cytochrome the mosquito Aedes aegypti (L.) (AeaCytC) developmentally regulated, we used quantitative real-time polymerase chain reaction (PCR) examine AeaCytC gene expression levels different developmental stages Ae....
Real-time status monitoring is an important prerequisite for coral reef ecological protection. Existing equipment does not provide ocean observation platform with adequate mobility and efficiency. This paper describes the design considerations of a proposed autonomous underwater helicopter (AUH) dedicated reefs, including system architecture, electronic devices, sensors actuators, explains path control algorithm controller to follow specific exploration. The structure dynamic model AUH are...
Short-term, high altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left ventricular volumes. However, relatively little is known of the long-term cardiac consequences prolonged in Chinese Han lowlanders, a highly adapted HA population.We studied structure function by echocardiography to investigate short-term adaptation potential remodeling.This study included 301 healthy subjects (STE), acclimatized lowlanders (AL) at HA, native Tibetans (NT), sea level...
This study explored the lipid-lowering effect and intervention mechanism of alginate oligosaccharides (AOS) on non-alcoholic fatty liver disease (NAFLD). Results showed that both unsaturated (UAOS) saturated (SAOS) AOS improved hepatic steatosis NAFLD mice fed a high-fat diet (HFD). promoted lipid catabolism in vivo vitro by activating lipophagy free acid (FFA) β-oxidation pathways. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) represented up-stream target FFA pathway...
Magnesium is crucial for baculovirus transmission in Culex nigripalpus (Theobald) and quinquefasciatus (Say) larvae. However, the mechanistic role of magnesium unknown. To investigate possible host response factors transmission, suppression subtractive hybridization was used to identify genes differentially transcribed after exposure Cx. Suppression performed both directions enriching cDNAs between a nonmagnesium larval control (15 mM MgSO4) treatment larvae held 1 h at 27 degrees C. Clones...