A5082689116- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Microbial infections and disease research
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Effects of Environmental Stressors on Livestock
- Vibrio bacteria research studies
- Milk Quality and Mastitis in Dairy Cows
- Ruminant Nutrition and Digestive Physiology
- RNA modifications and cancer
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- Heavy metals in environment
- Brucella: diagnosis, epidemiology, treatment
- Livestock Farming and Management
- Plant Micronutrient Interactions and Effects
- Burkholderia infections and melioidosis
- Escherichia coli research studies
- Hepatitis C virus research
- Influenza Virus Research Studies
- Adsorption and biosorption for pollutant removal
- Herpesvirus Infections and Treatments
Lanzhou Veterinary Research Institute
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Lanzhou University
2021-2024
Ministry of Agriculture and Rural Affairs
2024
Gansu Agricultural University
2021
Nanjing Agricultural University
2013-2019
Because membrane fusion is a crucial step in the process by which enveloped viruses invade host cells, inhibitors can be effective drugs against viruses. We found that surfactin from Bacillus subtilis suppress proliferation of porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis (TGEV) epithelial cells at relatively low concentration range (15 to 50 μg/ml), without cytotoxicity or viral disruption. Membrane inhibition experiments demonstrate treatment significantly...
Heritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen interactions and their association with phenotype in sheep. To solve this, we curated analyzed whole-genome resequencing genotypes, 16S rumen-microbiota data, longitudinal body weight (BW) phenotypes from 1150 sheep.A variance component model indicated significant heritability microbial community diversity. Genome-wide studies (GWAS) using...
Surfactin has antiviral activity against various enveloped viruses by inhibiting viral membrane fusion. However, the potential utility of surfactin as an drug is limited its cytotoxicity. In this study, 10 analogues were obtained chemical synthesis and evaluated to determine their anti-PEDV activities, hemolytic critical micelle concentrations. The main goal our study was develop a safer drug; analogue with high low activity. Compared surfactin, one we developed, SLP5, lower activity, same...
The abundance of domesticated sheep varieties and phenotypes is largely the result long-term natural artificial selection. However, there limited information regarding genetic mechanisms underlying phenotypic variation induced by domestication improvement sheep. In this study, to explore genomic diversity selective regions at genome level, we sequenced genomes 100 across 10 breeds combined these results with publicly available data from 225 individuals, including improved breeds, Chinese...
Swine extraintestinal pathogenic Escherichia coli (ExPEC) is an important pathogen that leads to economic and welfare costs in the swine industry worldwide, occurring with increasing frequency China. By far, various virulence factors have been recognized ExPEC. Here, we investigated genotypes clonal structure of collected strains improve knowledge phylogenetic traits porcine ExPECs China.We isolated 64 Chinese ExPEC from 2013 14 multiplex PCR, distribution isolates belonging groups B1, B2, A...
Abstract Improving feed efficiency would increase profitability for producers. The objective of this study was to detect the expression levels ME1 and CA1 polymorphisms associated with conversion ratio (FCR) residual intake (RFI) Hu sheep by using qRT‐PCR, pooled DNA sequencing KASPar assay. qRT‐PCR results indicated that were significantly higher in liver tissues low‐RFI than those high‐RFI ( p <.01). Association analysis demonstrated polymorphism g.453 C > T FCR RFI <.05). g.199...
Streptococcus suis is an important swine pathogen that can cause a variety of diseases. serotype 9 (SS9) prevalent serotype, but limited information available. Here, we studied and compared 30 SS9 isolates, including 24 isolates from China between year 2004 2013, 5 Vietnam reference isolate Denmark. A multilocus sequence typing (MLST) analysis was performed to exploit the genetic relationships those isolates. The phylogenetic tree based on MLST data divides into two clades (I II), revealing...
Mastitis caused by Staphylococcus aureus (S. aureus) in dairy cows is one of the most common clinical diseases cattle. Unfortunately, traditional antibiotic treatment has resulted emergence drug-resistant strains bacteria, making this disease more difficult to treat. Therefore, novel lipopeptide antibiotics are becoming increasingly important treating bacterial diseases, and developing critical controlling mastitis cows. We designed synthesized three cationic lipopeptides with palmitic acid,...
Brucellosis, caused by the intracellular pathogen
The present study aimed to investigate the relationship between growth performance, body composition, and fat deposition factors, feed efficiency in growing lambs. We measured average daily intake (ADFI) weight (BW) from 653 Hu sheep that were fed a pellet diet. residual (RFI) not significantly genetic phenotypic correlated with metabolic (MBW) gain (ADG), but it was ADFI conversion ratio (FCR) (p < 0.01). However, FCR associated traits With same ADG, greater animals low compared high...
The East Friesian sheep is one of the important high-yielding dairy breeds, but still little known about their genetic and genomic variation during domestication. Therefore, we analyzed data 46 with aim identifying candidate genes that are closely related to milk production traits. Our consisted 20 26 Asian Mouflon wild sheep. Finally, a total 32590241 SNPs were identified, which 0.61% (198277) located in exonic regions. After further screening, 122 shared regions top 1% FST Nucleotide...
Transmissible gastroenteritis virus (TGEV), the etiologic agent of transmissible gastroenteritis, infects swine all ages causing vomiting and diarrhea, in newborn piglets mortality rate is near 100%. Intestinal epithelial cells are primary target TGEV. Transferrin receptor 1 (TfR1), which highly expressed with anemia, may play a role TGEV infection. However, underlying mechanism invasion remains largely unknown.Our study investigated possibility that TfR1 can serve as for infection enables...
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting...
Herein we detected single nucleotide polymorphisms in MEF2B and UCP3 by DNA sequencing the KASPar technology analyzed their association with sheep growth traits. Two synonymous mutations, g.1826 C > T g.10266 G C, were detected, respectively, they found to be significantly associated traits (p < 0.05). In case of T, average body weight chest cannon circumference CC genotype higher than those CT TT genotypes Moreover, GG GC CC/GG was compared other combinations. We also assessed expression...
The H7N9 subtype influenza A viruses pose a serious threat to public health, and there is still lack of vaccines or drugs for humans against viruses. In this study, we screened two monoclonal antibodies (MAbs), 4H1E8 7H9A6, that specifically recognize the hemagglutinin (HA) protein virus display highly neutralizing activity virus. epitopes recognized by MAbs are nearly all conserved within known H7 subtypes. Characteristic identification showed have high avidity HA but no inhibition...