A5027101814- SARS-CoV-2 and COVID-19 Research
- melanin and skin pigmentation
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
- Skin Protection and Aging
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Atomic and Subatomic Physics Research
- Biochemical Analysis and Sensing Techniques
- Cancer Immunotherapy and Biomarkers
- Physiological and biochemical adaptations
- Yersinia bacterium, plague, ectoparasites research
- Food Allergy and Anaphylaxis Research
- Chromatin Remodeling and Cancer
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Molecular Biology Techniques and Applications
- Protein Tyrosine Phosphatases
- Metabolism, Diabetes, and Cancer
University of Pennsylvania
2020-2024
California University of Pennsylvania
2021-2024
Peking University
2014-2021
Center for Life Sciences
2015-2020
Diabetic cardiomyopathy, which contributes to >50% diabetic death, is featured by myocardial lipid accumulation, hypertrophy, fibrosis, and cardiac dysfunction. The mechanism underlying cardiomyopathy poorly understood. Recent studies have shown that a striated muscle-specific E3 ligase Mitsugumin 53 (MG53, or TRIM72) constitutes primary causal factor of systemic insulin resistance metabolic disorders. Although it most abundantly expressed in myocardium, the biological pathological roles...
The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that affects global Cohesin binding genome structures. However, several other indicated inhibited does not alter conformations.
Abstract Though vascular smooth muscle cell (VSMC) proliferation underlies all cardiovascular hyperplastic disorders, our understanding of the molecular mechanisms responsible for this cellular process is still incomplete. Here we report that SRSF1 (serine/arginine-rich splicing factor 1), an essential factor, promotes VSMC and injury-induced neointima formation. Vascular injury in vivo proliferative stimuli vitro stimulate expression. Mice lacking specifically SMCs develop less intimal...
Human genomic diversity has been shaped by both ancient and ongoing challenges from viruses. The current coronavirus disease 2019 (COVID-19) pandemic caused severe acute respiratory syndrome 2 (SARS-CoV-2) had a devastating impact on population health. However, genetic evolutionary forces impacting host genes related to SARS-CoV-2 infection are not well understood. We investigated global patterns of variation signatures natural selection at relevant (angiotensin converting enzyme [ACE2],...
Phosphatidylinositol 3 kinases (PI3Ks) play a pivotal role in vascular physiology and pathophysiology. We aimed to investigate the of p55γ, regulatory subunit PI3Ks, smooth muscle cell (VSMC) proliferation neointimal formation. identified p55γ as an important factor that suppresses VSMC injury-evoked Western blot mRNA analyses showed expression declined balloon-injured rat carotid arteries response PDGF-BB serum treatment cultured VSMCs. Overexpression inhibited, whereas short hairpin RNA...
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting...
Cis-regulatory elements play important roles in tissue-specific gene expression and the evolution of various phenotypes, mutations promoters enhancers may be responsible for adaptations species to environments. TRIM72 is a highly conserved protein that involved energy metabolism. Its heart varies considerably primates, with high levels Old World monkeys near absence hominids. Here, we combine phylogenetic hypothesis testing experimentation demonstrate promoter are differences among primate...
We investigated global patterns of genetic variation and signatures natural selection at host genes relevant to SARS-CoV-2 infection ( ACE2, TMPRSS2, DPP4 , LY6E ). analyzed novel data from 2,012 ethnically diverse Africans 15,997 individuals European African ancestry with electronic health records, integrated the 1000GP. At ACE2 we identified 41 non-synonymous variants that were rare in most populations, several which impact protein function. However, three common among Central...
This protocol was designed for the workflow of Multiome assay on 16 PBMC samples using 10X Next GEM Single Cell ATAC + Gene Expression Kit. We adapted Jimmy Ye Lab's pooling and demultiplexing strategy, overloading cells in each well. For step this protocol, you may need genotyping information your samples.
Abstract We investigated global patterns of genetic variation and signatures natural selection at host genes relevant to SARS-CoV-2 infection ( ACE2, TMPRSS2, DPP4, LY6E ). analyzed novel data from 2,012 ethnically diverse Africans 15,997 individuals European African ancestry with electronic health records, integrated the 1000GP. At we identified 41 non-synonymous variants that were rare in most populations, several which impact protein function. However, three common among Central...
<ns3:p>In October 2019, 46 scientists from around the world participated in first National Center for Biotechnology Information (NCBI) Structural Variation (SV) Codeathon at Baylor College of Medicine. The charge this annual working session was to identify ongoing challenges topics SV and graph genomes, response design reliable methods facilitate their study. Over three days, seven groups each designed developed new open-sourced improve bioinformatic analysis genomic SVs represented...