A5048075686- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- dental development and anomalies
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Adipose Tissue and Metabolism
- Dental materials and restorations
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Ion channel regulation and function
- Protein Kinase Regulation and GTPase Signaling
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Aldose Reductase and Taurine
- Nasal Surgery and Airway Studies
- Radiation Effects and Dosimetry
- Orthodontics and Dentofacial Orthopedics
- Tracheal and airway disorders
Sichuan University
2015-2025
State Key Laboratory of Oral Diseases
2014-2024
The University of Texas Health Science Center at Houston
2013-2023
Stanford Medicine
2014-2022
Stanford University
2015-2022
University of Houston
2011-2019
Tianjin People's Hospital
2015
Hallym University Medical Center
2014-2015
Wannan Medical College
2014
Texas Medical Center
2011-2013
Abstract Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular components are selectively digested for the recycling of nutrients and energy. This process indispensable cell homeostasis maintenance stress responses. Both genetic functional studies have demonstrated that multiple proteins involved autophagic activities critical to survival, differentiation, functioning bone cells, including osteoblasts, osteocytes, osteoclasts. Dysregulation at level...
Implants placed with high insertion torque (IT) typically exhibit primary stability, which enables early loading. Whether IT has a negative impact on peri-implant bone health, however, remains to be determined. The purpose of this study was ascertain how responds strains and stresses created when implants are low IT. Titanium micro-implants were inserted into murine femurs using values that scaled approximate those used place clinically sized implants. Torque in tissues distribution...
With heart failure leading the cause of death in USA (Hunt), biomedical research is fundamental to advance medical treatments for cardiovascular diseases. Animal models that mimic human cardiac disease, such as myocardial infarction (MI) and ischemia-reperfusion (IR) induces well pressure-overload (transverse aortic constriction) hypertrophy (Goldman Tarnavski), are useful study disease. In particular, ischemia a morbidity mortality despite controlling certain risk factors arteriosclerosis...
A variety of clinical classification schemes have been proposed as a means to identify sites in the oral cavity where implant osseointegration is likely be successful. Most are based on structural characteristics bone, for example, relative proportion densely compact, homogenous (type I) bone versus more trabeculated, cancellous III) bone. None these schemes, however, consider potential biological Here, we employed multiscale analyses and characterize type I III bones murine jaws. We then...
Re-establishing compromised periodontium to its original structure, properties and function is demanding, but also challenging, for successful orthodontic treatment. In this study, the periodontal regeneration capability of collagen-hydroxyapatite scaffolds, seeded with bone marrow stem cells, was investigated in a canine labial alveolar defect model. Bone cells were isolated, expanded characterized. Porous scaffold cross-linked prepared. Attachment, migration, proliferation morphology...
Corticotomy is an effective approach in accelerating orthodontic tooth movement (OTM) clinical treatment. causes regional acceleratory phenomenon (RAP) the alveolar bone of surgical sites. However, molecular mechanism RAP after corticotomy remains unclear. Herein, we established a mouse model to study biomechanical interfaces corticotomy-assisted OTM and investigate histological responses underlying cellular mechanism. A total 144 male C57BL/6 mice were randomly assigned into four groups:...
It remains a challenge to achieve satisfactory balance between biodegradability and osteogenic capacity in biosynthetic bone grafts. In this study, we aimed address by incorporating mesoporous bioactive glass (MBG) into poly(caprolactone-co-glycolide) (PGA-PCL) at gradient ratios. MBG/PGA-PCL (PGC/M) scaffolds with MBG incorporation ratio 0, 10%, 25% 40% (PGC/M0-40) were synthesized using modified solvent casting-particulate leaching method, their physiochemical biological properties...
Vanadium is a bioactive trace element with variable valence. Its pentavalent form has been confirmed to be capable of predominantly regulating the early and mid-stage osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) without tumor inhibition, while its tetravalent exhibits inhibition but only primarily modulates late angiogenesis. In this study, multifunctional tissue scaffold consisting mixed-valence vanadium-doped mesoporous glass poly(lactic-co-glycolic acid)...
The molecular signals responsible for maintaining homeostatic control over the periodontal ligament (PDL) are unknown. purpose of this study is to investigate role Wnt signaling in process using gain- and loss-of-function approaches.The function endogenous signal PDL was evaluated Lrp5(ACT) mice which a mutation low-density lipoprotein receptor-related protein 5 coreceptor causes constitutive activation signaling, adenovirus Dkk1-treated overexpression inhibitor Dkk1 transient inhibition....
Abstract Background This study aims to develop a novel process establish standardized manufacturing technique of customized esthetic ceramic bracket system (CCB) which could be endowed with individual color and shape satisfy patients’ demands. Material characteristics mechanical parameters CCB were evaluated. Subjects methods virtual models designed individually according patient’s teeth morphology clinical 3D printing technology, lost-wax selected glass-ceramic ingots employed fabricate...
Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement, bone resorption, and loss during orthodontic treatment. Promoting formation reducing resorption are strategies for controlling these complications. For several decades, the autophagy inducer lithium chloride (LiCl) has been explored bipolar . In this study, we investigated autophagy-promoting effect of LiCl on remodeling under osteoporotic conditions movement. Ovariectomy was used to...
Stroke is a life-changing event as stroke survivors experience changes in personality, emotions and mood. We investigated the effect of xenon gas encapsulated liposomes on stroke-generated sensorimotor impairments, anxiety- depression-like phenotypes. Ischemic was created by intraluminal middle cerebral artery occlusion (MCAO) for 6 h followed reperfusion rats. Xenon-liposome (6 mg/kg, intravenous) treatment given multiple times starting at 2 post-ischemia through (5X), once-daily next 3...
The osseointegration of dental implants is impaired in patients with osteoporosis, leading to significantly higher failure rates. This study set out investigate the potential effects alpha-ketoglutarate (α-KG) on implant an osteoporotic mouse model.Female C57BL/6 mice received ovariectomy and bilateral first maxillary molar extraction at age 7 weeks. Dental were inserted 8 weeks after tooth extraction. In one groups, α-KG was administered via drinking water throughout experimental period....
Orthodontically induced tooth root resorption (OIRR) is a serious complication during orthodontic treatment. Stimulating cementum repair the fundamental approach for treatment of OIRR. Parathyroid hormone (PTH) might be potential therapeutic agent OIRR, but its effects still lack direct evidence, and underlying mechanisms remain unclear. This study aims to explore involvement long noncoding RNAs (lncRNAs) in mediating anabolic intermittent PTH contributing repair, as identifying...