A5081261991- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Pediatric health and respiratory diseases
- Estrogen and related hormone effects
- Metastasis and carcinoma case studies
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Esophageal Cancer Research and Treatment
- Macrophage Migration Inhibitory Factor
- Biosimilars and Bioanalytical Methods
- Gastrointestinal Tumor Research and Treatment
- DNA Repair Mechanisms
- RNA Research and Splicing
- Galectins and Cancer Biology
Zhengzhou People's Hospital
2014-2025
Henan University
2023
Southern Medical University
2007-2021
Zhujiang Hospital
2007
Accumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important regulatory role in cancers. However, the expression and biological functions of colorectal cancer (CRC) are still unclear. In present study, we determined CRC explored function on cell progression. The results showed was significantly increased tissues lines; high associated with depth invasion, lymph node metastasis, TNM stage patients. Kaplan‐Meier curve analysis patients had a poor overall...
The aim of the study was to research biological functions circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug-resistant cell lines (HT29-LOHP, HCT116-LOHP, HCT8-LOHP) were separately dealt with oxaliplatin concentration gradient (0.1-10 μmol/L). Real-time PCR, Western blotting, dual-luciferase assay, miRNA pull-down coimmunoprecipitation ELASA performed explore chemotherapy drug resistance CRC. results showed that expression hsa_circ_0079662 increased...
To the Editor: Chemotherapy is one of mainstay therapies for patients with breast cancer (BC),[1,2] but it often restricted by dose-limiting toxicities attributed to myelosuppression. Although recombinant human granulocyte colony-stimulating factors (rhG-CSF) are effective treating and preventing chemotherapy-induced neutropenia, daily administration inconvenient patients.[3,4] Telpegfilgrastim (Peijin®, Xiamen Amoytop Biotech Co., Ltd, Xiamen, China) a Y-shape branched pegylated factor...
Abstract Background Chemotherapy-induced neutropenia (CIN) is usually managed by recombinant human granulocyte colony stimulating factor (rhG-CSF) and pegylated rhG-CSF (PEG-rhG-CSF). This study evaluated the efficacy safety of telpegfilgrastim, a novel Y-shaped PEG-rhG-CSF, for CIN prophylaxis in patients with non-small cell lung cancer (NSCLC). Methods was multicentre, randomized, open-label, active-controlled non-inferiority study. Patients NSCLC who received 1–4 chemotherapy cycles...
Cisplatin (DDP) resistance is a huge obstacle to gastric cancer (GC) treatment. Long non-coding RNAs (lncRNAs) have been manifested exert pivotal functions in GC development. Herein, we aimed explore the functional impact of lncRNA small nucleolar RNA host gene 6 (SNHG6) on DDP and progression GC. Quantitative real-time PCR (qRT-PCR) assay or Western blotting was performed detect expression SNHG6, microRNA(miR)-1297, epithelial-mesenchymal transition (EMT)-related factors B-Cell Lymphoma 2...
Long non‑coding RNAs have been reported to be involved in non‑small cell lung cancer (NSCLC) progression. However, whether Opa‑interacting protein 5 antisense RNA 1 (OIP5‑AS1) serves a role NSCLC remains unclear. Bioinformatics analysis of The Cancer Genome Atlas datasets showed clinical significance and relevance OIP5‑AS1 NSCLC. Western blotting reverse transcription‑quantitative PCR revealed protein RNA expression levels the genes [including <em>OIP5‑AS1</em>, microRNA...
We aimed to investigate miRNAs and related mRNAs through a network-based approach in order learn the crucial role that they play biological processes of esophageal cancer. Esophageal squamous-cell carcinoma (ESCC) adenocarcinoma (EAC)-related miRNA gene expression data were downloaded from Gene Expression Omnibus database, differentially expressed genes selected. Target predicted their regulatory networks constructed. Differentially analysis selected four associated with EAC ESCC, among...
We did a case-control study to provide more comprehensive evaluation of the association pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed primary cancer control subjects were recruited at Zhengzhou People's Hospital. For SNP genotyping, we used Assay Designer 3.1 design primers polymerase chain reaction. Using chi-square test, found that likely be alcohol drinkers (χ(2) = 4.4, P 0.04), have family history in first...
Mucinous adenocarcinoma is an unusual histological type of lung cancer, and its clinicopathological feature distinctive from that other histopathological types adenocarcinoma. has a mucus-producing function, which explains name. The present study reports rare case the lung. A 60-year-old Chinese female patient was diagnosed with mucinous lung, manifested as respiratory symptoms, including fever, cough expectoration. received thoracic exploratory operation right pneumonectomy, since above...
We examined the effects and molecular mechanism of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells cytotoxicity cytokine-induced killer cells.Flow cytometry was used to detect under EGFR downstream molecules, including LY294002 (phosphoinositide 3-kinase inhibitor), SB203580 (mitogenactivated protein STAT21 (signal transduction transcription 3 inhibitor) after 24 h.A lactate dehydrogenase release...
We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in ERCC5 gene (rs1047768, rs751402, and rs17655) risk of developing gastric cancer. Between January 2013 December 2014, samples were collected from 216 cancer patients control subjects. rs1047768, rs17655 polymorphisms genotyped by polymerase chain reaction combined with restriction fragment length polymorphism analysis. By conditional logistic regression analysis, GG genotype was found be...
Gastrointestinal stromal tumors (GISTs) are rare, and account for 1% of all gastrointestinal neoplasms. GISTs the most frequent mesenchymal tract. However, clinical pathological characteristics these neoplasms not adequately understood. The best treatment approach remains unclear. In present study, we report a case GIST originating from stomach. A digestive tract hemorrhage occurred as complication sunitinib treatment. This is first due to
To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.The 40 cases esophagus carcinoma corresponding normal mucosa tissues were examined by immunohistochemistry.The positive rate protein was 75.0% (30/40), that 0 (0/40). Up-regulation found carcinomas. The related histological grade (P = 0.012).MICA/B plays an important role carcinogenesis, my become a useful molecular marker for diagnosis carcinoma.
PURPOSE Mixed formulation of fosrolapitant and palonosetron (PALO), HR20013, is a novel fixed-dose intravenous antiemetic combination that could simultaneously antagonize neurokinin-1 5-hydroxytryptamine-3 receptors. This study was designed to evaluate the efficacy safety HR20013 plus dexamethasone (DEX) versus fosaprepitant (FAPR) PALO + DEX for preventing chemotherapy-induced nausea vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC). METHODS noninferiority study....
To explore the expression of major histocompatibility complex classⅠchain-related protein A and B (MICA/B) in operable lung adenocarcinoma its clinical significance.Between January 2002 December 2003, 100 patients with People's Hospital Zhengzhou were collected. The MICA/B was examined by immunohistochemistry staining.According to immunohistochemical staining, cases score ≥5 points high while <5 low MICA/B.Chi-square test utilized analyze relationship between clinicopathologic features....