A5019644212- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Nerve injury and regeneration
- Macrophage Migration Inhibitory Factor
- Cancer Mechanisms and Therapy
- Parathyroid Disorders and Treatments
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Bone health and treatments
- Myasthenia Gravis and Thymoma
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Peking Union Medical College Hospital
2024-2025
Zhengzhou People's Hospital
2015-2020
Southern Medical University
2020
The aim of the study was to research biological functions circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug-resistant cell lines (HT29-LOHP, HCT116-LOHP, HCT8-LOHP) were separately dealt with oxaliplatin concentration gradient (0.1-10 μmol/L). Real-time PCR, Western blotting, dual-luciferase assay, miRNA pull-down coimmunoprecipitation ELASA performed explore chemotherapy drug resistance CRC. results showed that expression hsa_circ_0079662 increased...
We examined the effects and molecular mechanism of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells cytotoxicity cytokine-induced killer cells.Flow cytometry was used to detect under EGFR downstream molecules, including LY294002 (phosphoinositide 3-kinase inhibitor), SB203580 (mitogenactivated protein STAT21 (signal transduction transcription 3 inhibitor) after 24 h.A lactate dehydrogenase release...
To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.The 40 cases esophagus carcinoma corresponding normal mucosa tissues were examined by immunohistochemistry.The positive rate protein was 75.0% (30/40), that 0 (0/40). Up-regulation found carcinomas. The related histological grade (P = 0.012).MICA/B plays an important role carcinogenesis, my become a useful molecular marker for diagnosis carcinoma.
Abstract ENPP1 depletion closely related with modulation immunotherapy of several types cancer. However, the role correlation autophagy in oral squamous cell carcinoma (OSCC) pathogenesis remain unknown. In this study, effects on OSCC cells vitro were examined by proliferation assay, transwell chamber flow cytometry analysis and shRNA technique. Cellular key proteins to apoptosis evaluated Western blot immunofluorescent staining. Moreover, functions process observed nude mouse model. We...
To explore the expression of major histocompatibility complex classⅠchain-related protein A and B (MICA/B) in operable lung adenocarcinoma its clinical significance.Between January 2002 December 2003, 100 patients with People's Hospital Zhengzhou were collected. The MICA/B was examined by immunohistochemistry staining.According to immunohistochemical staining, cases score ≥5 points high while <5 low MICA/B.Chi-square test utilized analyze relationship between clinicopathologic features....