A5031934967- Tryptophan and brain disorders
- Gut microbiota and health
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and biological activity
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- Probiotics and Fermented Foods
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Synthesis and Characterization of Heterocyclic Compounds
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Click Chemistry and Applications
- Inflammasome and immune disorders
- Neuroendocrine regulation and behavior
- Treatment of Major Depression
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Barrier Structure and Function Studies
National Institute of Pharmaceutical Education and Research
2022-2025
National Institute of Pharmaceutical Education and Research
2020-2025
The University of Texas Health Science Center at Houston
2017-2022
Apollo Hospitals
2022
Lupin Pharmaceuticals (India)
2019-2020
Rashtrasant Tukadoji Maharaj Nagpur University
2005-2013
Iowa State University
1987
Depression is a debilitating mental disorder that affects >322 million people worldwide. Despite the availability of several antidepressant agents, many patients remain treatment refractory. A growing literature study has indicated role gut microbiota in neuropsychiatric disorders. Herein, we examined psychobiotic-like activity multi-strain probiotic formulation maternal separation (MS) and chronic unpredictable mild stress (CUMS) models anxiety- depression-like phenotypes Sprague-Dawley...
Alteration of gut microbiota and microbial metabolites such as short-chain fatty acids (SCFAs) coexisted with stress-generated brain disorders, including depression. Herein, we investigated the effect SCFAs in a treatment-resistant depression (TRD) model rat. Rats were exposed to chronic-unpredictable mild stress (CUMS) repeated adrenocorticotropic hormone (ACTH) injections generate TRD-like phenotype. The cecal contents these animals engrafted into healthy-recipient rats allowed colonize...
Abstract Introduction Probiotics made from Bacillus subtilis provide a wide spread of health benefits, particularly in the treatment diarrhea and gastrointestinal problems. Herein, we employed vitro vivo paradigms to assess potential adverse effects toxicity B. UBBS-14. Materials methods According Organization for Economic Co-operation Development (OECD) 423 407 requirements, preclinical investigation was conducted male female Sprague-Dawley rats. Acute examined following single peroral (PO)...
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12 p being most potent. It MCF-7 breast cells (IC
ABSTRACT Encorafenib is used to treat melanoma and colorectal tumors. Depression gastric ulcer conditions can impact various physiological processes, including drug metabolism pharmacokinetics. This study investigated the effect of a rat model depression ulcers on pharmacokinetics (PK) encorafenib using developed LC‐QqQ‐MS method. The chronic unpredictable mild stress (CUMS) indomethacin‐induced were utilized investigate orally administered encorafenib. focus was parameters such as maximum...
Stroke is a life-changing event as stroke survivors experience changes in personality, emotions and mood. We investigated the effect of xenon gas encapsulated liposomes on stroke-generated sensorimotor impairments, anxiety- depression-like phenotypes. Ischemic was created by intraluminal middle cerebral artery occlusion (MCAO) for 6 h followed reperfusion rats. Xenon-liposome (6 mg/kg, intravenous) treatment given multiple times starting at 2 post-ischemia through (5X), once-daily next 3...
Study aimed to design and development of a supramolecular formulation sulpiride (SUL) enhance its solubility, dissolution permeability by targeting novel GlyT1 inhibition mechanism. SUL is commonly used treat gastric duodenal ulcers, migraine, anti-emetic, anti-depressive anti-dyspeptic conditions. Additionally, Naringin (NARI) was incorporated as co-former the drug's intestinal P-glycoprotein (P-gp) efflux inhibition. NARI, flavonoid has diverse biological activities, including...