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G. Balakishan

ORCID: 0000-0002-8248-2159
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About
Contact & Profiles
A5103064778
Research Areas
  • Synthesis and pharmacology of benzodiazepine derivatives
  • Cancer therapeutics and mechanisms
  • Synthesis and Biological Evaluation
  • Carbohydrate Chemistry and Synthesis
  • Cancer Treatment and Pharmacology
  • Natural Antidiabetic Agents Studies
  • Synthesis and biological activity
  • Eicosanoids and Hypertension Pharmacology
  • Traditional and Medicinal Uses of Annonaceae
  • Synthesis and Reactivity of Heterocycles
  • Synthesis and Characterization of Heterocyclic Compounds
  • Phytochemistry and biological activities of Ficus species
  • Enzyme Production and Characterization
  • Phytochemistry and Bioactive Compounds
  • X-ray Diffraction in Crystallography
  • Food Science and Nutritional Studies
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Organic Chemistry Cycloaddition Reactions
  • Crystallization and Solubility Studies
  • Phytochemical Studies and Bioactivities
  • Synthesis and properties of polymers
  • HIV/AIDS drug development and treatment

Telangana University
 2016-2023

Kindai University
 2012-2016

Indian Institute of Chemical Technology
 2008-2010

 Synthesis and biological evaluation of 1-phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d]azepin-5(1H)-one/thiones as anticancer agents
OPENALEX - Publications 
Ramulu Parupalli Ravikumar Akunuri Akella Spandana Regur Phanindranath Suneela Pyreddy and 10 more Mohd Rabi Bazaz Manasa Vadakattu Swanand Vinayak Joshi Sushmitha Bujji G. Balakishan Venkata Madhavi Yaddanapudi Manoj P. Dandekar Velma Ganga Reddy Narayana Nagesh Srinivas Nanduri

10.1016/j.bioorg.2023.106478 article EN Bioorganic Chemistry 2023-03-17
 Synthesis and anti-cancer activity of chalcone linked imidazolones
OPENALEX - Publications 
Ähmed Kamal G. Ramakrishna P. V. K. Raju Viswanath Arutla M. Janaki Ramaiah and 2 more G. Balakishan Manika Pal‐Bhadra

10.1016/j.bmcl.2010.06.097 article EN Bioorganic & Medicinal Chemistry Letters 2010-06-26
 Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential
OPENALEX - Publications 
Ähmed Kamal Rajender D. Rajasekhar Reddy M. Kashi Reddy G. Balakishan and 3 more Thokhir Basha Shaik Mukesh Chourasia G. Narahari Sastry

10.1016/j.bmc.2008.12.068 article EN Bioorganic & Medicinal Chemistry 2009-01-07
 In silico design, synthesis and evaluation of 3′-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine “Salacia”
OPENALEX - Publications 
Genzoh Tanabe Shinya Nakamura Nozomi Tsutsui G. Balakishan Weijia Xie and 7 more Satoshi Tsuchiya Junji Akaki Toshio Morikawa Kiyofumi Ninomiya Isao Nakanishi Masayuki Yoshikawa Osamu Muraoka

With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a natural inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, have been developed.

10.1039/c2cc34144a article EN Chemical Communications 2012-01-01
 Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
OPENALEX - Publications 
Ähmed Kamal G. Balakishan G. Ramakrishna Thokhir Basha Shaik K. Sreekanth and 4 more Balakrishna Moku Rajender D. Dastagiri Shasi V. Kalivendi

10.1016/j.ejmech.2010.05.041 article EN European Journal of Medicinal Chemistry 2010-06-02
 Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole–pyrrolobenzodiazepine conjugates
OPENALEX - Publications 
Ähmed Kamal D. Dastagiri M. Janaki Ramaiah E. Vijaya Bharathi Jhansi Reddy and 7 more G. Balakishan P.N. Sarma S. N. C. V. L. Pushpavalli Manika Pal‐Bhadra Aarti Juvekar Subrata Sen Surekha M. Zingde

10.1016/j.bmc.2010.07.067 article EN Bioorganic & Medicinal Chemistry 2010-08-03
 Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines
OPENALEX - Publications 
Ähmed Kamal K. Sreekanth P. Praveen Kumar Nagula Shankaraiah G. Balakishan and 4 more M. Janaki Ramaiah S. N. C. V. L. Pushpavalli Paramita Ray Manika Pal Bhadra

10.1016/j.ejmech.2010.01.054 article EN European Journal of Medicinal Chemistry 2010-02-03
 Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine ‘Salacia’
OPENALEX - Publications 
Genzoh Tanabe Weijia Xie G. Balakishan Mumen F. A. Amer Nozomi Tsutsui and 7 more Haruka Takemura Shinya Nakamura Junji Akaki Kiyofumi Ninomiya Toshio Morikawa Isao Nakanishi Osamu Muraoka

10.1016/j.bmc.2016.06.013 article EN Bioorganic & Medicinal Chemistry 2016-06-07
 Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol
OPENALEX - Publications 
Genzoh Tanabe Youya Matsuda Misato Oka Yousuke Kunikata Nozomi Tsutsui and 5 more Weija Xie G. Balakishan Mumen F. A. Amer Shinsuke Marumoto Osamu Muraoka

A facile and highly diastereoselective route to potent natural α-glucosidase inhibitors, i.e., neosalacinol (4) neoponkoranol (6), isolated from the traditional Ayurvedic medicine "Salacia" was developed by intramolecular cyclization of appropriately substituted sulfides (9 12).

10.1021/acs.joc.5b02894 article EN The Journal of Organic Chemistry 2016-03-25
 An efficient total synthesis of vilanterol: an inhaled drug
OPENALEX - Publications 
Kamalaker Reddy Kamireddy Sailam Sri Gogula Venkateswarlu Banoji Sayaji Rao G. Balakishan

10.24820/ark.5550190.p011.957 article EN cc-by ARKIVOC 2023-08-01
 Synthesis, DNA-Binding Ability and Biological Activity of C8 Linked G1 Dendrimer-Pyrrolobenzodiazepine Conjugates as Anticancer Agents
OPENALEX - Publications 
Ahmed Kamal G. Balakishan Rajender K. Sreekanth D. Rajasekhar Reddy and 5 more M. Kashi Reddy Subrata Sen Nisha Kurian Aarti Juvekar Surekha M. Zingde

Some pyrrolo[2,1-c][1,4]benzodiazepine-G1 poly (aryl ether) dendrimer hybrids have been synthesized and evaluated for their DNA binding ability as well anticancer activity. The linkage of component significantly increased activity apart from the enhancement solubility, taking part a drug carrier. Keywords: G1 Poly dendrimer, Pyrrolobenzodiazepine, Piperazine, Lipophilicity, DNA-binding affinity cytotoxicity

10.2174/157018008785909859 article EN Letters in Drug Design & Discovery 2008-09-29
 ChemInform Abstract: Highly Diastereoselective Route to α‐Glucosidase Inhibitors, Neosalacinol (Ia) and Neoponkoranol (Ib).
OPENALEX - Publications 
Genzoh Tanabe Youya Matsuda Misato Oka Yousuke Kunikata Nozomi Tsutsui and 5 more Weija Xie G. Balakishan Mumen F. A. Amer Shinsuke Marumoto Osamu Muraoka

10.1002/chin.201634194 article EN ChemInform 2016-08-01
 P-7 Salacinolをシードとするスルホニウム塩型α-グルコシダーゼ阻害剤のin silico設計,合成及び評価(ポスター発表の部)
OPENALEX - Publications 
元三 田邉 真也 中村 正絋 吉長 望 筒井 G. Balakishan and 6 more 淳二 赤木 敏生 森川 清文 二宮 功 仲西 雅之 吉川 修 村岡

10.24496/tennenyuki.54.0_285 article JA 2012-09-01
 ChemInform Abstract: Synthesis and Potential Cytotoxic Activity of New Phenanthrylphenol‐Pyrrolobenzodiazepines.
OPENALEX - Publications 
Ahmed Kamal K. Sreekanth P. Praveen Kumar Nagula Shankaraiah G. Balakishan and 4 more M. Janaki Ramaiah S. N. C. V. L. Pushpavalli Paramita Ray Manika Pal Bhadra

Abstract The potential of title compounds (V) as anticancer agents is evaluated.

10.1002/chin.201041172 article EN ChemInform 2010-09-16
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