A5054146436- Gut microbiota and health
- Synthesis and biological activity
- Traumatic Brain Injury and Neurovascular Disturbances
- Synthesis and Characterization of Heterocyclic Compounds
- Epigenetics and DNA Methylation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Stress Responses and Cortisol
- Probiotics and Fermented Foods
- Bacillus and Francisella bacterial research
- RNA Interference and Gene Delivery
- Crystallography and molecular interactions
- Synthesis of Organic Compounds
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Berberine and alkaloids research
- Intensive Care Unit Cognitive Disorders
- Alkaloids: synthesis and pharmacology
- Circadian rhythm and melatonin
- Bioactive natural compounds
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Barrier Structure and Function Studies
- Pancreatic and Hepatic Oncology Research
- Tryptophan and brain disorders
- Acupuncture Treatment Research Studies
National Institute of Pharmaceutical Education and Research
2020-2025
National Institute of Pharmaceutical Education and Research
2024
University of Kashmir
2022
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12 p being most potent. It MCF-7 breast cells (IC
Study aimed to design and development of a supramolecular formulation sulpiride (SUL) enhance its solubility, dissolution permeability by targeting novel GlyT1 inhibition mechanism. SUL is commonly used treat gastric duodenal ulcers, migraine, anti-emetic, anti-depressive anti-dyspeptic conditions. Additionally, Naringin (NARI) was incorporated as co-former the drug's intestinal P-glycoprotein (P-gp) efflux inhibition. NARI, flavonoid has diverse biological activities, including...
Traumatic brain injury (TBI) is known as a silent epidemic that causes many deaths and disabilities worldwide. We examined the response of oxyberberine (OBB) in lipopolysaccharide-stimulated BV2 microglial cells controlled-cortical impact (CCI) mouse model TBI.We synthesized OBB from berberine, also prepared OBB-nanocrystals (OBB-NC). Male C57BL/6 mice were used for CCI surgery, post-CCI neurobehavioral deficits assessed 1 h after through 21 days post-injury (dpi).OBB treatment reduced...
Abstract Probiotics contain beneficial live bacteria that confer several health benefits to the host. For past 50 years, spore-forming Bacillus species have been used in form of probiotics. Among these, clausii strains are for management acute and antibiotic-associated diarrhoea. In present work, we evaluated asserted label information on randomly chosen commercial spore suspension probiotic products. The quality number viable were based colony count, antibiotic resistance, hemolytic...
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12p being most potent. It MCF-7 breast cells (IC50 value 3.14 ± 0.50 µM), evidenced by decrease in viable increased apoptotic features during phase contrast microscopy, AO/EB, DAPI DCFDA staining studies. Compound also inhibited cell migration colony...
In recent times, the incidence of polycystic ovary syndrome (PCOS) increases at an alarming rate.It is ascribed to metabolic and endocrine imbalance, which subsequently adversely impacts fertility women.Growing evidence indicates crucial role circadian biology in development progression PCOS.Here, we describe epigenetic machinery related genes (Clock, Bmal, Per, Cry) on insulin resistance hyperandrogenism components PCOS.We comprehensively discuss interconnection between genetics rhythm PCOS...