A5060769955- Synthesis and biological activity
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Synthesis of heterocyclic compounds
- Synthesis and bioactivity of alkaloids
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Angiogenesis and VEGF in Cancer
- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Catalytic Alkyne Reactions
- Synthesis of Organic Compounds
- Catalytic Cross-Coupling Reactions
- HER2/EGFR in Cancer Research
- Supramolecular Self-Assembly in Materials
- Microwave-Assisted Synthesis and Applications
- Tryptophan and brain disorders
- Biopolymer Synthesis and Applications
- PI3K/AKT/mTOR signaling in cancer
National Institute of Pharmaceutical Education and Research
2016-2025
University of Hyderabad
2020
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12 p being most potent. It MCF-7 breast cells (IC
Multi-reactive centered reagents are beneficial in chemical synthesis due to their advantage of minimal material utilization and formation less by-products. Trichloroisocyanuric acid (TCCA), a reagent with three reactive centers, was employed the spirooxindoles through oxidative rearrangement various N-protected tetrahydro-β-carbolines. In this protocol, low equivalents TCCA were required access (up 99% yield) wide substrate scope. Furthermore, applicability robustness protocol proven for...
Microwave-assisted dithiocarbamation of various imidazoheterocycles with in situ generated dithiocarbamates via a water-soluble Cu( i ) catalyst using benign solvent, enabling recyclability, scalability, less reaction time and high yields.
An efficient access to C3-functionalised 3-thiooxindoles has been accomplished via direct dithiocarbamation of spiro-aziridine oxindoles. Their apoptosis-inducing properties have investigated.
Abstract Tumor progression depends on angiogenesis, which is stimulated by growth factors like VEGF, targeting VEGFR kinase with small molecules an effective anti‐angiogenic therapeutic approach. The rational modification of sunitinib (VEGFR‐2 inhibitor) to spirocyclopropyloxindoline carboxamides have been performed and their in vitro cytotoxic profiling was evaluated. molecular modelling studies enabled the screening designed analogues identifying possible interactions within type III...
Abstract A facile one‐pot [3+2] cycloaddition reaction for the synthesis of diversely substituted spirooxindolo‐2‐iminothiazolidine scaffolds has been accomplished by employing FeCl 3 as catalyst. This proceeds via Lewis acid‐mediated activation spiro‐oxindole aziridines to generate a 1,3‐dipole which undergoes intramolecular with different aryl/alkyl isothiocyantes. The present method offers atom economy, broad substrate scope, good moderate yields, and wide functional group tolerance. In...
Abstract A series of new 5‐morpholino‐thiophene‐indole/oxindole hybrids has been designed and synthesized using molecular hybridization approach. The compounds were evaluated for their in vitro cytotoxic potential against selected human cancer cell lines such as triple negative breast (MDA‐MB‐231), liver (SK‐Hep‐1), (MCF‐7), colon (HCT‐116) mouse melanoma (B16F10) compared with normal lung epithelial line (BEAS‐2B). Among the tested 11a – o 13a d , compound 11f [( Z )‐ N ′‐((1‐Benzyl‐1 H...
Abstract A facile microwave‐assisted synthetic strategy for the construction of C–C bond via regioselective Friedel–Crafts arylation 3‐hydroxy‐3‐phenylethynyl oxindoles with different electron‐rich nucleophiles such as phenols, sulphonamides, anisole, benzofuran, and benzothiophene has been established by employing BF 3 ⋅ OEt 2 catalyst. The current protocol attributes mild conditions, cost‐effective, transition‐metal free synthesis, wide substrate scope moderate to good yields. Moreover,...
The synthesis of tetrahydro‐β‐carbolines (THβCs) framework is a fundamental aspect medicinal chemistry due to their significant pharmacological applications. Herein, we developed microwave‐assisted novel approach for the THβC scaffolds utilizing ferrous(II) chloride as an earth abundant metal catalyst and methanol used valuable methylene source. This methodology demonstrates excellent functional group tolerance provides N2‐substituted THβCs in good yields. Overall, this study highlights...
Abstract A facile synthesis of thioether‐linked 3‐hydroxy oxindoles was achieved through regiospecific ring‐opening spiroepoxy with oxadiazole‐2‐thiols and benzimidazole‐2‐thiols as nucleophiles. The thiol heteronucleophile attacks from the less hindered position spiroepoxides, yielding 3‐substituted‐3‐hydroxy in high yields (up to 86%). synthetic procedure offers an attractive route for diversely substituted that are prominent frameworks many natural products. Further, vitro cytotoxicity...
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12p being most potent. It MCF-7 breast cells (IC50 value 3.14 ± 0.50 µM), evidenced by decrease in viable increased apoptotic features during phase contrast microscopy, AO/EB, DAPI DCFDA staining studies. Compound also inhibited cell migration colony...
Abstract The catalyst of the scalable reaction procedure is recycled and reused in three additional catalytic cycles with slight loss its activity.
Abstract Brassinin, a phytochemical in cruciferous vegetables, is an indoleamine 2,3‐dioxygenase inhibitor and possesses therapeutic opportunity cancer immunotherapy. Here, we have developed validated novel, specific, rapid bioanalytical method rat plasma that unavailable the literature for preclinical studies. The development involved single‐step protein precipitation as extraction using acetonitrile with absolute relative mean recovery of 79.32% 93.59%, respectively. accurate precise over...