A5029223358- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Histone Deacetylase Inhibitors Research
- Wound Healing and Treatments
- Signaling Pathways in Disease
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Ion Channels and Receptors
- Cancer therapeutics and mechanisms
- Pharmacology and Obesity Treatment
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Medicinal Plants
- Kidney Stones and Urolithiasis Treatments
- HIV-related health complications and treatments
- Renal Diseases and Glomerulopathies
- NF-κB Signaling Pathways
- Dietary Effects on Health
- Drug Solubulity and Delivery Systems
- Natural Antidiabetic Agents Studies
- Luminescence and Fluorescent Materials
- Diverse Scientific Research Studies
- Kruppel-like factors research
Birla Institute of Technology and Science - Hyderabad Campus
2019-2025
Birla Institute of Technology and Science, Pilani
2020-2024
Vivekananda Global University
2020
Government Ayurved College, Nanded
2017
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12 p being most potent. It MCF-7 breast cells (IC
Abstract The advent of long-term implants has increased the urgent need for self-powered biomedical devices. Utilize enzymes to expedite process biofuel oxidation. These systems frequently make use glucose oxidase. A possible solution involves cells powered by found in physiological fluids. Biocompatible substances like carbon electrode designs help transport electrons from biological reactions external circuit as efficiently while maximizing surface area. Despite advances implantable...
N-hexylindole-linked anthracenyl twisted π-conjugates are identified as AIE-active DSEgens, which can inhibit FaDu and 4T1 cell lines but not HEK-293. The scathed fluorescence signals for make them recognizable over
A simple "click" protocol was employed in the quest of synthesizing 1,2,3-triazole-linked benzimidazoles as promising anticancer agents on various human cancer cell lines such A549, HCT116, SK-Mel-28, HT-29, and MCF-7. Compound 12j demonstrated significant cytotoxic potential towards SK-Mel-28 cells (IC50 : 4.17 ± 0.09 µM) displayed no cytotoxicity > 100 against normal BEAS-2B inferring its safety healthy cells. Further to comprehend underlying apoptosis mechanisms, AO/EB,...
Obesity and hyper-intestinal permeability are interconnected. This study is designed to evaluate the ability of Mangifera indica seed kernel extract (MESK) in restoring intestinal barrier preventing obesity associated metabolic complications a high-fat diet-induced obese mouse model. Four groups Swiss albino mice: (1) normal diet (ND), (2) (HFD), (3) HFD + Orlistat (100 µg/kg), (4) MESK (75 were used monitor various biochemical parameters with syndrome (glucose, total cholesterol,...
Zinc homeostasis, which allows optimal zinc utilization in diverse life processes, is responsible for the general well-being of human beings. This paper describes developing and validating an easily accessible indole-containing zinc-specific probe cellular milieu. The was synthesized from readily available starting materials subjected to steady-state fluorescence studies. It showed selective sensing behavior towards Zn
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most the molecules exhibited significant antiproliferative activity compound 12p being most potent. It MCF-7 breast cells (IC50 value 3.14 ± 0.50 µM), evidenced by decrease in viable increased apoptotic features during phase contrast microscopy, AO/EB, DAPI DCFDA staining studies. Compound also inhibited cell migration colony...
An operationally simple 'click' protocol was employed in quest of synthesising 1,2,3-triazolo-2-aryl-linked benzimidazole derivatives as promising anti-cancer agents. These new were tested for their potential on various human cancer cell lines (A549, HCT116, SK-Mel-28, HT-29 and MCF-7). On vitro evaluation the 11a-t 12a-m, compound 12j demonstrated significant cytotoxic towards SK-Mel-28 cells (IC50: 4.17 ± 0.09 µM). The most >100 µM) displayed no cytotoxicity against normal BEAS-2B...
A new class of benzimidazole derivatives as tubulin polymerization inhibitors has been designed and synthesized in this study. The vitro anticancer profile the developed molecules was reconnoitred on selected human cancer cells. highest cytotoxicity illustrated by compounds 7n 7u with IC50 values ranging from 2.55–17.89 µM specificity toward SK-Mel-28 They displayed 5-fold less towards normal rat kidney epithelial NRK52E cells, which implies that they are not harmful to normal, healthy...