A5040469336- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Toxin Mechanisms and Immunotoxins
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Drug Solubulity and Delivery Systems
- Luminescence and Fluorescent Materials
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- X-ray Diffraction in Crystallography
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Surgical Sutures and Adhesives
- Silk-based biomaterials and applications
- Hydrogels: synthesis, properties, applications
- Advanced Nanomaterials in Catalysis
- Monoclonal and Polyclonal Antibodies Research
Birla Institute of Technology and Science - Hyderabad Campus
2016-2025
Birla Institute of Technology and Science, Pilani
2011-2024
Government of India
2022
Medical Research Council
2022
Indian Council of Medical Research
2022
L V Prasad Eye Institute
2022
GTx (United States)
2017
South Dakota State University
2008-2014
Brookings Institution
2014
Skin cancer is one of the most widely prevalent types with over expression multiple oncogenic signaling molecules including STAT3. Curcumin a natural compound effective anti-cancer properties. The objective this work was to investigate liposomal co-delivery curcumin and STAT3 siRNA by non-invasive topical iontophoretic application treat skin cancer. encapsulated in cationic liposomes then complexed siRNA. nanocomplex characterized for particle size, zeta-potential, drug release stability....
The aim of this study was to investigate the feasibility using layer-by-layer polymer coated gold nanoparticles (AuNP) as a carrier for topical iontophoretic delivery imatinib mesylate (IM). AuNP were prepared by Turkevich method and stabilized functionalized polyvinylpyrrolidone polyethylene imine. then sequentially with anionic poly(styrenesulfonate) cationic imine loaded IM. (LbL-AuNP) showed average particle size zeta-potential 98.5 ± 4.3 nm 32.3 1.3 mV respectively. After LbL coating...
Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy anticancer agents. The aim this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes treat breast cancer. Liposomes were prepared 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), monopalmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC), different surface active characterized the average particle size, zeta potential, transition...
The study was aimed at investigating the feasibility of using a poly (amidoamine) (PAMAM) dendrimer as carrier for topical iontophoretic delivery an antisense oligonucleotide (ASO). Bcl-2, anti-apoptotic protein implicated in skin cancer, used model target to demonstrate gene silencing approach. Confocal laser scanning microscopy studies demonstrated that iontophoretically delivered ASO-dendrimer complex can reach viable epidermis porcine skin. In contrast, passively free or complexed ASO...
Context: Enhacing the ocular bioavailability of drugs after their topical application is a challenge.Objective: The objective study was to design, fabricate, and investigate effectiveness microneedle patch (MOP) in delivering model drug, pilocarpine HCl across corneal membrane.Methods: MOP mimicked commercially available contact lens design elements having diameter 14.20 mm sagittal height 3.85 with convex curvature. base this contained an array 25 pyramid-shaped microneedles measuring 521 ±...
The aim of the study was to develop and evaluate efficacy a functionalized layer-by-layer (LbL) assembled film entrapped with oxaliplatin (OX) signal transducer activator transcription 3 (STAT3) siRNA in localized treatment colon cancer. LbL prepared by sequential layering chitosan (CS) alginate attain desired physical mechanical properties. coating folic acid-conjugated CS on one side. On other side, polycaprolactone coated as backing layer provide directional drug release. OX within layers...
Transcutaneous antigen administration provides an alternative to invasive syringe injections. The objective of this study was investigate the feasibility fabrication and delivery using microneedles made from corn protein, zein. Micromolding technique used cast cone-shaped zein (ZMNs). insertion ZMNs model antigen, ovalbumin (OVA), into skin confirmed by histological examination confocal microscopy. In addition, a significantly (p < 0.05) lower bacterial penetration observed after ZMN...