Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD1 mice were used. Both had initiated with an initial topical exposure 7,12-dimethylbenzanthracene and biweekly promotion using 12-O-tetradecanoylphorbol 13-acetate (TPA). The experimental group pretreated 5% pomegranate prior to TPA application. Tumor incidence, number containing at least one tumor, 100% 93%,...

Abstract Abstract: Fatty acid composition of dietary fat plays a vital role in colon tumor development animal models. Fats containing ω-6 fatty acids (e.g., corn oil) enhanced and ω-3 flaxseed reduced chemically induced rats. Lignans have also been shown to prevent experimental animals. The objective this investigation is study the effects meal, source both lignans, on compare them with meal. Male Fischer rats, two groups 24 each, were assigned AIN-93M diet supplemented either 15% meal or...

Ghee, also known as clarified butter, has been utilized for thousands of years in Ayurveda a therapeutic agent. In ancient India, ghee was the preferred cooking oil. last several decades, implicated increased prevalence coronary artery disease (CAD) Asian Indians due to its content saturated fatty acids and cholesterol and, heated ghee, oxidation products. Our previous research on Sprague-Dawley outbred rats, which serve model general population, showed no effect 5 10% ghee-supplemented...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted thiazolidones as anticonvulsantsC. Dwivedi, T. K. Gupta, and Surendra S. ParmarCite this: J. Med. Chem. 1972, 15, 5, 553–554Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 1972https://doi.org/10.1021/jm00275a031RIGHTS & PERMISSIONSArticle Views115Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November...

The study was aimed at investigating the feasibility of using a poly (amidoamine) (PAMAM) dendrimer as carrier for topical iontophoretic delivery an antisense oligonucleotide (ASO). Bcl-2, anti-apoptotic protein implicated in skin cancer, used model target to demonstrate gene silencing approach. Confocal laser scanning microscopy studies demonstrated that iontophoretically delivered ASO-dendrimer complex can reach viable epidermis porcine skin. In contrast, passively free or complexed ASO...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted thiazolidones and their selective inhibition of nicotinamide-adenine dinucleotide dependent oxidationsSurendra S. Parmar, C. Dwivedi, A. Chaudhari, T. K. GuptaCite this: J. Med. Chem. 1972, 15, 1, 99–101Publication Date (Print):January 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://doi.org/10.1021/jm00271a030RIGHTS & PERMISSIONSArticle Views105Altmetric-Citations41LEARN ABOUT THESE...

Fatty acid composition of dietary fat, primarily the levels omega-3 and omega-6 polyunsaturated fatty acids, has shown profound effect on colon tumor development in animal studies. Fats containing acids (for example, corn oil) enhanced fish oil mustard reduced chemically induced tumors rats. The purpose this study was to investigate effects flaxseed (containing alpha-linolenic acid, an acid) azoxymethane-induced rats how it compared with oil-treated group. Male Fischer rats, separated into 2...

Dietary flaxseed has been shown to prevent azoxymethane (AOM)-induced colorectal cancers in male Fisher rats. The present study was designed investigate the chemopreventive effects of dietary on development intestinal tumors Apc Min mice. mice were divided into five different groups, fed with control (AIN-93M meal), corn meal, oil, and oil supplemented diets. Results showed that significantly decreased ( P < 0.05) tumor multiplicity size small intestine colon as compared control,...

Magnolol, a plant lignan isolated from the bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on chemically-induced skin cancer development. The objectives this investigation are study anticarcinogenic magnolol UVB-induced tumor development in SKH-1 mice, model relevant humans, determine possible role apoptosis cell cycle arrest involved development.UVB-induced carcinogenesis mice was used for determining preventive Western blottings flow cytometric...

alpha-Santalol, an active component of sandalwood oil, has shown chemopreventive effects on skin cancer in different murine models. However, alpha-santalol cell cycle have not been studied. Thus, the objective this study was to investigate progression both p53 mutated human epidermoid carcinoma A431 cells and wild-type melanoma UACC-62 elucidate mechanism(s) action. MTT assay used determine viability UACC-62; fluorescence-activated sorting (FACS) analysis propidium iodide staining for...

The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment inflammatory and eruptive skin diseases. In this investigation, chemopreventive effects oil (5% acetone, w/v) on 7,12-dimethylbenz(a)anthracene- (DMBA)-initiated 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted papillomas, TPA-induced ornithine decarboxylase(ODC) activity CD, mice were studied. Sandalwood significantly decreased papilloma incidence...

Recent studies from our laboratory have shown the chemopreventive effects of α-santalol against 7,12-dimethylbenzanthracene (DMBA) initiated and 12- O -tetradecanoylphorbol-13-acetate (TPA) promoted skin tumor development in mice. The objective present investigation was to study on ultraviolet B (UVB) radiation-induced UVB-caused increase epidermal ornithine decarboxylase (ODC) activity female hairless SKH-1 For studies, 180 mice were divided into three groups 60 each, each group two...

Anticancer efficacy and the mechanism of action α-santalol, a terpenoid isolated from sandalwood oil, were investigated in human breast cancer cells by using p53 wild-type MCF-7 as model for estrogen receptor (ER)-positive mutated MDA-MB-231 ER-negative cancer. α-Santalol inhibited cell viability proliferation concentration time-dependent manner both regardless their ER and/or status. However, α-santalol produced relatively less toxic effect on normal epithelial line, MCF-10A. It induced...

Journal Article Effects of Verapamil on the Acute Toxicity Doxorubicin In Vivo Get access Rajagopalan Sridhar, Sridhar Department Radiation Therapy and Cancer Center, Howard University HospitalWashington, D.C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Chandradhar Dwivedi, Dwivedi College Pharmacy, South Dakota State UniversityBrookings Jayna Anderson, Anderson Peter B. Baker, Baker Medicine, The Ohio UniversityColumbus Hari M. Sharma, Sharma Pankaj...

Honokiol is a plant lignan isolated from bark and seed cones of Magnolia officinalis. Recent studies our laboratory indicated that honokiol pretreatment decreased ultraviolet B-induced skin cancer development in SKH-1 mice. The aim the present investigation was to study effects on human epidermoid squamous carcinoma A431 cells elucidate possible mechanisms involved preventing cancer. were pretreated with different concentrations for specific time period investigated apoptosis cell cycle...

Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth vitro by inducing apoptosis, but the mechanisms underlying inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway migration cultured cells. Materials and Methods: Migration assays, immunoblotting immunofluorescence were used examine mechanism action a-santalol Results: Exposure...