A5042939761- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Synthesis and bioactivity of alkaloids
- Advanced biosensing and bioanalysis techniques
- Synthesis and biological activity
- DNA and Nucleic Acid Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallography and molecular interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of Organic Compounds
- Organometallic Complex Synthesis and Catalysis
- Enzyme function and inhibition
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Production and Characterization
- Genomics and Phylogenetic Studies
- Molecular Sensors and Ion Detection
- Metabolomics and Mass Spectrometry Studies
- Synthesis and Reactivity of Heterocycles
- Mitochondrial Function and Pathology
- Multicomponent Synthesis of Heterocycles
Centre for Cellular and Molecular Biology
2015-2024
Academy of Scientific and Innovative Research
2022-2024
Directorate of Medicinal and Aromatic Plants Research
2020
University of Hyderabad
2014-2017
Manipal Hospital
2016
Indian Institute of Chemical Technology
2013-2014
Nizam's Institute of Medical Sciences
2014
University of Neuchâtel
2014
James Cook University
2014
Aims: The aim of the study was to optimize microbial degradation keratinous waste and characterize alkaline active keratinase showing its biotechnological importance. Method Results: An extracellular enzyme purified from culture medium a bacterial isolate conditions were optimized. molecular weight DEAE-Sepharose-purified determined by SDS-PAGE. Instrumental analyses investigated mechanism bovine hair hydrolysis. Isolate identified as Bacillus pumilus based on phenotypic characteristics 16S...
Abstract A series of β‐carboline hybrids bearing a substituted phenyl and chalcone/( N‐ acetyl)‐pyrazole moiety at the C1 C3 positions, respectively, was designed, synthesized, evaluated for anticancer activity. These new hybrid molecules showed significant cytotoxic activity, with IC 50 values ranging from <2.0 μ M to 80 , structure–activity relationships (SAR) associated substitutions positions 1 3 these clearly addressed. Further, induction apoptosis confirmed by Annexin V‐FITC,...
Abstract Copper oxide nanoparticles that are supported on graphene as a catalytic system have been utilized for ligand‐free and solvent‐free CS cross‐coupling reactions with weak bases such triethylamine. Symmetrical/unsymmetrical aryl sulfides synthesized by the coupling of different halides aromatic well aliphatic sulfides. Surprisingly, chlorides also reacted types in presence dimethyl sulfoxide cesium carbonate. Besides, this is suitable synthesis phenothiazines via cascade CN ortho...
Hypnea musciformis red seaweed is popularly known to produce carrageenan was collected from the Gulf of Mannar, India. Strain HMGM-7 [MTCC 11712] isolated surface this seaweed, which capable producing an extracellular black-coloured polymeric pigment. Based on phenotypic characterization and 16S rDNA sequencing, strain identified as Pseudomonas stutzeri. Biophysical by UV–visible, FT-IR, EPR XRD spectroscopic studies confirmed pigment melanin. Further chemical showed that it acid-resistant,...
A series of β-carboline–benzimidazole conjugates were synthesized using lanthanum nitrate as a novel catalyst and evaluated for their anticancer activity.
The interactions of three related cationic porphyrins, TMPyP4, TMPyP3 and TMPyP2, with a WT 39-mer Bcl-2 promoter sequence G-quadruplex were studied using Circular Dichroism, ESI mass spectrometry, Isothermal Titration Calorimetry, Fluorescence spectroscopy. planar porphyrin TMPyP4 (5, 10, 15, 20-meso-tetra (N-methyl-4-pyridyl) porphine) is shown to bind via two different binding modes, an end mode weaker attributed intercalation. non-planar ligands, are the by single mode. spectrometry...
A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their <italic>in vitro</italic> cytotoxicity on selected human cancer cell lines.
ABSTRACT Xanthomonadins are membrane-bound, brominated, aryl-polyene pigments specific to the genus Xanthomonas . We have characterized a genetic locus ( pig ) from oryzae pv. which contains four open reading frames (ORFs) that essential for xanthomonadin production. Three of these ORFs homologous acyl carrier proteins, dehydratases, and transferases, suggesting type II polyketide synthase pathway biosynthesis. The fourth ORF has no homologue in database. For first time, we report putative...