A5046059346- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- Cancer therapeutics and mechanisms
- Allelopathy and phytotoxic interactions
- Quinazolinone synthesis and applications
- Chemical synthesis and alkaloids
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antimicrobial Resistance in Staphylococcus
- Insect Pest Control Strategies
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Bioactive Compounds and Antitumor Agents
- Tuberculosis Research and Epidemiology
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Nematode management and characterization studies
- Medicinal Plants and Neuroprotection
- Antibiotic Use and Resistance
- Synthesis of heterocyclic compounds
Central Drug Research Institute
2019-2025
Academy of Scientific and Innovative Research
2022
Council of Scientific and Industrial Research
2022
Indian Agricultural Research Institute
1976-2007
Panjab University
1991
Institute of Minerals and Materials Technology
1982-1983
Indian Institute of Integrative Medicine
1982
Advanced Materials and Processes Research Institute
1982
The emergence of antibiotic resistance to
The drastic increase in the emergence of methicillin and vancomycin resistant S. aureus has resulted almost negligible treatment options available to tackle these drug‐resistant strains therefore, search for newer antibiotics is essential. In this context, a new series quaternized fused β‐carbolines was synthesized evaluated its anti‐bacterial potential. Several compounds from displayed potent activity against Gram‐positive bacteria including with minimal cytotoxicity promising bactericidal action.
Lipopeptide-inspired, short peptide amphiphile-meropenem nanostructures enhance antibiotic efficacy, increase local concentration, reduce dosages, and minimize cytotoxicity, enabling efficient delivery to combat drug-resistant infections.
Strategically controlling concentrations of lipid-conjugated L-tryptophan (vsPA) guides the self-assembly nanostructures, transitioning from nanorods to fibres and culminating in spherical shapes. The resulting Peptide-Au hybrids, exhibiting size-controlled 1D, 2D, 3D show potential antibacterial applications. Their high biocompatibility, favourable surface area-to-volume ratio, plasmonic properties contribute their effectiveness against clinically relevant bacteria. This controlled approach...
Abstract A series of pyrrole‐thiazolidin‐4‐one conjugates were synthesized and evaluated for their anti‐mycobacterial anti‐bacterial activities. Two compounds, 10 a k , the most effective produced identical MICs (0.5 μg/mL) against M. tuberculosis H37Rv with high selectivity index. Upon evaluation ESKAP bacteria panel, compound g emerged S. aureus (MIC=8.0 while o activity A. baumannii (MIC=4.0 μg/mL). molecular docking study revealed that active has similar binding interactions as those...
The synthesis of sixteen tryptanthrin appended dispiropyrrolidine oxindoles, employing [3 + 2] cycloaddition tryptanthrin-derived azomethine ylides with isatilidenes, and their detailed antibacterial evaluation is described.
Novel PEGylated copper pyrithione complexes show high bioactivity in anticancer and antibacterial assays, with enhanced aqueous solubility.
Abstract The syntheses of some 2‐mercaptobenzimidazole (I) derivatives have been described. While preparing such compounds it has observed that I reacts predominantly as the thione under anhydrous reaction conditions, and thiol in presence an alkali. Strutures all nine established with help spectral methods including 13 C nmr spectroscopy two (II III).
An amyloid-β inspired biocompatible short peptide amphiphile (sPA) molecule was used for controlled and targeted delivery of bioactive silver nanoparticles via transforming sPA nanostructures. Such sPA-AgNPs hybrid structures can be further to develop antibacterial materials combat emerging bacterial resistance. Due the excellent activity silver, growth clinically relevant bacteria inhibited in presence AgNPs-sPA hybrids. Bacterial tests demonstrated that high biocompatibility low...
In the pursuit to combat stubborn bacterial infections, particularly those stemming from gram-positive bacteria, this study is an attempt craft a precision-driven platform characterized by unparalleled selectivity, specificity, and synergistic antimicrobial mechanisms. Leveraging remarkable potential of metalloantibiotics in applications, herein, work rationally designs, synthesizes, characterizes new library Pyridine-2,6-dicarboxamide ligands their corresponding transition metal...
To date, the use of corannulene has been restricted in area material science, but its application biomedical research yet to be established due nonsolubility an aqueous environment and synthetic infeasibility. Herein, we detail development a new family highly curved π-conjugated corannulene-containing unnatural α-amino acid (CAA) derivatives overcome this challenge. These CAAs have extended as novel constituents for synthesis water-soluble cationic peptides (CCPs), which display inhibitory...
Abstract This communication describes synthesis and spectral data of new 2‐mercaptobenzimidazole derivatives.
Antimicrobial resistance is a serious challenge to modern medicine. Besides imposing high financial burden, multidrug resistant infections are directly responsible for morbidity and mortality. Even though number of antibiotics currently available treat caused by ESKAPE organisms, more bacterial strains becoming these drugs. Prevailing circumstances pose an urgent unmet need the development newer antimicrobials MDR organisms. Rhodanine structurally related 5-membered heterocycles possess wide...
Abstract The microbiota‐gut‐brain axis (GBA) plays a critical role in the development of neurodegenerative diseases. Dysbiosis intestinal microbiome causes significant alteration gut microbiota Alzheimer's disease (AD) patients, followed by neuroinflammatory processes. Thus, AD beginning is closely related to an imbalance microbiota, and hence multidomain approach reduce this exerting positive effects on needed. In one example, tyrosine‐based short peptide amphiphile (sPA) was used...
Abstract Antimicrobial resistance is a serious public health risk. Its severity fueled on an unprecedented scale, necessitating the demand for novel antimicrobial scaffolds aimed at targets. Herein, we present cationic chlorpromazine peptide conjugates that are rationally intended to targetmultidrug‐resistant (MDR) bacteria. The most potent compound, CPWL , of all evaluated, showed promising antibacterial activity against clinical, MDR S. aureus with no cytotoxicity. molecular docking...