A5047918573- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
- Synthesis and Catalytic Reactions
- Enzyme function and inhibition
- Galectins and Cancer Biology
- Click Chemistry and Applications
- Antibiotic Resistance in Bacteria
- Chemical Reactions and Mechanisms
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
- Innovative Microfluidic and Catalytic Techniques Innovation
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Chemical synthesis and alkaloids
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Crystallization and Solubility Studies
- Microwave-Assisted Synthesis and Applications
- Signaling Pathways in Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Multicomponent Synthesis of Heterocycles
National Institute of Pharmaceutical Education and Research
2019-2025
University of Kansas
2025
National Institute of Pharmaceutical Education and Research
2022-2024
Government of India
2021
Abstract A series of novel morpholines linked coumarin–triazole hybrids ( 6a–6v ) has been synthesized and evaluated for their anti‐proliferative potential on a panel five human cancer cell lines, namely bone MG ‐63), lung (A549), breast MDA ‐ MB ‐231), colon HCT ‐15) liver (HepG2), using MTT assay. Among all, the compound 6n {7‐((1‐(2,4‐dichlorobenzyl)‐1H‐1,2,3‐triazol‐4‐yl) methoxy)‐4‐((2,6‐dimethylmorpholino) methyl)‐2H‐chromen‐2‐one} showed significant growth inhibition against ‐63 cells...
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular extracellular pH hypoxic tumours abetting metastasis of solid tumours. Selective potent inhibitors targeting carbonic reduce activity these tumours, representing an antitumor antimetastatic mechanism. Coumarin-based derivatives are selective CA XII. In this study, we report design synthesis new 3-substituted coumarin with different functional moieties their inhibitory against various isoforms....
The emergence of antibiotic resistance to
8-Hydroxyquinoline and 4-thiazolidinone derivatives are promising antimicrobial agents, recognized for their activity against resistant pathogens. The aim of this study is to develop 8-hydroxyquinoline-4-thiazolidinone as potential agents. Using a one-pot reaction with sodium tetrafluoroborate an efficient eco-friendly catalyst, compounds 6a - l were synthesized subsequently screened antibacterial antifungal activity. Additionally, molecular docking dynamic simulations performed evaluate the...
Human Galectin-1, a protein of lectin family showing affinity towards β-galactosides has emerged as critical regulator tumor progression and metastasis, by modulating diverse biological events including homotypic cell aggregation, migration, apoptosis, angiogenesis immune escape. Therefore, galectin-1 inhibitors might represent novel therapeutic agents for cancer.A new series heterocyclic imines linked coumarin-thiazole hybrids (6a-6r) was synthesized evaluated its cytotoxic potential...
Abstract Carbonic anhydrase isoforms IX and XII are overexpressed in hypoxic tumor cells regulating various physiological processes such as cell proliferation, invasion, metastasis, resulting the onset spread of cancer. Selective inhibition these enzymes is a promising strategy for anticancer therapy. Coumarin derivatives were identified selective potent inhibitors isoforms. This study reports 6‐aminocoumarin sulfonamide oxime ether linked through chloroacetyl moiety tethered to piperazine...
Abstract Rhodanine and its derivatives are an important class of heterocycles with diverse biological properties, including anticancer, antibacterial, anti‐mycobacterial activities. In the present work, four series new were synthesized evaluated for their inhibitory activity against carbonic anhydrase I, II, IX, XII isoforms. Interestingly, tested compounds exhibited good cytosolic isoform human (hCA) II tumor‐associated hCA IX. While Rhodanine‐benzylidene ( 3a–l ) Rhodanine‐hydrazine 6a–e...
One-pot tandem synthesis of diverse pyrido[2′,1′:2,3]imidazo[4,5- c ]quinolines as new antimycobacterial agents through a Cu( i )-catalyzed microwave-assisted protocol.
Abstract The increase in the prevalence of multi‐drug‐resistant bacteria poses a significant healthcare challenge. urgent need to combat resistant microbes necessitates discovering new antibacterial agents capable circumventing existing resistance mechanisms. Targeting DNA gyrase by suitably modifying fluoroquinolones can lead antibiotics with better activity and lower incidence resistance. substituted diphenyl ethers like triclosan are known have potent activity. In current study,...
Thromboembolic disorders affect millions of people worldwide. Anticoagulant drugs, such as Dabigatran etexilate, Rivaroxaban, Argatroban, Enoxaparin, and Fondaparinux, are commonly used in treating most these diseases. etexilate (PRADAXA), the first oral direct thrombin inhibitor its kind, has become a leading anticoagulant therapy for various thromboembolic disorders. Numerous efforts have been made to synthesize API intermediates. This review comprehensively examines diverse methodologies...
A novel protocol is developed towards the preparation of alkylated ketones from alcohols in presence catalytic amount SmI2 and base with elimination water as a single by-product under microwave irradiation conditions. Furthermore, applicability this methodology to synthesis Donepezil late-stage functionalization Pregnenolone also reported. Successful application Friedländer quinolone using 2-aminobenzyl alcohol various acetophenones expand synthetic utility protocol.
Amid the mounting burden of multidrug-resistant (MDR) bacterial infections on health care worldwide, drug repurposing, a time and cost-effective strategy to identify new applications for drugs approved other indications, can effectively fill void in current antibiotic pipeline. In this study, we have repurposed topical antifungal agent, oxiconazole, combination with gentamicin against skin caused by Staphylococcus aureus. Oxiconazole was identified as having antibacterial activity S. aureus...
Abstract Severity of Infections caused by Staphylococcus aureus ranges from trivial to spine chilling. Irrespective multiple drugs availability treat S. infections, increase in drug‐resistance has led the continuous emergence resistant strains all including MRSA. Hence, there is an urgent unmet need for novel antibacterial agents combat multi drug infections which act through unexploited targets/mechanism. Bacterial pyruvate kinase (PK) one such unique cytoplasmic enzyme crucial carbohydrate...
Fluorine-18 is one of the promising radiotracers that can report target specific information related to its physiology understand disease status through PET modality. In current study, radiochemical synthesis, purification, and molecular docking studies fluorine-18 (18F) radiolabeled coumarin-triazole hybrid have been performed.To develop radiotracer for diagnosis in oncology.GE Tracer-lab FX2N module with few modifications line connections was used radiosynthesis purification molecule...
Abstract A novel, base‐ and ligand‐free one pot protocol for the synthesis of fused‐quinazolinone under microwave irradiation using environmentally friendly PEG‐400 as a solvent has been developed. Besides benzaldehyde, various benzyl alcohols methyl arenes were used in this protocol, which extend its synthetic applicability. Photophysical study highly fluorescent framework was studied by study. DFT ESI/MS studies carried out to justify proposed mechanism.