Several Ru-arene and Ir–Cp* complexes have been prepared incorporating (N,N), (N,O) (O,O) coordinating bidentate ligands found to be active against both HT-29 MCF-7 cell lines. By a biologically ligand into metal complex the anti-cancer activity is increased.

Enantiomers of a relatively rigid DNA-binding metallo-helix are shown to have comparable activity that cisplatin against the cell lines MCF7 (human breast adenocarcinoma) and A2780 ovarian carcinoma) but ca five times more active cisplatin-resistant A2780cis. The cell-line HCT116 p53+/+ colon is highly sensitive giving IC50 values in nM range, far lower than control. hypothesis biological target such metallohelices DNA probed by various techniques. Tertiary structure changes ct-DNA...

A series of ruthenium and iridium complexes have been synthesized characterized with 20 novel crystal structures discussed. The library β-ketoiminato has shown to be active against MCF-7 (human breast carcinoma), HT-29 colon A2780 ovarian A2780cis (cisplatin-resistant human carcinoma) cell lines, selected complexes' being more than three times as cisplatin the line. Selected were also tested noncancerous ARPE-19 (retinal pigment epithelial cells) line, in order evaluate selectivity for...

Uranyl complexes of a large, compartmental N8-macrocycle adopt rigid, "Pacman" geometry that stabilizes the UV oxidation state and promotes chemistry at single uranyl oxo-group. We present here new straightforward routes to singly reduced oxo-silylated Pacman propose mechanisms account for product formation, byproduct distributions are formed using alternative reagents. Uranyl(VI) in which one oxo-group is functionalized by metal cation activated toward single-electron reduction. As such,...

The synthesis and characterization of 24 ruthenium(II) arene complexes the type [(p-cym)RuCl(Fc-acac)] (where p-cym = p-cymene Fc-acac functionalized ferrocenyl β-diketonate ligands) are reported, including single-crystal X-ray diffraction for 21 new complexes. Chemosensitivity studies have been conducted against human pancreatic carcinoma (MIA PaCa-2), colorectal adenocarcinoma p53-wildtype (HCT116 p53+/+) normal retinal epithelial cell lines (APRE-19). most active complex, which contains a...

Uranyl Pacman takes them all: the bonding of s- and d-block cations to uranyl is compared by experiment, spectroscopy theory.

Reporting potent anticancer activity of new functionalised Group 9 dimers.

The first use of a dinuclear UIII/UIII complex in the activation small molecules is reported. octadentate Schiff-base pyrrole, anthracene-hinged 'Pacman' ligand LA combines two strongly reducing UIII centres and three borohydride ligands [M(THF)4][{U(BH4)}2(μ-BH4)(LA)(THF)2] 1-M, (M = Li, Na, K). bound to uranium outside macrocyclic cleft are readily substituted by aryloxide ligands, resulting single, weakly-bound, encapsulated endo group 1 metal bridging [{U(OAr)}2(μ-MBH4)(LA)(THF)2] 2-M...

In the past decade, libraries of iridium organometallic arene compounds have expanded rapidly, with majority their applications aimed towards effective catalysts and potential anti-cancer dr...

Abstract Group IV metal complexes have previously shown promise as novel anticancer agents. Here, we discuss the mechanistic and cytotoxic nature of a series group β‐diketonate coordination complexes. Clear evidence that ligands are exchangeable on centre can act potential drug delivery vehicles ions was obtained. When evaluated for cytotoxicity against human colon adenocarcinoma (HT‐29) breast (MCF‐7) cell lines, general trend decreasing potency down metals observed. The most promising...

Novel PEGylated copper pyrithione complexes show high bioactivity in anticancer and antibacterial assays, with enhanced aqueous solubility.

This work presents the synthesis of five new functionalized (benz)imidazolium

Abstract A library of new bis‐picolinamide ruthenium(III) dihalide complexes the type [RuX 2 L ] (X=Cl or I, L=picolinamide) have been synthesised and characterised. The exhibit different picolinamide ligand binding modes, whereby one is bound (N,N) other (N,O). Structural studies revealed a mixture cis trans isomers for [RuCl but upon halide exchange reaction to yield [RuI ], only single were detected. High cytotoxic activity against human cancer cell lines was observed, with potencies some...

Abstract The synthesis and characterization of new bis(bipyridine)ruthenium(II) ferrocenyl β‐diketonate complexes, [(bpy) 2 Ru(Fc‐acac)][PF 6 ] (bpy=2,2′‐bipyridine; Fc‐acac=functionalized ligand) are reported. Alongside clinical platinum drugs, these bimetallic ruthenium‐iron complexes have been screened for their cytotoxicity against MIA PaCa‐2 (human pancreatic carcinoma), HCT116 p53 +/+ colon carcinoma, ‐wild type) ARPE‐19 retinal pigment epithelial) cell lines. With the exception one...

A bacteria binding polymer, HB-PNIPAM-van, reduces bioburden of <italic>Staphylococcus aureus</italic> in a model corneal infection.

A series of cyclometallated mono- and di-nuclear platinum(II) complexes the parent organic ligand, 2,6-diphenylpyridine 1 (HC^N^CH), have been synthesized characterized. This library compounds includes [(C^N^C)Pt

Abstract Antimicrobial resistance genes (ARG), such as extended-spectrum β-lactamase (ESBL) and carbapenemase genes, are commonly carried on plasmids. Plasmids can transmit between bacteria, disseminate globally, cause clinically important resistance. Therefore, targeting plasmids could reduce ARG prevalence, restore the efficacy of existing antibiotics. Cobalt complexes possess diverse biological activities, including antimicrobial anticancer properties. However, their effect plasmid...

This work presents the unusual reactivity of a family electron-deficient half-sandwich metal complexes.

Condensation of a pyridyl-2-carbaldehyde derivative with 2-(bromoethyl)amine hydrobromide gave tetracyclic pyrido[1,2-a]pyrido[1',2':3,4]imidazo-[2,1-c]-6,7-dihydropyrazinium dications in excellent yields. Crystal structures and NOE data demonstrated the helical character dications, dihedral angles between two pyrido groups ranging from 28-45°. An intermediate synthesis was also characterized. A much brighter emission compared to literature helicenes has been found, quantum yields as high 60...

A series of ruthenium complexes with <italic>η</italic>⁵-C₅(CH₃)₄R and diphosphine ligands have been synthesised evaluated <italic>in vitro</italic> as anticancer agents. IC₅₀ values in the nanomolar range obtained against two types cell lines.

This report presents the first known <italic>p</italic>-cymene ruthenium quinaldamide complexes stabilised by a hydrogen-bridging atom, which are cytotoxic and show induced cancer cell death apoptosis.

This report presents a new library of organometallic iridium(III) compounds the type [Cp*IrCl(L)] (Cp*=pentamethylcyclopentadienyl and L=a functionalized β-ketoiminato ligand) showing moderate to high cytotoxicity against range cancer cell lines. All show increased activity towards colorectal cancer, with preferential observed immortalized p53-null line, HCT116 p53-/-, sensitivity factors (SF) up 26.7. Additionally, have excellent selectivity for cancerous cells when tested normal types,...

Abstract Herein we present a library of fully characterized β‐diketonate and β‐ketoiminate compounds that are functionalized with ferrocenyl moiety. Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF‐7 MDA‐MB‐231), colorectal carcinoma p53 wild type (HCT116 +/+ ) normal prostate (PNT2) cell lines. The more than 18 times the analogues. Against MCF‐7, at meta position up to nine when para position. have increased selectivity towards MCF‐7...