A5027368305- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Metal complexes synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Click Chemistry and Applications
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- Vanadium and Halogenation Chemistry
- Ocular Infections and Treatments
- Antimicrobial agents and applications
- Protease and Inhibitor Mechanisms
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
University of Bradford
2018-2023
University of Pittsburgh at Bradford
2018
A bacteria binding polymer, HB-PNIPAM-van, reduces bioburden of <italic>Staphylococcus aureus</italic> in a model corneal infection.
A range of oxobis(phenyl-1,3-butanedione) vanadium(IV) complexes have been successfully synthesized from cheap starting materials and a simple solvent-free one-pot dry-melt reaction. This direct, straightforward, fast alternative approach to inorganic synthesis has the potential for wide applications. Analytical studies confirm their successful synthesis, purity solid-state coordination, we report use such as drug candidates treatment cancer. After 24 hour incubation A549 lung carcinoma...
The dysregulation of Membrane - type 1 matrix metalloproteinase (MT1-MMP) has been extensively studied in numerous cancer types, and plays key roles angiogenesis, progression, metastasis. MT1-MMP is a predictor poor prognosis osteosarcoma (OS), yet the molecular mechanisms disease progression are unclear. This review provides summary literature relating to gene protein expression (MMP-14) OS clinical samples, evaluates cell lines experimental models, analyses its potential role metastasis...
Abstract Cyclic peptides are important molecules, playing key roles in protein architecture, as chemical probes, and increasingly crucial structural elements of clinically‐useful therapeutics. Herein we report methodology using azodicarboxylates efficient reagents for the facile synthesis cyclic through a disulfide bridge. The utility this approach both solution solid‐phase, compatibility with common amino acid side chain functionalities is demonstrated, resulting good yield purity. This has...
Abstract ICT3205 is a targeted cytotoxic agent, comprised of an MT1-MMP-specific peptide and paclitaxel warhead. Paclitaxel, originally approved in 1992, one the most commonly used chemotherapies for various cancer types, but often characterized by its dose-limiting toxicity low aqueous solubility. Tumor-targeted prodrugs are promising strategy selective delivery taxanes to prostate tumors, especially given results STAMPEDE trial1. Previous work has shown that selectively metabolized tumor...