A5018760782- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- DNA and Nucleic Acid Chemistry
- Lipid Membrane Structure and Behavior
- Healthcare Systems and Technology
- Nanocluster Synthesis and Applications
- Semantic Web and Ontologies
- Cancer Cells and Metastasis
- Digital Platforms and Economics
- Bone Tissue Engineering Materials
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Database Systems and Queries
- Data Management and Algorithms
- Electrospun Nanofibers in Biomedical Applications
- Molecular Sensors and Ion Detection
- Business Strategy and Innovation
- Ocular Surface and Contact Lens
- RNA modifications and cancer
- Blockchain Technology Applications and Security
Indian Institute of Technology Kanpur
2019-2025
Carle Foundation Hospital
2014-2023
University of Illinois Urbana-Champaign
2014-2023
Government of Tamil Nadu
2019-2023
Indian Institute of Management Raipur
2023
Indian Institute of Science Bangalore
2011-2021
Urbana University
2015-2018
Centre of Biomedical Research
2018
Dayalbagh Educational Institute
2018
Maharaja Krishna Chandra Gajapati Medical College and Hospital
2017-2018
Patients with percutaneous coronary intervention generally receive either bare metal stents or drug-eluting to restore the normal blood flow. However, due lack of stent production an individual patient in mind, same level effectiveness may not be possible treating two different clinical scenarios. This study introduces for first time feasibility a patient-specific stenting process constructed from direct 3D segmentation medical images using printing biodegradable polymer-graphene composite...
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report label-free paper-based electrical biosensor chip quantify salivary cortisol at point-of-care (POC) level. A high specificity of the sensor detect with detection limit 3 pg/mL was achieved by conjugating anticortisol antibody (anti-CAB) on top gold (Au) microelectrodes using 3,3′-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) self-assembled monolayer (SAM) agent. The...
Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It known to exhibit properties via inhibiting STAT3 phosphorylation process. However, its poor water solubility and low bioavailability impede clinical application. Herein, we used organoplatinum(II) ← pyridyl coordination-driven self-assembly cucurbit[8]uril (CB[8])-mediated heteroternary host-guest complex formation in concert produce an effective delivery system that transports Cur into cancer...
The most important objective of the present study was to explain why cationic lipid (CL)-mediated delivery plasmid DNA (pDNA) is better than that linear in gene therapy, a question that, until now, has remained unanswered. Herein for first time we experimentally show different types CLs, pDNA, contrast DNA, compacted with large amount its counterions, yielding lower effective negative charge. This feature been confirmed through number physicochemical and biochemical investigations....
Lipoplexes formed by the pEGFP-C3 plasmid DNA (pDNA) and lipid mixtures containing cationic gemini surfactant of 1,2-bis(hexadecyl dimethyl ammonium) alkanes family referred to as C16CnC16, where n=2, 3, 5, or 12, zwitterionic helper lipid, 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) have been studied from a wide variety physical, chemical, biological standpoints. The study has carried out using several experimental methods, such zeta potential, gel electrophoresis, small-angle...
Ligand-induced stabilization of the G-quadruplex DNA structure derived from single-stranded 3'-overhang telomeric is an attractive strategy for inhibition telomerase activity. The agents that can induce/stabilize a sequence into are therefore potential anticancer drugs. Herein we present first report interactions two novel bisbenzimidazoles (TBBz1 and TBBz2) based on Tröger's base skeleton with (G4DNA). These molecules stabilize G4DNA human sequence. Evidence their strong interaction has...
Reversible switching of photoluminescence (PL) carbon nanoparticles (CNP) can be achieved with counterionic macromolecular caging and decaging at the nanoscale. A negatively charged uncoated, "bare" CNP high luminescence loses its PL when positively macromolecules are wrapped around surface. Prepared caged carbons could regain their emission only through interaction anionic surfactant molecules, representing amphiphiles endocytic membranes. This process verified by gel electrophoresis,...
Prostate-specific antigen (PSA) is a commonly used biomarker for the detection of prostate cancer (PCa) and there are numerous data available its invasive in serum whole blood. In this work, an electrochemical sensing method was devised to detect traces PSA human saliva using hybrid nanocomposite graphene nanoplatelets with diblock co-polymers Au electrodes (GRP-PS67-b-PAA27-Au). The pure graphitic composition on filter paper provides significantly high electrical thermal conductivity while...
Photoacoustic imaging has emerged as a promising platform with high tissue penetration depth. However, biodegradable nanoparticles, especially those for photoacoustic imaging, are rare and limited to few polymeric agents. The development of such nanoparticles holds great promise clinically translatable diagnostic biocompatibility. Metabolically digestible inherently probes can be developed from nanoprecipitation biliverdin, naturally occurring heme-based pigment. synthesis composed...
The emergence of multidrug resistance in cancer cells necessitates the development new therapeutic modalities. One way orchestrate energy metabolism and redox homeostasis is through overloaded iron pools directed by regulatory proteins, including transferrin. Here, we demonstrate that targeting using nitrogen-based heterocyclic chelators their complexes efficiently prevents proliferation liver (EC
A cationic amphiphile, cholest-5en-3β-oxyethyl pyridinium bromide (PY(+) -Chol), is able to efficiently disperse exfoliated graphene (GR) in water by the physical adsorption of PY(+) -Chol on surface GR form stable, dark aqueous suspensions at room temperature. The GR-PY(+) suspension can then be used solubilize Tamoxifen Citrate (TmC), a breast cancer drug, water. resulting TmC-GR-PY(+) stable for long time without any precipitation. Fluorescence emission and UV absorption spectra indicate...
Repurposing of existing cancer drugs to overcome their physical limitations, such as insolubility, represents an attractive strategy achieve enhanced therapeutic efficacy and broaden the range clinical applications. Such approach also promises offer substantial cost savings in drug development efforts. Here we repurposed FDA-approved topical agent bexarotene (Targretin), currently limited use for cutaneous manifestations T-cell lymphomas, re-engineer it solid tumor applications by forming...
In this work, we demonstrate the significance of defined surface chemistry in synthesizing luminescent carbon nanomaterials (LCN) with capability to perform dual functions (i.e., diagnostic imaging and therapy). The LCN has been tailored achieve two different varieties: one that a thermoresponsive polymer aids controlled delivery drugs, other fluorescence emission both visible near-infrared (NIR) region can be explored for advanced modes. Although these particles are synthesized using...
In this work, an ultra-sensitive electrochemical-digital sensor chip is devised for potential use as a digital stress analyzer point-of-care testing (POCT) and preventive on-site recording of the hormone 'cortisol', glucocorticoid class steroid present in human saliva. The was interfaced re-configured with high precision impedance converter system (AD5933) used electrochemical spectroscopy (EIS) to evaluate cortisol levels seven saliva samples. To obtain enhanced biological (cortisol)...