A5033746701- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Additive Manufacturing and 3D Printing Technologies
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Viral Infections and Immunology Research
- Graphene and Nanomaterials Applications
- Spectroscopy and Chemometric Analyses
- Metabolomics and Mass Spectrometry Studies
- Carbon Nanotubes in Composites
- Supramolecular Chemistry and Complexes
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Molecular Biology Techniques and Applications
- Near-Field Optical Microscopy
- Advanced Fluorescence Microscopy Techniques
- RNA Interference and Gene Delivery
University of Illinois Urbana-Champaign
2014-2022
In this work, we demonstrate the significance of defined surface chemistry in synthesizing luminescent carbon nanomaterials (LCN) with capability to perform dual functions (i.e., diagnostic imaging and therapy). The LCN has been tailored achieve two different varieties: one that a thermoresponsive polymer aids controlled delivery drugs, other fluorescence emission both visible near-infrared (NIR) region can be explored for advanced modes. Although these particles are synthesized using...
Signal transducer and activator of transcription factor 3 (STAT‐3) is known to be overexpressed in cancer stem cells. Poor solubility variable drug absorption are linked low bioavailability decreased efficacy. Many the drugs regulating STAT‐3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril introduced for enhancing niclosamide, a inhibitor. The host–guest chemistry...
Nearfield spectroscopic imaging techniques can be a powerful tool to map both cellular ultrastructure and molecular composition simultaneously but are currently limited in measurement capability. Resonance enhanced (RE) atomic force microscopy infrared (AFM-IR) offers high-sensitivity measurements, for example, probe-sample mechanical coupling, nonmolecular optical gradient forces, noise overwhelm recorded chemical signals. Here, we analyze the key factors limiting AFM-IR measurements...
Abstract Typically, multiplexing high nanoparticle uptake, imaging and therapy requires careful integration of three different functions a multiscale molecular-particle assembly. Here, we present simpler approach to by utilizing one component the system for multiple functions. Specifically, successfully synthesized characterized colloidal carotene carbon (C 3 -NP), in which single functional molecule served threefold purpose. First, presence moieties promoted passage particle through cell...
Rapid measurements of protein and oil content are important for a variety uses, from sorting soybeans at the point harvest to feedback during soybean meal production. In this study, our goal is develop simple protocol permit rapid robust quantitative prediction constituents using transmission Raman spectroscopy (TRS). To approach, we systematically varied various elements measurement process provide diverse test bed. First, utilized an in-house-built benchtop TRS instrument such that...
Precise freeform microchannels within an aqueous environment have several biomedical applications but remain a challenge to fabricate. Carbohydrate glass materials shown potential for three-dimensionally (3D) printing precise, microscale structures and are suitable as sacrificial material reconstruct complex channel architectures, due the rapid dissolution kinetics in hydrogels environment, protective coatings required. Here, conformal were applied carbohydrate via surface-initiated...
Myocardial fibrosis underpins a number of cardiovascular conditions and is difficult to identify with standard histologic techniques. Challenges include imaging, defining an objective threshold for classifying as mild or severe, understanding the molecular basis these changes.To develop novel, rapid, label-free approach accurately measure quantify extent in cardiac tissue using infrared spectroscopic imaging.We performed imaging combined that advanced machine learning-based algorithms assess...
Drug (PTX)-loaded luminescent carbon nanoparticles (LCNs) are passivated with a thermoresponsive polymer (PNIPAM) inside melanoma cells. On page 4691, R. Bhargava, D. Pan, and co-workers acquire such images using confocal fluorescence techniques. A representative cartoon of the is shown in black, where white green shells represent anti-cancer drug (PTX: molecular structure shown) PNIPAM coating, respectively. The cells, upon internalizing particles under physiological conditions, trigger...
A theranostic, enzymatically biodegradable nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT-3 inhibitor. On page 5845, D. Pan and co-workers reveal that, overall, supramolecular chemistry nanocarbon acts as novel arsenal inhibition in vitro vivo provides signature intracellular tracking.