A5055439627- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Innovations in Medical Education
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Infrared Thermography in Medicine
- Cardiac Imaging and Diagnostics
- Blood transfusion and management
- Renal Transplantation Outcomes and Treatments
- Health and Medical Research Impacts
- Surgical Simulation and Training
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Aortic Disease and Treatment Approaches
- Diversity and Career in Medicine
- Orthopaedic implants and arthroplasty
Oregon Health & Science University
2015-2024
University of Portland
2018-2022
Oregon Health and Science University Hospital
2020
Stanford University
2000-2018
Stanford Medicine
2003-2014
Fistula Foundation
2012
San Diego Cardiac Center
2005
University of California, San Diego
2004
Texas A&M University
2004
Cardiovascular Institute of the South
2004
The fibroproliferative reaction to acute lung injury may limit restoration of normal function and increase mortality in patients with injury. A biologic marker collagen synthesis the be useful for studying pathogenesis identifying who are at high risk death might benefit from new therapeutic modalities. Using an immunoassay, type III procollagen NH2 terminal peptide was measured pulmonary edema fluid 44 either or hydrostatic (control group) within first 24 h after endotracheal intubation...
Background— Better understanding of the precise 3-dimensional geometric changes mitral valvular-ventricular complex in chronic ischemic regurgitation (CIMR) is needed order to devise better surgical repair techniques. We hypothesized that after inferior myocardial infarction would be different hearts developed CIMR compared with those did not. Methods and Results— Twenty-four sheep underwent coronary snare marker placement (annulus, papillary muscles, anterior posterior leaflets). After 8...
Mitral valvular-ventricular continuity is important for left ventricular (LV) systolic function, but the specific contributions of anterior leaflet second-order "strut" chordae are unknown.Eight sheep had radiopaque markers implanted to silhouette LV, annulus, and papillary muscles (PMs); 3 transmural bead columns were inserted into mid-lateral wall between PMs. The strut encircled with exteriorized wire snares. Three-dimensional marker images hemodynamic data acquired before after chordal...
Although it is well known that beta-adrenergic agonist stimulation increases alveolar epithelial sodium and fluid transport, not whether the beta-1 or beta-2 receptor mediates this effect. Two clinically relevant agonists, dopamine (beta-1 agonist) dobutamine were used to define contribution of these two beta-receptors stimulated clearance from air spaces lungs. Alveolar was measured in anesthetized, ventilated rats over one hour after instilling an isosmolar 5% albumin solution Ringer's...
Chronic ischemic mitral regurgitation (CIMR) is associated with heart failure that continues unabated whether the valve repaired, replaced, or ignored. Altered left ventricular (LV) torsion dynamics, deleterious effects on transmural gradients of oxygen consumption and diastolic filling, may play a role in cycle failing myocardium. We hypothesized LV dilatation perturbations would be greater animals which CIMR developed after inferior myocardial infarction (MI) than those it did not.8+/-2...
Three-dimensional dynamics of the 3 individual scallops within posterior mitral leaflet during acute ischemic regurgitations have not been previously measured.Radiopaque markers were sutured to annulus, papillary muscle tips, and edges in 13 sheep. Immediately postoperatively, under open-chest conditions, 3-D marker coordinates obtained using high-speed biplane videofluoroscopy before echocardiographically verified regurgitation produced by occlusion left circumflex coronary artery.During...
Underlying left ventricular (LV) dysfunction contributes to poor survival after operation correct ischemic mitral regurgitation (IMR). Many surgeons do not appreciate that a key component of the Bolling undersized ring annuloplasty concept is decrease LV wall stress by altering shape, but precise 3-dimensional (3-D) geometric data exist substantiating this effect. We tested hypothesis annular reduction decreases regional circumferential radius curvature (ROC) in model acute IMR.Eight adult...