A5005551553- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and bioactivity of alkaloids
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
- Synthesis and Reactivity of Heterocycles
- Medicinal Plants and Neuroprotection
- Bioactive Compounds and Antitumor Agents
- Vitamin C and Antioxidants Research
- Metal complexes synthesis and properties
- Phytochemicals and Medicinal Plants
- Biochemical and Molecular Research
- Synthesis and Reactions of Organic Compounds
- Melanoma and MAPK Pathways
- Enzyme function and inhibition
- Crystallography and molecular interactions
- Phytochemicals and Antioxidant Activities
- Synthesis of Tetrazole Derivatives
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Essential Oils and Antimicrobial Activity
Savitribai Phule Pune University
2022-2025
National Institute of Pharmaceutical Education and Research
2012-2022
Aims Community College
2022
Bharati Vidyapeeth Deemed University
2021-2022
Amrita Vishwa Vidyapeetham
2022
University of Hyderabad
2017
Indian Institute of Chemical Technology
2014-2016
National Institute of Pharmaceutical Education and Research
2015
Abstract A series of β‐carboline hybrids bearing a substituted phenyl and chalcone/( N‐ acetyl)‐pyrazole moiety at the C1 C3 positions, respectively, was designed, synthesized, evaluated for anticancer activity. These new hybrid molecules showed significant cytotoxic activity, with IC 50 values ranging from <2.0 μ M to 80 , structure–activity relationships (SAR) associated substitutions positions 1 3 these clearly addressed. Further, induction apoptosis confirmed by Annexin V‐FITC,...
A series of β-carboline–benzimidazole conjugates were synthesized using lanthanum nitrate as a novel catalyst and evaluated for their anticancer activity.
A series of chalcone-linked pyrazolo[1,5-<italic>a</italic>]pyrimidines was synthesized and evaluated for antiproliferative activity.
Garuga pinnata a tree spotted in the Asian continent constitutes of constellation phytochemicals whole from which alcoholic extract leaf is abundant source. The namely Amentoflavone, Garuganin-1, Garuganin-3, Garuganin-4, and Garuganin-5 were considered for study as they have anti-Alzheimer's potential but biological target has not been reported. So, to identify scrutinized by employing silico methodologies molecular docking, dynamics simulation, ADMET prediction. Molecular docking revealed...
A series of novel imidazo[1,5-a]pyridine–PBD conjugates were synthesized and evaluated for their antitumor activity in breast cancer cell line (MCF-7). Interestingly, all the compounds showed enhanced DNA binding ability. These significant as deduced by MTT proliferation assay amongst them, 13f 13g exhibit promising activity. G2/M phase cycle arrest was observed on treatment cells (MCF-7) with 2 μM concentration these compounds. Moreover, accumulation G0 (apoptotic) upon increase to 4 μM....
A series of 2-anilinopyridyl–triazole conjugates (6a–t) were prepared and evaluated for their cytotoxic activity against a panel three human cancer cell lines. Among them compounds 6q, 6r 6s showed significant with IC50 values ranging from 0.1 to 4.1 μM. Structure–activity relationships elucidated various substitutions on these conjugates. Flow cytometric analysis revealed that arrest the cycle at G2/M phase induce death by apoptosis. The tubulin polymerization assay immunofluorescence (6q,...
This research manuscript aims to find the most effective epidermal growth factor receptor (EGFR) inhibitors from millions of in house compounds through Machine Learning (ML) techniques. ML-based structure activity relationship (SAR) models were validated predict biological untested novel molecules. Six ML algorithms, including k nearest neighbour (KNN), decision tree (DT), Logistic Regression, support vector machine (SVM), multilinear regression (MLR), and random forest (RF), used build for...
Abstract: Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on health of patients. The iron transport mechanism in mycobacterium plays pivotal role bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase member MST family and enzyme distrait mammals. It first for synthesis mycobactin (siderophores) which determinant transport. present all-embracing review provides overall coverage biological...
A series of imidazothiadiazole–benzimidazole conjugates (<bold>3a–z</bold>) were synthesized and evaluated for their cytotoxic activity against a set four selected human cancer cell lines. Compounds<bold>3b</bold>and<bold>3y</bold>exhibited significant antiproliferative the ME-180 (cervical) line.
Formulation and evaluation of fast dissolving tablets Granisetron hydrochloride by vacuum drying techniqueBasawaraj S.Patil, N.G.Raghavendra Rao
Disruption of tubulin polymerization and the docked pose of<bold>5k</bold>in colchicine binding site tubulin.
Cancer is an unimpeded growth of cells leading to metathesis cancer and eventually spread throughout the body. PIM kinases are members serine threonine kinase playing role in progression, differentiation proliferation. Till date there no single drug targeting PIM-1 market, that has made itself a target limelight for discover new anticancer agents. The contemporary research focusses on development inhibitors by application ligand-based structure-based perspective discovery namely 3D-QSAR,...