Diabetic neuropathy (DN) is one of the most common long-term complications diabetes mellitus and clinically can be characterized by an elevated nociceptive response with electrophysiological conduction abnormalities. The present investigation was designed to evaluate neuroprotective effect hesperidin against STZ induced diabetic neuropathic pain in laboratory rats.DN Sprague-Dawley rats (150-200 g) intraperitoneal administration streptozotocin (STZ) (55 mg/kg, p.o.). Rats were divided into...

Context: Wound healing is a consequence of complex process involving inflammatory, proliferative, and remodeling phases. Naringin, flavanone glycoside, associated with modulation various oxido-inflammatory growth factors.Aim: The aim this study to evaluate the wound-healing activity naringin ointment formulation (NOF) on experimental wound models.Materials methods: A soft paraffin-based cream containing 1, 2, 4% (w/w) was formulated evaluated for physicochemical characters. Excision wounds...

Background: Gentamicin (GM) is the commonly used antibiotics against Gram-negative infection, but nephrotoxic potential of drug limit its clinical interest. The aim this study was to investigate protective effect berberine (BER) GM-induced nephrotoxicity and possible underlying mechanisms. Material methods: rats were divided into various group, namely normal, GM-control, GM + BER (10, 20, 40 mg/kg). Nephrotoxicity induced by intraperitoneal administration (120 mg/kg) for 7 consecutive days....

Chronic exposure of a naturally occurring metal arsenic leads to renal and hepatic diseases. Naringin, flavanone glycoside, possesses anti-inflammatory anti-oxidant potential. The aim this investigation was evaluate the protective effect naringin against arsenic-induced toxicity in rats. Renal induced rats by sodium arsenite (5 mg/kg, p.o.). Rats were treated orally with either vehicle or (20, 40, 80 mg/kg) Coenzyme Q10 (10 for 28 days. Various biochemical, histological, molecular biomarkers...

Context: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known to cause hepatic renal toxicity at a higher dose. Naringin, bioflavonoid possesses multiple pharmacological properties such as antioxidant, anti-inflammatory, anti-hyperlipidemic activity. Objective: To evaluate the effect of naringin against APAP-induced toxicity. Materials methods: Male Wistar albino rats (180–220 g) were divided into various groups, was induced by APAP (700 mg/kg, p.o., 14 days). Naringin...

Ulcerative colitis (UC) is a chronic immune-inflammatory disorder characterized by oxido-nitrosative stress, the release of pro-inflammatory cytokines and apoptosis. Ferulic acid (FA), phenolic compound considered to possess potent antioxidant, anti-apoptotic anti-inflammatory activities. The aim evaluate possible mechanism action FA against trinitrobenzensulfonic (TNBS) induced ulcerative in rats. UC was Sprague-Dawley rats (150-200 g) intrarectal administration TNBS (100 mg/kg)....

Fenugreek (Trigonella foenum graecum) seed extract is a bioactive ingredient of many food supplements. Hence, there need for systematic assessment the quality published toxicological studies its use in human health, hazard consideration, and risk assessment. The aim present investigation was to determine reliability fenugreek by using ToxRTool (Toxicological data tool). A comprehensive literature search conducted PubMed, EMBASE, Cochrane Library, CPCI-S, ICTRP, Ovid, Google Scholar till...

To elucidate the ameliorative effect of hydroalcoholic extract leaves Hibiscus rosa sinensis (HRS) in acetic acid induced experimental colitis male wistar rats.The animals were administered with 2 mL (4%) via intra rectal. The divided into various treatment groups (n=6). Prednisolone was used as standard drug and HRS at a dose 50, 100 200 mg/kg p.o. control group received 1 vehicle (distilled water). Ulcer area, ulcer index, spleen weight, colon weight to length ratio, macroscopic score,...

Type-A procyanidine polyphenols (TAPP) are reported to have immunomodulatory and anti-inflammatory potential in vitro. The objective of present work is evaluate TAPP extracted from Cinnamon (Cinnamomum zeylanicum) bark animal models inflammation rheumatoid arthritis rats. Carrageenan-induced rat paw edema (CPE) adjuvant induced established (AIA), rats were used as the experimental for respectively. Analgesic activity was evaluated Randall–Selitto assay AIA showed significant effect at dose...

Abstract The aim of the present investigation was to evaluate effect C oenzyme Q 10 and its combination with vitamin E in alcohol‐induced chronic neuropathic pain. Male W istar rats were orally treated alcohol (10 g/kg, 35% v/v, b.i.d.) for weeks. Coenzyme (25, 50, 100 mg/kg) (100 coadministered 1 h after ethanol administration Various nerve functions, biochemical, molecular parameters assessed. Chronic weeks resulted significant development Treatment (50 showed dose dependently increased...

Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) an important source oxidative in myocardium. We sought to determine whether MAO-A plays a major role modulating DCM. Diabetes was induced Wistar rats by single intraperitoneal injection streptozotocin (STZ). To investigate development pathophysiological features DCM, hyperglycemic and age-matched control were treated or without...

Ischemic acute renal failure is a condition that extends subsequent to sudden and momentary fall in overall or regional blood flow the kidney. The present investigation was deliberated scrutinize renoprotective potential of berberine animal model ischemia reperfusion (RIR) induced dent via assessment various biochemical molecular biomarkers. Male Wistar rats were anesthetized right kidney removed through small flank incision. Renal persuaded uni-nephrectomized by occlusion left artery for 45...