A5030188730- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Curcumin's Biomedical Applications
- Synthesis and Biological Evaluation
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Pharmacological Effects of Natural Compounds
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Bone Metabolism and Diseases
- Advancements in Transdermal Drug Delivery
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Quinazolinone synthesis and applications
- NF-κB Signaling Pathways
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Biological Activities
- Piperaceae Chemical and Biological Studies
- RNA Interference and Gene Delivery
- Drug-Induced Hepatotoxicity and Protection
National Institute of Pharmaceutical Education and Research
2017-2025
National Institute of Pharmaceutical Education and Research
2013-2023
National Institute of Pharmaceutical Education and Research
2013-2019
Osmania University
2016
Indian Institute of Chemical Technology
2007-2014
National University of Singapore
2011-2013
National Institute of Nutrition
2013
Abstract Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type is more aggressive and tends to reoccur often than HER2-negative cancer. In this study, we synthesized trastuzumab (TZ)-grafted dendrimers improve delivery docetaxel (DTX) HER2-positive cells. Bioconjugation TZ on the surface was performed using a heterocrosslinker, MAL-PEG-NHS. For imaging cells, were also conjugated fluorescein isothiocyanate. Comparative in vitro...
Abstract Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of CD for treatment triple negative breast cancer (TNBC) is unclear. This study aims to examine cytotoxic investigate human TNBC cells. The results show that exhibits cytotoxicity by inducing apoptosis cell cycle arrest cells via modulation Bcl‐2, Bax, cyt‐C, cleaved caspase‐3, PARP. We find significantly increases expression epithelial...
Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator inflammation. However, very little is known about its effect on intestinal The aim present study was to investigate potential protective intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation 3 doses 1 mg/Kg (lower dose), 5 (medium and 10 (higher dose) saline performed daily. Uridine at medium high dose significantly reduced...
We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5F) cells against alloxan-induced apoptosis in vitro and type 1 diabetes mellitus (type DM) vivo if so, mechanism of this beneficial action.In study was conducted using RIN5F while performed Wistar rats. The effect PUFAs, cyclo-oxygenase lipoxygenase inhibitors, various eicosanoids PUFAs metabolites: lipoxin A4 (LXA4), resolvin D2 protectin cytotoxicity to DM studied. Expression PDX1, P65 NF-kB IKB Nrf2,...