A5064112860- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Medicinal Plants
- Lipid Membrane Structure and Behavior
- Pharmacological Effects of Natural Compounds
- Cancer Mechanisms and Therapy
- Nigella sativa pharmacological applications
- Bioactive Compounds and Antitumor Agents
- Bone Metabolism and Diseases
- Mosquito-borne diseases and control
- Click Chemistry and Applications
- Phytochemistry and Biological Activities
- Cancer therapeutics and mechanisms
- Biochemical effects in animals
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Synthesis and Biological Evaluation
- Piperaceae Chemical and Biological Studies
- Wnt/β-catenin signaling in development and cancer
- Natural Compound Pharmacology Studies
Amrita Institute of Medical Sciences and Research Centre
2024-2025
Amrita Vishwa Vidyapeetham
2022-2025
ICMR-National Institute of Virology
2021-2024
National Institute of Pharmaceutical Education and Research
2014-2023
Linköping University
2017-2020
National Institute of Pharmaceutical Education and Research
2020
National Institute of Pharmaceutical Education and Research
2015-2017
Indian Institute of Chemical Technology
2014
AbstractBackground: Delivery of drugs to brain is a subtle task in the therapy many severe neurological disorders. Solid lipid nanoparticles (SLN) easily diffuse blood–brain barrier (BBB) due their lipophilic nature. Furthermore, ligand conjugation on SLN surface enhances targeting efficiency. Lactoferin (Lf) conjugated system first time attempted for effective this study.Purpose: Preparation Lf-modified docetaxel (DTX)-loaded proficient delivery DTX brain.Methods: DTX-loaded were prepared...
Abstract Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of CD for treatment triple negative breast cancer (TNBC) is unclear. This study aims to examine cytotoxic investigate human TNBC cells. The results show that exhibits cytotoxicity by inducing apoptosis cell cycle arrest cells via modulation Bcl‐2, Bax, cyt‐C, cleaved caspase‐3, PARP. We find significantly increases expression epithelial...
Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator inflammation. However, very little is known about its effect on intestinal The aim present study was to investigate potential protective intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation 3 doses 1 mg/Kg (lower dose), 5 (medium and 10 (higher dose) saline performed daily. Uridine at medium high dose significantly reduced...
Chikungunya virus (CHIKV), a serious health problem in several tropical countries, is the causative agent of chikungunya fever. Approved antiviral therapies or vaccines for treatment prevention CHIKV infections are not available. As diverse natural phenolic compounds have been shown to possess activities, we explored activity α-Mangostin, xanthanoid, against infection.The vitro prophylactic and therapeutic effects α-Mangostin on replication Vero E6 cells were investigated by administering it...
Introduction: Cerebrovascular and cardiovascular diseases are major causes of global mortality, with significant impact in India. Clopidogrel, an antiplatelet prodrug, requires activation by CYP enzymes to inhibit platelet activation. Clopidogrel resistance, affecting 4-30% patients, is often due CYP2C19 gene variations, among other factors. This study explores genetic variants associated clopidogrel resistance improve personalized therapy for thrombotic conditions. Objective: To evaluate...
Rheumatoid arthritis (RA), a chronic inflammatory disease, is characterized by joint swelling, cartilage erosion, and bone destruction. This study investigated the therapeutic efficacy of Carnosic acid (CA), natural compound with anti-inflammatory antioxidant properties, in an adjuvant-induced model.