A5101859152- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Malaria Research and Control
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Virology and Viral Diseases
- HIV Research and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Vector-borne infectious diseases
- RNA and protein synthesis mechanisms
- Hepatitis C virus research
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Dengue and Mosquito Control Research
- Hepatitis B Virus Studies
- Papaya Research and Applications
- RNA Interference and Gene Delivery
ICMR-National Institute of Virology
2015-2024
Academy of Scientific and Innovative Research
2024
Indian Agricultural Research Institute
2023
Shiv Nadar University
2023
Indian Institute of Technology Roorkee
2023
Re-emergence of Chikungunya (CHIK), caused by CHIK virus, was recorded in India during 2005–2006 after a gap 32 years, causing 1.3 million cases 13 states. Several islands the Indian Ocean reported similar outbreaks same period. These were attributed to African genotype virus. To examine relatedness isolates (IND-06) with Reunion Island (RU), full-genome sequences five virus representative different states determined. In addition, an isolate obtained from mosquitoes year 2000 (Yawat-2000),...
Chikungunya virus (CHIKV), a serious health problem in several tropical countries, is the causative agent of chikungunya fever. Approved antiviral therapies or vaccines for treatment prevention CHIKV infections are not available. As diverse natural phenolic compounds have been shown to possess activities, we explored activity α-Mangostin, xanthanoid, against infection.The vitro prophylactic and therapeutic effects α-Mangostin on replication Vero E6 cells were investigated by administering it...
Metagenomic analysis of Aedes aegypti and Ae. albopictus mosquitoes from diverse geographical regions India revealed the presence several insect viruses human interest. Most abundant reads found in were Phasi Charoen-like virus (PCLV), Choristoneura fumiferana granulovirus (CfGV), Cell fusing agent (CFAV), Wenzhou sobemo-like 4 (WSLV4), whereas WSLV4 CfGV constituted highest percentage viromes. Other that low included Hubei mosquito 2 (HMV2), Porcine astrovirus (PAstV4), Wild Boar (WBAstV)....
Abstract Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of disease. In order to improve efficacy known drugs, combining drugs is promising approach. The current study was undertaken explore activity combination were reported anti-CHIKV activity. We explored effect different combinations six effective (2-fluoroadenine, emetine, lomibuvir,...
Dengue virus (DENV), a member of the family Flaviviridae, is threat for global health as it infects more than 100 million people yearly. Approved antiviral therapies or vaccines treatment prevention DENV infections are not available. In present study, natural compounds were screened their activity against by in vitro cell line-based assay. α-Mangostin, xanthanoid, was observed to exert DENV-2 under pre-, co- and post-treatment testing conditions. The determined foci forming unit (FFU) assay,...
Dengue and chikungunya are two important mosquito-borne infections which known to occur extensively in tropical subtropical areas. Presently, there is no treatment for these viral diseases. In vitro antiviral screening of 25 extracts prepared from the plants Vitex negundo, Plumeria alba, Ancistrocladus heyneanus, Bacopa monnieri, Anacardium occidentale, Cucurbita maxima, Simarouba glauca, Embelia ribes using different solvents four purified compounds (anacardic acid, chloroquinone,...
Widespread infection of highly pathogenic avian influenza A H5N1 was reported from backyard and commercial poultry in West Bengal (WB), an eastern state India early 2008. Infection gradually spread to Tripura, Assam Sikkim, the northeastern states, with 70 outbreaks between January 2008 May 2009. Whole genome sequence analysis three isolates WB, one isolate Tripura along hemagglutinin (HA) neuraminidase (NA) genes 17 other performed during this study. In HA gene phylogenetic tree, all...
Abstract The Kyasanur Forest Disease (KFD) has become a major public health problem in the State of Karnataka, India where disease was first identified and Tamil Nadu, Maharashtra, Kerala, Goa covering Western Ghats region India. incidence positive cases distribution virus (KFDV) different geographical regions raises need to understand evolution spatiotemporal transmission dynamics. Phylogeography analysis based on 48 whole genomes (46 from this study) additionally 28 E-gene sequences KFDV...
Viruses belonging to the Coronaviridae family have a single-stranded positive-sense RNA with poly-A tail. The genome has length of ~29.9 kbps, which encodes for genes that are essential cell survival and replication. Different evolutionary constraints constantly influence codon usage bias (CUB) different genes. A virus optimizes its fit host environment on it savors. This study is comprehensive analysis CUB encoded by viruses family. methods including relative synonymous (RSCU), an Effective...
Several phylogenetic classification systems have been devised to trace the viral lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, inconsistency in nomenclature limits uniformity its epidemiological understanding. This study provides an integration existing classifications and describes evolutionary trends SARS-CoV-2 strains circulating India.
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes . There are no licenced antivirals or vaccines for treatment prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics battle pathogens. In the present study, anti CHIKV activity fourteen FDA-approved drugs was investigated in vitro and silico approaches. Focus-forming unit assay, immunofluorescence test, quantitative RT-PCR assay were used assess inhibitory...
The Chandipura virus (CHPV) belonging to the Vesiculovirus genus and Rhabdoviridae family, has recently been associated with a number of encephalitis epidemics, high mortality in children, different parts India. No full length genome sequences CHPV isolates were available GenBank little is known about molecular markers for pathogenesis. In present study, we provide complete genomic four from epidemics during 2003-2007. These along deduced sequence prototype isolate 1965 analysed using...
Influenza surveillance in different wild bird populations is critical for understanding the persistence, transmission and evolution of these viruses. Avian influenza (AI) was undertaken migratory resident birds during period 2007-2008, view outbreaks highly pathogenic AI (HPAI) H5N1 poultry India since 2006. In this study, we present whole genome sequence data along with genetic virological characterization an A(H11N1) virus isolated from aquatic first time India. The low pathogenicity...