A5022133740- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Outbreaks Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- COVID-19 diagnosis using AI
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Plant Virus Research Studies
- Travel-related health issues
ICMR-National Institute of Virology
2016-2025
B. J. Medical College & Sassoon Hospital
2022-2024
Government Medical College
2023-2024
Government of Maharashtra
2024
Directorate of Health
2024
Indian Institute of Science Education and Research Pune
2023
Indian Council of Medical Research
2014-2022
CM Hospital
2022
All India Institute of Medical Sciences
2022
Regional Medical Research Centre
2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state Maharashtra late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) B.1.1.7 (Alpha)
As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic expands, genomic epidemiology and whole genome sequencing are being used to investigate its transmission evolution. Against backdrop of emergence "variants concern" (VOCs) during December 2020 an upsurge in a state western part India since January 2021, analysis spike protein mutations using sequence structural approaches were undertaken identify possible new variants gauge fitness current circulating...
Abstract As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic expands, genomic epidemiology and whole genome sequencing are being constantly used to investigate its transmissions evolution. In backdrop of emergence “variants concern” (VOCs) during December 2020 an upsurge in a state western part India since January 2021, analysis spike protein mutations using sequence structural approaches was undertaken identify possible new variants gauge fitness current...
Background Influenza surveillance is an important tool to identify emerging/reemerging strains, and defining seasonality. We describe the distinct patterns of circulating strains virus in different areas India from 2009 2013. Methods Patients ten cities presenting with influenza like illness out-patient departments dispensaries/hospitals hospitalized patients severe acute respiratory infections were enrolled. Nasopharangeal swabs tested for viruses by real-time RT-PCR, subtyping; antigenic...
ABSTRACT Background We report the clinical efficacy against COVID-19 infection of BBV152, a whole-virion inactivated SARS-CoV-2 vaccine formulated with Toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG). Methods did double-blind, randomised, multicentre, phase 3 trial in 25 Indian hospitals evaluate efficacy, safety, and immunological lot consistency BBV152. Healthy adults (age 18–98 years) randomised 1:1 using computer-generated randomisation scheme received two...
India has been reporting the cases of coronavirus disease 2019 (COVID-19) since January 30, 2020. The Indian Council Medical Research (ICMR) formulated and established laboratory surveillance for COVID-19. In this study, an analysis data was done to describe testing performance descriptive epidemiology COVID-19 by time, place person.The were extracted from 22 April frequencies described over time place. We (epidemic curve date specimen collection; seven-day moving average), (area map) person...
ABSTRACT Background The recent emergence of new SARS-CoV-2 lineage B.1.617 in India has been associated with a surge the number daily infections. This variant combination specific mutations L452R, E484Q and P681R reported to possibly enhance transmissibility likelihood escaping immunity. We investigated viral load pathogenic potential B.1.617.1 Syrian golden hamsters. Methods Two groups hamsters (9 each) were inoculated intranasally SARS CoV-2 isolates, B.1 (D614G) respectively. animals...
Abstract A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV on basis challenges and limitations our previous proposals future genomic surveillance. From a high-quality curated dataset 1,480 HRSV-A 1,385 HRSV-B genomes submitted to GenBank GISAID (https://www.gisaid.org) public sequence databases through March 2023, we categorized HRSV-A/B sequences into...
Abstract A globally implemented unified classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. Here, we formulate global consensus of HRSV based on challenges and limitations our previous proposals future genomic surveillance. From a high-quality dataset 1,480 HRSV-A 1,385 HRSV-B genomes submitted to NCBI GISAID up March 2023, categorized HRSV-A/B sequences into lineages phylogenetic clades amino acid markers. We defined 24 within 16 HRSV-B,...
The Influenza A pandemic H1N1 2009 (H1N1pdm) virus appeared in India May and thereafter outbreaks with considerable morbidity mortality have been reported from many parts of the country. Continuous monitoring genetic makeup is essential to understand its evolution within country relation global diversification track mutations that may affect behavior virus.H1N1pdm viruses were isolated both recovered fatal cases representing major cities sequenced. Phylogenetic analyses six concatenated...
We have isolated the new severe acute respiratory syndrome coronavirus-2 variant of concern 202 012/01 from positive coronavirus disease 2019 cases that travelled UK to India in month December 2020. This emphasizes need for strengthened surveillance system limit local transmission this variant.
The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution virus clades and variants circulating different parts India between January August 2020. NPS/OPS from representative positive states union territories were collected every month through VRDLs country analyzed using next-generation sequencing. Epidemiological analysis 689 SARS-CoV-2 clinical samples revealed GH GR to be predominant northern...
Background SARS-CoV-2 has evolved rapidly, resulting in the emergence of lineages with a competitive advantage over one another. Co-infections different can give rise to recombinant lineages. To date, XBB lineage is most widespread worldwide, recently named XBB.1.16 causing surge number COVID-19 cases India. Methodology The present study involved retrieval genome sequences from India (between December 1, 2022 and April 8, 2023) through GISAID; were curated, followed by phylogenetic analysis....
Background: In August 2023, the BA.2.86 SARS-CoV-2 variant, with over 30 spike protein mutations, emerged amidst global dominance of XBB sub-lineages. It evolved into JN.1 by late spreading across 71 countries. JN.1, distinct for its L455S mutation, significantly dominated sequences, raising concerns transmission and clinical impact. The study investigates JN.1's severity effect on hospital admissions in Maharashtra, India. Methodology: present involved 3,150 curated Indian whole genome...
Background Pandemic influenza A (H1N1) 2009 has posed a serious public health challenge world-wide. In absence of reliable information on severity the disease, nations are unable to decide appropriate response against this disease. Methods Based results laboratory investigations, attendance in outpatient department, hospital admissions and mortality from cases like illness 1 August 31 October Pune urban agglomeration, risk hospitalization case fatality ratio were assessed determine pandemic...
Please cite this paper as: Chadha et al. (2011) Multi site Virological Influenza Surveillance in India: 2004–2008. and Other Respiratory Viruses 6(3), 196–203. Background surveillance is important to identify circulating, emerging/reemerging strains unusual epidemiological trends. With these objectives, a multisite human influenza network was initiated India 2004. Methods Epidemiologic data throat swabs for laboratory testing were collected from patients with influenza‐like illness (ILI)...
The main route of the transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are through pathways and close contact human-to-human. While information about other modes is comparatively less, some published literature supporting likelihood a fecal-oral mode has been accumulating. diagnosis SARS-COV-2 infected cases based on real-time reverse transcription-PCR (RT-PCR). fecal excretion reported frequently, however, role viral load with severity disease not yet clear. Our...
SARS-CoV-2/influenza virus co-infection studies have focused on hospitalized patients who usually had grave sequelae. Here, we report cases from both community and hospital settings reported through integrated ILI/SARI (Influenza Like Illness/Severe Acute Respiratory Infection) sentinel surveillance established by the Indian Council of Medical Research. We describe disease progression outcomes in these cases. Out 13,467 samples tested 4 July 2021-31 January 2022, only 5 (0.04%) were 3...
Background SARS-CoV-2 has evolved to produce new variants causing successive waves of infection. Currently, six are being monitored by the World Health Organization that replacing BA.5. These include BF.7 (BA.5 + R346T in spike), BQ.1 (and BQ.1.1, with BA.5 R346T, K444T, N460K mutations BA.2.75 (including BA.2.75.2 and CH.1.1), XBB XBB.1.5). more immune evasive have spread quickly throughout world. Concerning potential severity infections caused these variants, present study describes...