A5055765089- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Veterinary Oncology Research
- Microbial infections and disease research
- Mycotoxins in Agriculture and Food
- Vector-borne infectious diseases
- Animal Nutrition and Physiology
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Genetic and phenotypic traits in livestock
- Natural Antidiabetic Agents Studies
- Diverse Scientific Research Studies
- Coccidia and coccidiosis research
- Animal Disease Management and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Animal Virus Infections Studies
- Comparative Animal Anatomy Studies
- Vector-Borne Animal Diseases
- Phytochemicals and Medicinal Plants
- Cardiovascular Conditions and Treatments
- Virus-based gene therapy research
- Rabies epidemiology and control
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
Maharashtra Animal and Fishery Sciences University
2022-2024
Krantisinh Nana Patil College of Veterinary Science
2017-2023
Kerala Veterinary and Animal Sciences University
2019-2023
Abstract The COVID-19 pandemic is a global health crisis that poses great challenge to the public system of affected countries. Safe and effective vaccines are needed overcome this crisis. Here, we develop assess protective efficacy immunogenicity an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups five animals each. One group was administered placebo, while three immunized with different candidates BBV152 at 0 14 days. All challenged fourteen...
The availability of a safe and effective vaccine would be the eventual measure to deal with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) threat. Here, we have assessed immunogenicity protective efficacy inactivated SARS-CoV-2 candidates BBV152A, BBV152B, BBV152C in Syrian hamsters. Three dose vaccination regimes induced significant titers SARS-CoV-2-specific IgG neutralizing antibodies. BBV152A BBV152B remarkably generated quick robust immune response. Post-SARS-CoV-2...
ABSTRACT Background The recent emergence of new SARS-CoV-2 lineage B.1.617 in India has been associated with a surge the number daily infections. This variant combination specific mutations L452R, E484Q and P681R reported to possibly enhance transmissibility likelihood escaping immunity. We investigated viral load pathogenic potential B.1.617.1 Syrian golden hamsters. Methods Two groups hamsters (9 each) were inoculated intranasally SARS CoV-2 isolates, B.1 (D614G) respectively. animals...
SARS-CoV-2 Omicron variant is rampantly spreading across the globe. We assessed pathogenicity and immune response generated by BA.1.1 sub-lineage of [Omicron (R346K) variant] in 5 to 6-week old Syrian hamsters compared observations with that Delta infection.Virus shedding, organ viral load, lung disease were sequentially assessed.The characteristics found be similar infection like replication respiratory tract interstitial pneumonia. The infected demonstrated lesser body weight reduction RNA...
Over two billion people around the world suffer from anemia. Majority of populations are using dietary supplements and herbal medicines for management anemic conditions. Many polyherbal formulations such as Raktavardhak Kadha (RK), available in Indian market a nutritional supplement herbal-based medicine The present study is aimed at investigating antianemic potential formulation, RK, against phenylhydrazine-induced anemia rats. RK was subjected to preliminary phytochemical analysis iron...
Abstract The COVID-19 pandemic is a global health crisis that has severely affected mankind and posed great challenge to the public system of countries. availability safe effective vaccine need hour overcome this crisis. Here, we have developed assessed protective efficacy immunogenicity an inactivated SARS-CoV-2 (BBV152) in rhesus macaques (Macaca mulata). Twenty were divided into four groups five animals each. One group was administered placebo while three immunized with different...
Purpose: Development of delivery tool for the existing antiretroviral drugs against neuronal-AIDS in itself is a big challenge because blood-brain-barrier (BBB). Aim present research to formulate efavirenz (EFV) based mucoadhesive microemulsion (EMME) and investigates its efficiency through intranasal delivery.Methods: The EFV (EME) was formulated by aqueous titration method. formulation screened globule size, zeta potential encapsulation efficiency. Bio-distribution performed gamma...
Abstract The present manuscript deals with experimental infections of bonnet macaques ( Macaca radiata ) to study disease progression for better insights into the Kyasanur Forest Disease (KFD) pathogenesis and transmission. Experimentally, 10 monkeys were inoculated KFD virus (KFDV) (high or low dose) regularly monitored sampled various body fluids tissues at preset time points. We found that only 2 out animals showed marked clinical signs becoming moribund, both in dose group, even though...
Abstract The availability of a safe and effective vaccine would be the eventual measure to deal with SARS-CoV-2 threat. Here, we have developed assessed immunogenicity protective efficacy an inactivated (BBV152) in hamsters. Three dose vaccination regime three formulations BBV152 induced significant titres specific IgG neutralizing antibodies. formulation imidazoquinoline adsorbed on alum adjuvant remarkably generated quick robust immune response. Th 1 biased response was demonstrated by...
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Delta variant has evolved to become the dominant SARS-CoV-2 lineage with multiple sub-lineages and there are also reports of re-infections caused by this variant. We studied disease characteristics induced AY.1 compared it B.1 variants in Syrian hamsters. assessed potential re-infection these Coronavirus 2019 recovered hamsters 3 months after initial infection. produced characterized high viral load respiratory tract...
Mycoplasma capricolum subspecies capripneumoniae (Mccp) causes contagious caprine pleuropneumonia (CCPP), a serious, economically important, WOAH (World Organisation for Animal Health) listed, acute, and highly respiratory disease, in goats. Despite, the presence of CCPP has been previously reported India, current study confirms disease state Maharashtra, India. Clinical signs like fever, lethargy, anorexia, nasal discharge, coughing distress followed by death (within 3–7 days if illness)...
Diabetes is one of the major risk factors for Alzheimer's disease (AD) development. The role elevated levels glucose, methylglyoxal (MGO), and advanced glycation end products (AGEs) in pathogenesis AD not well understood. In this pursuit, we studied rat models. plus-maze (EPM) behavioral study indicated that MGO induces anxiety. Treatment telmisartan (RAGE expression inhibitor) aminoguanidine (MGO quencher) attenuated induced Further, hippocampal proteomics demonstrated treated rats...
Objectives: The emergence of SARS-CoV-2 lineage B.1.617 variants in India has been associated with a surge the number daily infections. We investigated pathogenic potential Kappa (B.1.617.1) variant Syrian golden hamsters. Methods: Two groups hamsters (18 each) were inoculated intranasally isolates, B.1 (D614G) and variant, respectively. animals monitored for clinical signs body weight. Throat swab, nasal wash, organ samples (lungs, turbinate, trachea) collected screened using...
Ayurveda is one of the oldest systems traditional medicine that provides treatments for a wide range acute and chronic health problems. It common myth amongst people Ayurvedic drugs have no side effects, whereas fact these can cause adverse effects. Despite their use, safety data many formulations are still unavailable. Tapyadi loha an formulation traditionally claimed iron deficiency anemia in pregnant non-pregnant patients. However, scientific study has been conducted to evaluate its oral...
An experiment was conducted to evaluate the effect of Short Periods Incubation During Egg Storage (SPIDES) on hatchability broiler breeder eggs. Broiler hatching eggs (500) were divided into five groups (A E) containing 100 in each and further subdivided replicates 20 each. These subjected SPIDES treatment at temperature 37.50C 55-60% relative humidity (RH) viz. control A (7 days egg storage without incubated 8th day), B (10 with 1 h 5th day 11th C 2 D (15 10th 16th E day). All stored...
The objective of this study was to understand natural disease progression in infant CD1 mice after the bite Aedes aegypti mosquitoes infected by Zika virus (ZIKV, MR-766 strain).A. were experimentally with ZIKV strain via oral feeding route. Infected allowed feed on mice. Sick euthanized, and their organs collected subjected real-time RT-PCR, histo-pathology, immunohistochemistry.Clinical symptoms appeared 4-5 days being bitten mosquitoes, following which they euthanized. Real-time RT-PCR...
Abstract SARS-CoV-2 Omicron variant is rampantly spreading across the globe. Animal models are useful in understanding disease characteristics as well properties of emerging variants. We assessed pathogenicity and immune response generated by BA.1 sub-lineage with R346K mutation 5 to 6-week old Syrian hamsters. Virus shedding, organ viral load, lung were sequentially assessed. The found be similar that other variants concerns hamsters like high replication respiratory tract interstitial...
An experiment was conducted to study the protective role of herb Emblica officinalis in induced aflatoxicosis broilers. Thirty day old broiler chicks divided into three groups. Birds group T0 were fed with standard basal rations. Group T1 birds feed mixed aflatoxin (AF) B1@150 ppb and T2 mix AFB1@150 E. @5 g/kg feed. Skin thicknesses measured six from each on 21st for cell mediated immune response. showed significant differences weight gain reduction response noted as compared group. Gross...