A5065101263- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Virology and Viral Diseases
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Bacillus and Francisella bacterial research
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Rabies epidemiology and control
- vaccines and immunoinformatics approaches
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Vector-borne infectious diseases
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- COVID-19 diagnosis using AI
- Antifungal resistance and susceptibility
- Viral Infections and Outbreaks Research
- Immunotherapy and Immune Responses
- Retinal and Optic Conditions
- Microbial infections and disease research
ICMR-National Institute of Virology
2018-2025
Indian Council of Medical Research
2019-2021
Government College Kodanchery
2019
Government Medical College
2019
Abstract The drastic rise in the number of cases Maharashtra, India has created a matter concern for public health experts. Twelve isolates VUI lineage B.1.617 were propagated VeroCCL81 cells and characterized. Convalescent sera COVID-19 recipients BBV152 (Covaxin) able to neutralize B.1.617.
SARS-CoV-2 variant of concern mainly Delta and Beta is global public health due to its impact on existing vaccines. Here, we assessed the neutralization sera from COVID-19 recovered cases BBV152 vaccinees against variants. vaccine found confer significant protection both
From March to June 2021, India experienced a deadly second wave of COVID-19, with an increased number post-vaccination breakthrough infections reported across the country. To understand possible reason for these breakthroughs, we collected 677 clinical samples (throat swab/nasal swabs) individuals from 17 states/Union Territories country who had received two doses (n = 592) and one dose 85) vaccines tested positive COVID-19. These cases were telephonically interviewed data analyzed. A total...
We retrieved Nipah virus (NiV) sequences from 4 human and 3 fruit bat (Pteropus medius) samples a 2018 outbreak in Kerala, India. Phylogenetic analysis demonstrated that NiV humans was 96.15% similar to Bangladesh strain but 99.7%-100% Pteropus spp. bats, indicating bats were the source of outbreak.
We report here a Nipah virus (NiV) outbreak in Kozhikode district of Kerala state, India, which had caused fatal encephalitis 12-year-old boy and the response, led to successful containment disease related investigations. Quantitative real-time reverse transcription (RT)-PCR, ELISA-based antibody detection, whole genome sequencing (WGS) were performed confirm NiV infection. Contacts index case traced isolated based on risk categorization. Bats from areas near epicenter sampled for throat...
Abstract We performed the plaque reduction neutralization test (PRNT 50 ) using sera collected from recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable activity vaccinated individuals showed UK-variant heterologous strain with similar efficiency, dispel uncertainty possible escape.
Abstract India experienced its sixth Nipah virus (NiV) outbreak in September 2023 the Kozhikode district of Kerala state. The NiV is primarily transmitted by spillover events from infected bats followed human‐to‐human transmission. clinical specimens were screened using real‐time RT‐PCR, and positive further characterized next‐generation sequencing. We describe here an in‐depth presentation management NiV‐confirmed cases containment activities. current reported a total six with two deaths,...
We have isolated the new severe acute respiratory syndrome coronavirus-2 variant of concern 202 012/01 from positive coronavirus disease 2019 cases that travelled UK to India in month December 2020. This emphasizes need for strengthened surveillance system limit local transmission this variant.
The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution virus clades and variants circulating different parts India between January August 2020. NPS/OPS from representative positive states union territories were collected every month through VRDLs country analyzed using next-generation sequencing. Epidemiological analysis 689 SARS-CoV-2 clinical samples revealed GH GR to be predominant northern...
India introduced BBV152/Covaxin and AZD1222/Covishield vaccines in January 2021. We estimated the effectiveness of these against severe COVID-19 among individuals aged ≥45 years.We did a multi-centric, hospital-based, case-control study between May July Cases were patients, controls negative from 11 hospitals. Vaccine (VE) was for complete (2 doses ≥ 14 days) partial (1 dose 21 vaccination; interval two vaccine vaccination Delta variant. used random effects logistic regression model to...
The apprehension of needles related to injection site pain, risk transmitting bloodborne pathogens, and effective mass immunization have led the development a needle-free system (NFIS). Here, we evaluated efficacy NFIS needle (NIS) for delivery immunogenicity DNA vaccine candidate ZyCoV-D in rhesus macaques against SARS-CoV-2 infection. Briefly, 20 were divided into 5 groups (4 animals each), that is, I (1 mg dose by NIS), II (2 III NFIS), IV NFIS) V (phosphate-buffer saline [PBS])....
Since 2018, the Indian state of Kerala has reported four Nipah virus (NiV) disease outbreaks, raising concerns about NiV spillover from bats to human population. Considering this, a cross-sectional study was undertaken in
Abstract Recently, multiple SARS-CoV-2 variants have been detected across the globe. The recent emergence of B.1.617 lineage has created serious public health problem in India. high transmissibility was observed with this which led to daily increase number infections. Apparently, sub-lineage B.1.617.2 slowly dominated other including B1617.1, B.617.3 and B.1.1.7. With this, World Health Organization described as variant concern. Besides concern B.1.351 also reported from India, known...
Abstract Background In June 2019, Nipah virus (NiV) infection was detected in a 21-year-old male (index case) of Ernakulum, Kerala, India. This study undertaken to determine if NiV circulation Pteropus species ( spp) those areas where the index case had visit history 1 month. Methods Specialized techniques were used trap medius bats (random sampling) vicinity area. Throat and rectal swabs samples 141 along with visceral organs 92 collected detect presence by real-time reverse...
The study demonstrated that the breakthrough cases and COVID-19 recovered individuals with one or two doses of Covishield™ vaccine had relatively higher neutralizing responses against Delta variant in comparison to participants who were administered either Covishield™.
Background During the second wave of COVID-19 pandemic, outbreaks Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue Chikungunya negative samples retrospectively screened to determine presence virus different geographical regions India. Methods May October 2021, clinical 1475 patients, across 13 states a union territory re-tested for Dengue, by CDC Trioplex Real time RT-PCR. rRTPCR positive further with anti-Zika IgM Plaque Reduction Neutralization...
Outbreaks of HFMD in children aged <5 years have been reported worldwide and the major causative agents are Coxsackievirus (CV) A16, enterovirus (EV)-A71 recently CVA6. In India, is a disease that not commonly reported. The purpose study was to identify type(s) associated with large outbreak Hand, foot, mouth during COVID-19 pandemic 2022. Four hundred twenty five clinical samples from 196-suspected cases were collected different parts country. This finding indicated emergence CVA6 along...
Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to Western Ghats region Karnataka state in India. Over years, there have been reports its spread newer areas within and outside Karnataka. The absence an effective treatment for mandates need further research development novel vaccines. present study designed develop a multi-epitope vaccine candidate against KFDV using immunoinformatics approaches. A total 74...
Abstract Covishield comprises the larger proportion in vaccination program India. Hence, it is of utmost importance to understand neutralizing capability vaccine against B.1.617.1 variant which considered responsible for surge cases The neutralizing-antibody (NAb) titer B.1.167.1 and prototype B.1 (D614G) was determined sera (4 weeks after second dose) COVID-19 naïve subjects (n=43) recovered (n=18). results demonstrated that (n=18) who received two doses have higher NAb response compared...