A5010951828- COVID-19 epidemiological studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Pandemic Impacts
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Amoebic Infections and Treatments
- Streptococcal Infections and Treatments
- Advanced Drug Delivery Systems
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Antimicrobial agents and applications
- Synthesis and biological activity
- Infection Control and Ventilation
- Urinary Tract Infections Management
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Advancements in Transdermal Drug Delivery
- Bacterial biofilms and quorum sensing
- Viral Infections and Outbreaks Research
- Plant Pathogenic Bacteria Studies
- Drug Solubulity and Delivery Systems
- SARS-CoV-2 detection and testing
- Actinomycetales infections and treatment
- Synthesis of heterocyclic compounds
Jamia Hamdard
2013-2024
Institute of Medical Sciences
2013-2024
Universal College
2009
College of Medical Sciences
2009
Universal College of Medical Sciences
2009
Background: Methicillin resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community infections. Its prevalence varies with country hospitals within country. The current study estimates the MRSA strains investigates their antibiogram in western Nepal. Methodology: A total 162 S. were isolated from various clinical specimens, antibiotic susceptibility tests performed using disc diffusion, growth on oxacillin screen agar, minimum inhibitory concentration (MIC). Results:...
India introduced BBV152/Covaxin and AZD1222/Covishield vaccines in January 2021. We estimated the effectiveness of these against severe COVID-19 among individuals aged ≥45 years.We did a multi-centric, hospital-based, case-control study between May July Cases were patients, controls negative from 11 hospitals. Vaccine (VE) was for complete (2 doses ≥ 14 days) partial (1 dose 21 vaccination; interval two vaccine vaccination Delta variant. used random effects logistic regression model to...
Aeromonas salmonicida belonging to the genus Aeromonas, is a common pathogen that causes furunculosis and septicaemia in variety of fishes. It infects cold blooded vertebrates living at low temperatures mainly salmonid fish hence named salmonicida. Untill recently Aeromanas considered be pathogen. A. non-pathogenic for humans as it cannot grow 37ºC. "However, In our laboratory culture plates broths were incubated twice 37ºC each time same type colonies isolated which identified samonicida by...
S.paucimobilis has a diverse nutritional substrate spectrum and found in both environmental hospital settings. Sphingomonas paucimobilis is rarely isolated from clinical specimen. This low virulence organism since been reported to cause variety of diseases 1979. It be associated with community acquired nosocomial including bacteremia, catheter related sepsis, diarrhoeal diseases, peritonitis, meningitis, cutaneous infections, endopthalmitis, visceral infections , urinary tract etc. We report...
Candidal vulvovaginitis involving multispecies of Candida and epithelium-bound biofilm poses a drug-resistant pharmacotherapeutic challenge. The present study aims for disease-specific predominant causative organism resolution the development tailored vaginal drug delivery system. proposed work fabricates luliconazole-loaded nanostructured lipid carrier-based transvaginal gel combating albicans disease amelioration. interaction binding affinity luliconazole against proteins C. were assessed...
The aim of this study was to observe the secondary infection rate and transmission dynamics COVID-19 among household contacts, their associations with various factors across four dimensions interaction.This a case-ascertained unvaccinated contacts laboratory-confirmed case in New Delhi between December 2020 July 2021. For study, 99 index cases 316 were interviewed sampled (blood oro-nasal swab) on days 1, 7, 14, 28.The 44.6% (95% confidence interval (CI) 39.1-50.1). predictors individual...
Nocardiosis is a rare but well-established opportunistic infection. We are presenting two cases of diagnosed in the microbiology laboratory, one an immuno-competent elderly patient and other immunocompromised with AIDS. The first case was pulmonary which caused by Nocardia asteroides complex concomitant infections Staphylococcus aureus Blastoschizomyces capitatus. In second case, brasiliensis isolated from pus extracted HIV positive patient, lymphoadenopathy neck, at upper right clavicular...
Abstract Microscopy-based tuberculosis (TB) diagnosis i.e. Ziehl-Neelsen screening still remains the primary diagnostic method in resource poor and high TB burden countries, however this has sensitivity (~60%). Bringing three million patients who are left undiagnosed under treatment been a major focus as part of END-TB strategy across world. We have developed portable set-up called ‘SeeTB’ that converts bright-field microscope into fluorescence (FM) with minimal interventions. SeeTB, total...
Abstract Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions human subjects. Microbial causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) poly(meth) methacrylate (PMMA) employing electrospinning method form PVA:PMMA:CPX...
Purpose: Enterococci express high degree of resistance towards wide range antibiotics. Production biofilm and many virulence factors along with drug makes it difficult to eradicate the infection from urinary tract. The present study detected expression such including production by multidrug-resistant (MDR) enterococci. Materials Methods: Drug susceptibility 103 uropathogenic enterococci was performed followed estimation minimum inhibitory concentration high-level gentamicin vancomycin...
A ciprofloxacin-loaded water-in-oil nanoemulsion (CPX-NE) was prepared and evaluated for the antimicrobial effect against oral biofilms produced by Enterococcus faecalis. CPX-NE ultrasonication using functional excipients oleic acid (oil phase), Span 80 (surfactant), Transcutol P (cosurfactant). Rheological parameters (viscosity = 20 ± 1.24 cp) confirmed optimum values CPX-NE, a pH of 6.5 0.23 suggested simulation with mouth cavity, refractive index (1.46 0.22), % transmittance (92.34 0.02)...
Reliable, fast, and affordable diagnosis for tuberculosis (TB) remains a challenge to reduce disease incidence in resource-poor countries. Tests based on nucleotide sequences that are signature Mycobacterium have the potential make positive impact case detection rates, which can eventually help control TB. Using extensive comparative bioinformatics approach, we mined genome M. tuberculosis-specific genes identified four so-called sequence (SS). With <25% homology with other known...
Background: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines from January 2021. We estimated effectiveness of these against severe Coronavirus disease 2019 (COVID-19) among individuals aged >=45 years.Methods: did a multi-centric, hospital-based, case–control study between May July Cases were COVID-19 patients controls negative 11 hospitals. Vaccine (VE) was for full (2 doses ≥14days) partial (1 dose ≥21 days) vaccination; duration two vaccine the Delta variant. used random...
The transmission of respiratory pathogens, including SARS-CoV-2, is often facilitated through household contact. To better understand the rate COVID-19 among households and factors that affect viral clearance seroconversion, a case-ascertained community-based prospective study was conducted between December 2020 June 2021 on urban population national capital region India. collected nasopharyngeal swabs for SARS-CoV-2 RT-PCR 1st, 7th, 14th, 28th day, blood samples antibody detection day from...
Abstract The current investigation describes the synthesis of 1,3,4‐oxadiazole benzimidazole hybrids 5 (a–m) as antibacterial agents against methicillin‐resistant Staphylococcus aureus (MRSA) by targeting enoyl‐acyl carrier protein binding site reductase (FabI). Compounds having better (2–6 µg/mL) minimum inhibitory concentrations (MIC) than ampicillin (100 in initial screening using broth dilution method S. ( ATCC ‐29213) were further gauged for their antimicrobial potential MRSA (ATCC...
Abstract Background: A number of laboratory-based diagnostic modules are available for the diagnosis extrapulmonary tuberculosis (EPTB), which vary greatly in terms sensitivity and specificity. Methods: In this cross-sectional study, we conducted a comparative evaluation efficacy Xpert MTB/RIF testing conventional techniques clinically suspected cases EPTB. Various samples submitted at tertiary care hospital Northern India were subjected to Ziehl–Neelsen (ZN) staining, fluorescent...
Background: Enterococci causes serious infection due to its higher ability colonize and increasing resistance various drugs. Mutation plasmid mediated genetic exchange are the main reason for high rate of acquisition antibiotic resistance. The study was aimed determine profile enterococcal isolates from clinical samples detect presence aac (6′) Ie-aph (2″) Ia gene in which show phenotypic level gentamicin resistance.Methods:Clinical a tertiary care hospital southern Delhi were subjected...
Enterococci are known to cause life-threatening infections which difficult treat as the organism harbors innate resistance many antibiotics and can amass toward others through plasmid-mediated genetic exchange.The study evaluates drug susceptibility profile of various Enterococcus species isolated from patient specimens submitted for bacteriological analysis check incidence aac(6') Ie-aph(2") Ia gene.This in vitro cross-sectional was executed at bacteriology laboratory a 470 bedded hospital...