A5035302046- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- HIV/AIDS drug development and treatment
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- interferon and immune responses
- Malaria Research and Control
- Hepatitis B Virus Studies
- Rabies epidemiology and control
- COVID-19 epidemiological studies
- Machine Learning in Bioinformatics
- vaccines and immunoinformatics approaches
- CRISPR and Genetic Engineering
- COVID-19 diagnosis using AI
Government Medical College
2021-2022
Government College Kodanchery
2021
Institute of Genomics and Integrative Biology
2021
Georgetown University
2008-2017
Georgetown University Medical Center
2008-2017
Hospital Clínic de Barcelona
2011
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2011
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2011
We report here a Nipah virus (NiV) outbreak in Kozhikode district of Kerala state, India, which had caused fatal encephalitis 12-year-old boy and the response, led to successful containment disease related investigations. Quantitative real-time reverse transcription (RT)-PCR, ELISA-based antibody detection, whole genome sequencing (WGS) were performed confirm NiV infection. Contacts index case traced isolated based on risk categorization. Bats from areas near epicenter sampled for throat...
West Nile virus and dengue are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics currently available. These viruses encode serine protease is essential for polyprotein processing, required step in the viral replication cycle. In this study, high-throughput screening assay was employed to screen approximately 32,000 small-molecule compounds identification inhibitors. Lead inhibitor with three distinct core chemical structures...
Coronavirus disease 2019 (COVID-19) rapidly spread from a city in China to almost every country the world, affecting millions of individuals. The rapid increase COVID-19 cases state Kerala India has necessitated understanding SARS-CoV-2 genetic epidemiology. We sequenced 200 samples patients using COVIDSeq protocol amplicon-based sequencing. analysis identified 166 high-quality single-nucleotide variants encompassing four novel and 89 new Indian isolated SARS-CoV-2. Phylogenetic haplotype...
ABSTRACT Noroviruses (NoV) are members of the family Caliciviridae . The human NoV open reading frame 1 (ORF1) encodes a 200-kDa polyprotein which is cleaved by viral 20-kDa 3C-like protease (Pro, NS6) into 6 nonstructural proteins that necessary for replication. ORF1 processed in specific order, with “early” sites (NS1/2-3 and NS3-4) being rapidly three “late” (NS4-5, NS5-6, NS6-7) subsequently less efficiently. Previously, we demonstrated processing order directly correlated efficiency...
ABSTRACT Coronavirus disease 2019 (COVID-19) rapidly spread from a city in China to almost every country the world, affecting millions of individuals. Genomic approaches have been extensively used understand evolution and epidemiology SARS-CoV-2 across world. Kerala is unique state India well connected with rest world through large number expatriates, trade, tourism. The first case COVID-19 was reported January 2020, during initial days pandemic. rapid increase cases has necessitated...
Specific sequence changes in codons 70 and 91 of the hepatitis C virus genotype 1b (HCV GT1b) core gene have been associated with increased risk hepatocellular carcinoma (HCC). Essentially all previous studies were conducted Asian populations a wide range liver disease, none specifically GT1a-infected individuals. We pilot study multiethnic population USA HCV-related cirrhosis to determine if this association extended individuals other HCV HCC risk. sequences from sera 90 GT1 carriers (42...
We describe genomic analysis of SARS-CoV-2 isolates from breakthrough infections in six healthcare workers following vaccination with AZD1222/Covishield. Four patients were infected by the variant concern B.1.1.7 while other possessed E484K and S477N mutations spike protein associated immune escape.
Next Generation Sequencing (NGS) is the gold standard for detection of new variants SARS-CoV-2 including those which have immune escape properties, high infectivity, and variable severity. This test helpful in genomic surveillance, planning appropriate timely public health interventions. But labs with NGS facilities are not available small or medium research settings due to cost setting up such a facility. Transportation samples from many places few centers testing also produces delays...
The SARS-CoV-2 Variant of Concern, Delta (B.1.617.2) was first reported in December 2020 India and has spread colossally throughout the globe. Owing to factors like increased transmissibility, immune escape, virulence, delta variant been considered as a potential public health threat apart from other variants concern alpha, beta gamma. Kerala one states enroll systematic genomic surveillance. In present report, vaccine breakthrough infections were followed up 147 patients including 55...