A5021298640- Cardiac electrophysiology and arrhythmias
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Genomic variations and chromosomal abnormalities
- Nanoparticles: synthesis and applications
- Genetic Associations and Epidemiology
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Microbial Metabolism and Applications
- Immune responses and vaccinations
- melanin and skin pigmentation
- Pharmacogenetics and Drug Metabolism
- Food Industry and Aquatic Biology
- Healthcare cost, quality, practices
- Botulinum Toxin and Related Neurological Disorders
- Berberine and alkaloids research
- Microbial Metabolites in Food Biotechnology
- Genetics, Bioinformatics, and Biomedical Research
- Neonatal and fetal brain pathology
- Primary Care and Health Outcomes
- Inflammasome and immune disorders
Institute of Genomics and Integrative Biology
2020-2024
Government of Himachal Pradesh
2023-2024
Shoolini University
2023
Academy of Scientific and Innovative Research
2020-2022
Gian Sagar Medical College and Hospital
2014
Advanced Dermatology
1984
With the advent of next-generation sequencing, large-scale initiatives for mining whole genomes and exomes have been employed to better understand global or population-level genetic architecture. India encompasses more than 17% world population with extensive diversity, but is under-represented in sequencing datasets. This gave us impetus perform analyze genome 1029 healthy Indian individuals under pilot phase 'IndiGen' program. We generated a compendium 55,898,122 single allelic variants...
Abstract Emerging reports of SARS‐CoV‐2 breakthrough infections entail methodical genomic surveillance for determining the efficacy vaccines. This study elaborates analysis isolates from following vaccination with AZD1222/Covishield and BBV152/Covaxin. Variants concern B.1.617.2 B.1.1.7 responsible cases surge in April–May 2021 Delhi, were predominant lineages among infections.
Emerging reports of SARS-CoV-2 breakthrough infections entail methodical genomic surveillance for determining efficacy vaccines. This study elaborates analysis isolates from following vaccination with AZD1222/Covishield and BBV152/Covaxin.Variants concern B.1.617.2 B.1.1.7 responsible cases surge in April-May 2021 Delhi, were the predominant lineages among infections.
Skin conditions form a major bulk of diseases in the community. With disproportionately low number dermatologists country, and greatly unequal distribution between urban versus rural areas, ineffective treatment mismanagement skin are, however, commonplace.
Reticulate acropigmentation of Kitamura has been described in 8 subjects belonging to two unrelated families. All the patients were found be affected their second decade.
Nanoparticles (NPs) have uniform chemical composition, size, and morphology. Microorganisms are of great interest in Nanoparticle synthesis. The green production nanomaterials occurs either intracellularly or extracellularly. Gold silver nanoparticles mostly synthesised by the enzymatic degradation metal ions. produced NPs characterized different instruments such as ultraviolet visible, dynamic light scattering, x-ray diffraction, scanning electron microscope, transmission etc. Our review...
Primary healthcare caters to nearly 70% of the population in India and provides treatment for approximately 80-90% common conditions. To achieve universal health coverage (UHC), Indian system is gearing up by initiating several schemes such as National Health Protection Scheme, Ayushman Bharat, Nutrition Supplementation Schemes, Inderdhanush Schemes. The delivery facing challenges irrational use medicines, over- under-diagnosis, high out-of-pocket expenditure, lack targeted attention...
Aim: Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence the drug safety/efficacy in patients across diverse ethnic populations. Materials & methods: We analyzed whole genomes of 1029 Indian individuals (IndiGen) to understand extent drug–gene (pharmacogenetic), drug–drugand drug–drug–gene interactions ;associated with therapy population. Results: identified 30 clinically significant pharmacogenetic variants and 73 predicted deleterious variants....
We describe genomic analysis of SARS-CoV-2 isolates from breakthrough infections in six healthcare workers following vaccination with AZD1222/Covishield. Four patients were infected by the variant concern B.1.1.7 while other possessed E484K and S477N mutations spike protein associated immune escape.
Abstract Background The prevalence and genetic spectrum of cardiac channelopathies exhibit population-specific differences. We aimed to understand the channelopathy-associated variations in India, which is characterised by a genetically diverse population largely understudied context these disorders. Results utilised IndiGenomes dataset comprising 1029 whole genomes from self-declared healthy individuals as template filter variants 36 genes known cause channelopathies. Our analysis revealed...
BackgroundStandard treatment workflows (STWs) indeed play a crucial role in enhancing healthcare delivery by providing structured guidelines for managing prevalent diseases. These are particularly beneficial primary and secondary settings, where they help standardize protocols, streamline referrals, ultimately improve efficiency.MethodsIndian Council of Medical Research, collaboration with the National Health Authority World Organisation India country office developed STWs. The broad medical...
Cerebral palsy (CP) is caused by static lesion to a developing nervous system that primarily affects motor function.Spastic involvement characteristic of most these individual.Dynamicequinus common deformity worsens the ambulatory ability both diplegic and hemiplegic conditions.The use electromyographic (EMG) biofeedback has been suggested as training tool improve increase activation weak partially paralyzed muscles decrease affected spasm or spasticity without regard specific...
Nanoparticles (NPs) have uniform chemical composition, size, and morphology. Microorganisms are of great interest in Nanoparticle synthesis. The green production nanomaterials occurs either intracellularly or extracellularly. Gold silver nanoparticles mostly synthesized by the enzymatic degradation metal ions. produced NPs characterized different instruments such as ultraviolet visible, dynamic light scattering, x-ray diffraction, scanning electron microscope, transmission etc. Our review...
Reinfections due to SARS-CoV-2 have been reported from several countries. Repeat positive RT-PCR reports of COVID-19 could be attributed reinfections or reactivations. Several studies repeat positives. Our study discusses a case series patients with chronic immunosuppressive illness, who had for COVID-19, detected as reinfection and reactivation on whole-genome sequencing.