A5064592126- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Pharmacogenetics and Drug Metabolism
- Folate and B Vitamins Research
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Ferroptosis and cancer prognosis
- Porphyrin Metabolism and Disorders
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Berberine and alkaloids research
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Intestinal Malrotation and Obstruction Disorders
- Inflammasome and immune disorders
- interferon and immune responses
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Cholesterol and Lipid Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
St. John's National Academy of Health Sciences
2020-2024
Institute of Genomics and Integrative Biology
2014-2024
Council of Scientific and Industrial Research
2018-2024
Academy of Scientific and Innovative Research
2016-2024
St.John's Medical College Hospital
2024
Georgia Institute of Technology
2013-2016
State Street (United States)
2015
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role a novel vascular endothelial-associated lncRNA (VEAL2) in regulating permeability. Precise editing veal2 loci zebrafish (veal2gib005Δ8/+ ) induced cranial hemorrhage. In vitro and vivo studies revealed that competes with diacylglycerol for interaction protein kinase C beta-b (Prkcbb) regulates its activity. Using PRKCB2 bait, identified functional ortholog humans from...
Introduction Genetic variants contribute to differential responses non-insulin antidiabetic drugs (NIADs), and consequently variable plasma glucose control. Optimal control of is paramount minimizing type 2 diabetes-related long-term complications. India’s distinct genetic architecture its exploding burden diabetes warrants a population-specific survey NIAD-associated pharmacogenetic (PGx) variants. The recent availability large-scale whole genomes from the Indian population provides unique...
The importance of vitamin B 12 (cobalamin) in numerous biological processes, including DNA synthesis and cellular energy production, underscores the need for therapeutic public health strategies to address insufficiency/deficiency population. Genetic variations pathways influencing cobalamin absorption, transport, metabolism can affect various direct indirect measures status. To facilitate a structured approach studying these genetic factors, we aimed systematically curate create...
Whole genome sequencing is poised to revolutionize personalized medicine, providing the capacity classify individuals into risk categories for a wide range of diseases. Here we begin explore how whole (WGS) might be incorporated alongside traditional clinical evaluation as part preventive medicine. The present study illustrates novel approaches integrating genotypic and information assessment generalized health risks assist in promotion wellness maintenance good health.Whole sequences...
Liver plays a key role in maintaining glucose homeostasis and impaired hepatic metabolism is associated with type 2 diabetes. In the present study, we used RNA sequencing to profile transcriptome of livers diabetic db/db mice as compared normal db/+ identified 218 differentially expressed genes. Amongst these, there were 3 lncRNAs that significantly downregulated H19 was most altered lncRNA mice. expression correlated genes glycolysis gluconeogenesis pathways, which suggest levels can...
The organization of structure and function cardiac chambers in vertebrates is defined by chamber-specific distinct gene expression. This peculiarity uniqueness the genetic signatures demonstrates functional resolution attributed to different heart. Altered expression chamber genes can lead individual related dysfunctions disease patho-physiologies. Information on transcriptional repertoire compartments important understand spectrum specific anomalies. We have carried out a genome wide...
Ethnic differences in pharmacogenomic (PGx) variants have been well documented literature and could significantly impact variability response adverse events to therapeutics. India is a large country with diverse ethnic populations of distinct genetic architecture. India's national genome sequencing initiative (IndiGen) provides unique opportunity explore the landscape PGx using population-scale whole sequences. We analyzed IndiGen variation dataset (N = 1029 genomes) along global population...
Recent transcriptome annotation using deep sequencing approaches have annotated a large number of long non-coding RNAs in zebrafish, popular model organism for human diseases. These studies characterized lncRNAs critical developmental stages as well adult tissues. Each the has uncovered distinct set lncRNAs, with minor overlaps. The availability raw RNA-Seq datasets public domain encompassing time-points and tissues provides us unique opportunity to understand spatiotemporal expression...
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish ( Danio rerio ) for insertional mutagenesis. We identified three mutants where the GBT captured gene. One of adult viable had bradycardia (heart arrhythmia) enlarged chambers or hypertrophy; we named it “bigheart.” Bigheart mutant insertion maps grin2bb N-methyl D-aspartate...
South Asia is home to |$\sim $|20% of the world population and characterized by distinct ethnic, linguistic, cultural genetic lineages. Only limited representative samples from region have found its place in large population-scale international genome projects. The recent availability scale data multiple populations datasets Asian countries public domain motivated us integrate into a comprehensive resource. In present study, we integrated total six encompassing 1213 human exomes genomes...
Familial Mediterranean fever (FMF), an autosomal recessive and rare autoinflammatory disease is caused by genetic mutations in the MEFV gene highly prevalent basin. Although carrier frequency of specific variants has been reported from isolated studies, a comprehensive view region not possible due to paucity data. The recent availability whole-genome whole-exome datasets prompted us study epidemiology region. We assembled data 5 encompassing for 2115 individuals multiple subpopulations also...
Personalized medicine is predicated on the notion that individual biochemical and genomic profiles are relatively constant in times of good health to some extent predictive disease or therapeutic response. We report a pilot study quantifying gene expression methylation profile consistency over time, addressing reasons for uniqueness, its relation N = 1 phenotypes. Whole blood samples from four African American women, Caucasian men drawn Atlanta Center Health Discovery Well Being at three...
Pharmacogenetic landscapes of commonly used antiplatelet drugs, warfarin and clopidogrel have been studied in-depth in many countries. However, there is a paucity data to understand their patterns the Arab populations.We analyzed whole exome sequencing datasets 100 Qatar individuals available public domain with this perspective.We characterized allelic distribution variants routinely tested for clopidogrel. We additionally evaluated population stratification its effect on allele frequency...
The bioavailability of crystalline vitamin B
Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal profiles 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses conducted assess microbial functions related stunting, underweight wasting. The was enriched Prevotella 9, Bifidobacterium Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ)...
RNA is known to play diverse roles in gene regulation. The clues for this regulatory function of are embedded its ability fold into intricate secondary and tertiary structure. We report the transcriptome-wide structure zebrafish at single nucleotide resolution using Parallel Analysis Structure (PARS). This study provides map coding non-coding RNAs. pairing probabilities 54,083 distinct transcripts genome were documented. identified structural features functional units mRNAs. Translation...