A5021679174- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Traumatic Ocular and Foreign Body Injuries
- Cytomegalovirus and herpesvirus research
- Vascular Malformations Diagnosis and Treatment
- Ocular Oncology and Treatments
- Systemic Lupus Erythematosus Research
- Infectious Diseases and Tuberculosis
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Retinal Development and Disorders
- Toxoplasma gondii Research Studies
- Corneal surgery and disorders
- Gut microbiota and health
- Vasculitis and related conditions
- Child Abuse and Related Trauma
- Ocular Disorders and Treatments
- Complement system in diseases
- Rabies epidemiology and control
L V Prasad Eye Institute
2016-2025
Retina Institute
2024-2025
Collaborative Group (United States)
2024
Creative Commons
2021-2022
World Health Organization - India
2022
Christie's
2021
Advanced Centre for Treatment, Research and Education in Cancer
2021
Narayana Nethralaya
2021
Sankara Nethralaya
2016-2020
Vasan Eye Care Hospital
2020
Abstract Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut and DR. Using fecal samples of healthy controls (HC) people T2DM with/without DR, communities were analysed using 16S rRNA gene sequencing data QIIME R software. Dysbiosis the microbiomes, at phyla genera level, was observed DR compared to HC. People exhibited greater discrimination from...
Abstract The proof-of-concept, study to investigate the presence of microorganisms in presumed infectious endophthalmitis using Next generation sequencing (NGS) was carried out vitreous biopsies from 34 patients with endophthalmitis, and thirty undergoing surgery for non-infectious retinal disorders as controls. Following DNA extraction Qiagen mini kit PCR amplification V3–V4 regions bacterial 16S rRNA ITS 2 region fungus, they samples were sequenced on an Illumina HiSeq 2500 Machine. Paired...
Studies have documented dysbiosis in the gut mycobiome people with Type 2 diabetes mellitus (T2DM). However, it is not known whether of T2DM patients would be reflected diabetic retinopathy (DR) and if so, observed similar DR. Gut mycobiomes were generated from healthy controls (HC), DR through Illumina sequencing ITS2 region. Data analysed using QIIME R software. Dysbiotic changes compared to HC at phyla genera level. Mycobiomes HC, could discriminated by heat map analysis, Beta diversity...
The complement system plays a crucial role in retinal homeostasis. While the proteomic analysis of ocular tissues diabetic retinopathy (DR)has shown deposition proteinstheir exact pathogenesis DR is yet unclear. We performed detailed investigation on by evaluating levels major proteins including C3, C1q, C4b, Complement FactorB (CFB) and Factor H (CFH)and their activated fragments from both classical alternative pathways vitreous humor serum samples proliferative (PDR) patients controls....
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role a novel vascular endothelial-associated lncRNA (VEAL2) in regulating permeability. Precise editing veal2 loci zebrafish (veal2gib005Δ8/+ ) induced cranial hemorrhage. In vitro and vivo studies revealed that competes with diacylglycerol for interaction protein kinase C beta-b (Prkcbb) regulates its activity. Using PRKCB2 bait, identified functional ortholog humans from...
To evaluate the anatomical and visual outcomes of inverted flap technique peeling internal limiting membrane (ILM) versus standard ILM for macular holes basal diameter more than 800 μm.Patients with very large idiopathic μm in (ranging from 243 to 840 minimum diameter) were retrospectively included study. In Group A, 18 eyes patients underwent using technique. B, conventional peeling. The primary endpoint was rate hole closure at 6 months after surgery. secondary outcome measure change...
Purpose: In this study, the gut fungal microbiome of uveitis (UVT) patients was generated and compared with healthy controls (HC) to identify dysbiosis in UVT ascertain role disease pathology. Methods: present microbiomes were analyzed fecal samples HC (n = 24) 14) using high-throughput Illumina sequencing ITS2 region ribosomal RNA. QIIME R software used for data analysis. Results: The richness diversity significantly decreased HC. Our analyses showed enrichment several pathogenic fungi...
In Brief Purpose: To describe a technique of wide-angle viewing as an educational tool in scleral buckling for rhegmatogenous retinal detachment. Methods: Retrospective comparative study the reported was performed. Fourteen consecutive patients each who underwent Chandelier-assisted (CSB) or standard (SSB) using indirect ophthalmoscope were included. The primary outcome measure proportion eyes that had successful reattachment retina. Results: Mean eye baseline visual acuity 20/160 CSB group...
Aim: To evaluate clinical presentation, course and outcomes in patients without a history of penetrating ocular trauma who developed Sympathetic Ophthalmia (SO) following vitreoretinal surgeriesMethods: Retrospective review records all diagnosed treated as S.O was done . All cases previous were included analyzed with respect to presentations, anatomic visual outcomes.Results: 175 sympathetic ophthalmia till June 2017. 16 these had undergone pars plana vitrecomy (PPV) the past no prior...
Purpose: Infection by the SARS-CoV2 virus results in an immune dysregulated state which can predispose to reactivation of Herpes viruses. This report describes development Acute Retinal Necrosis (ARN) two patients who had recovered from infection.Methods: Observational consecutive presented with ARN after having SARS-CoV-2 infection.Results: Case 1 was a 5-year-old child extensive peripheral necrotizing retinitis. 2 61-year-old gentlemen bilateral retinal detachment sieve-like breaks and...
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, joint manifestations which result in diagnostic difficulty therapeutic challenge. Here, we present case young male diagnosed with osteoarticular cutaneous involvement from an early age his life. He suffered challenges for long time was hence inadequately treated. had minimal response to conventional DMARDs but showed excellent...
Established consensus is lacking for the management of chronic central serous chorioretinopathy (CSCR). The role anti-VEGF agents in treating CSCR absence choroidal neovascular membrane (CNVM) equivocal. We aim to study intravitreal brolucizumab treatment persistent macular fluid without CNVM. This a prospective randomized, placebo-controlled trial be conducted among 42 patients with (>3 months duration) intraretinal and/or subretinal fluid. Patients will randomized 1:1 ratio receive or oral...
To explore the utility of Posterior Hyaloid Adhesions (PHA) as an Optical Coherence Tomography (OCT) biomarker toxoplasma retinochoroiditi. A retrospective review OCT scans infective retinitis cases to evaluate presence PHA at time presentation. Ninety-seven eyes active retinochoroiditis and 125 other etiologies were included. feature was present in 70 (72%) toxoplasmosis group compared where it 32 (26%). Univariate analysis revealed that significantly more prevalent retinitis. Multivariate...
To evaluate the efficacy of intravitreal anti-vascular endothelial growth factor monotherapy in treatment naive subretinal neovascular membrane (SRNVM) secondary to macular telangiectasia (Mactel) Type 2.A retrospective chart review consecutive patients with SRNVM Mactel who were examined between January 2007 and April 2011 was performed. Eyes diabetic retinopathy, age-related degeneration, or any other pathology excluded. Demographic data, medical history, ocular history recorded. The mean...
Aims To characterise the vasculature of retina in patients with Best vitelliform dystrophy, including those choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate fluorescein (FA). Methods This prospective observational study included 19 eyes 10 disease. Using OCTA, all layers were qualitatively characterised for each eye. Patients CNV also underwent FA, areas measured by OCTA FA correlated. Results Retinal characteristics revealed 14 (74%)...
Intravitreal Ganciclovir has been one of the treatments choice for cytomegalovirus (CMV) retinitis and used extensively its treatment since 1987. It not shown to have any major adverse effects. There are no reports on retinal toxicity even after multiple, repeated injections. Herein, we report a rare case multiple intravitreal injections in patient CMV retinitis.
Purpose To investigate the immunopathogenesis of endophthalmitis, and determine if cytokine profiles could serve as biomarkers disease severity in infectious endophthalmitis. Materials methods Vitreous samples 46 patients clinically diagnosed endophthalmitis (of which 25 were culture positive) 20 non-infectious controls from with Retinal Detachment (RD) or diabetic retinopathy included study. The chemokine expression patterns 40 immune mediators including 6 antiinflammatory cytokines, 15...