A5057344129- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Spondyloarthritis Studies and Treatments
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Biomarkers in Disease Mechanisms
- Eosinophilic Disorders and Syndromes
- Osteomyelitis and Bone Disorders Research
- Vascular Malformations and Hemangiomas
- COVID-19 Impact on Reproduction
- Otitis Media and Relapsing Polychondritis
- Sarcoidosis and Beryllium Toxicity Research
- Biological Activity of Diterpenoids and Biflavonoids
- Peripheral Neuropathies and Disorders
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Nizam's Institute of Medical Sciences
2014-2024
National Institute of Medical Statistics
2022
Background: Systemic lupus erythematosus (SLE)-associated myelitis or (LM), one of the twelve neuropsychiatric (NPSLE) syndromes, is a rare but severe complication lupus. In this study, we observed clinical and imaging profiles LM patients to assess long-term outcomes. Methods: This was retrospective study; data with follow-up were extracted from registry in last 15 years (2007-2022). Clinically, they divided as grey matter (GMM) versus white (WMM). Disease activity assessed by SLE Activity...
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, joint manifestations which result in diagnostic difficulty therapeutic challenge. Here, we present case young male diagnosed with osteoarticular cutaneous involvement from an early age his life. He suffered challenges for long time was hence inadequately treated. had minimal response to conventional DMARDs but showed excellent...
Despite the widespread clinical use of MTX in PsA, data from published randomized controlled studies suggest limited efficacy. The objective present study was to document efficacy MTX.This an open-label, prospective patients satisfying ClASsification criteria for Psoriatic ARthritis (CASPAR) PsA who received doses ⩾15 mg/week throughout follow-up period 9 months. Disease activity assessed across various domains by tender and swollen joint count, physician patient global assessment, DAS-28...
Introduction: Neuro-Behçet's disease (NBD) is an uncommon presentation in Behçet's (BD) with severe course and worse prognosis.Both vascular NBD without the classical triad of BD a single patient rarely reported.Case Presentation: Here 48-year-old male had extensive aortic aneurysm eroding vertebra for which he was diagnosed as BD.Two years later, presented headache cerebrovascular accident, his brain imaging showed hyperintensity right thalamus, basal ganglia, temporal lobe, internal...
Abstract Objectives To investigate the differences in clinical presentation, disease activity, HLA-B27 positivity nr-axSpA and AS. Methods Prospective observational study conducted tertiary care centre from India. Total 125 consecutive patients with chronic low backache were screened,96 fulfilling ASAS criteria for axial SpA included grouped into radiographic (AS) (n = 55) non-radiographic (n = 41) SpA. Demographic, clinical, activity functional indices, ESR noted group. HLA B27 testing was...
Abstract Objectives The aim was to describe the clinical profile and outcomes in patients with antisynthetase syndrome (ASS) from a tertiary care centre. Methods data investigations of all classified as ASS by Connors criteria over 5 years were recorded, they followed up prospectively. median (interquartile range) used for descriptive statistics. Clinical variables between Jo-1 non-Jo-1 groups without anti-Ro52 antibodies compared using χ2 test. Survival analysis done log rank Results 28 (23...
Objective Anti‐synthetase syndrome (ASSD) is a rare systemic autoimmune rheumatic disease (SARD) with significant heterogeneity and no shared classification criteria. We aimed to identify clinical serological features associated ASSD that may be suitable for inclusion in the data‐driven criteria ASSD. Methods utilized large, international, multi‐center “ Classification Criteria Syndrome ” (CLASS) project database, which includes both patients controls mimicking conditions, namely SARDs...
Background: Studies on antineutrophil cytoplasmic autoantibodies-associated vasculitis (AAV) from India are scarce. The aim of the present study was to characterize profile AAV and experience with rituximab in ocular granulomatous polyangiitis (GPA) our cohort. Methods: Clinical, laboratory, treatment details January 2010 May 2017 were noted. Continuous variables reported as mean standard deviation (SD). In GPA, clinical between survivors nonsurvivors compared using independent sample t...
Objective: The objective of this study is to measure plasma pentraxin 3 (PTX3) levels in Takayasu arteritis (TA) patients and compare the accuracy PTX3, high-sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR) distinguishing active disease from inactive disease. Methods: In a prospective, cross-sectional study, TA fulfilling 1990 American College Rheumatology criteria healthy controls were enrolled study. Indian Clinical Activity Score (ITAS 2010) ITAS ESR recorded....
Abstract Background/Aims IgG4-related sclerosing disease is a systemic characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs tumour-like involvement one or more exocrine glands other extranodal sites. The major involved are the salivary glands, lacrimal pancreas retroperitoneal space. Cardiac masses in IgG4 include hematoma, tumours, vegetations, calcific lesions rare conditions. tumours have variety benign malignant entities. We herein report...
Immunoglobulin G4-related disease (IgG4-RD) coexisting with clinically apparent autoimmune diseases, such as rheumatoid arthritis (RA) or antiphospholipid syndrome (APS), is a rarely documented combination in the scientific literature. In this case-based review, we present 2 intriguing cases preexisting namely, RA and primary APS, who exhibited coexistent IgG4- related lesions at unusual sites. The first case pertains to patient known presented an encasing mass esophagus leading stricture,...
<h3>Background</h3> In Takayasu arteritis (TA) Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are used to monitor disease activity. Thirty percent of patients with active inflammation have normal ESR while 40% without vascular elevated ESR.<sup>1</sup> Pentraxin 3 (PTX3) produced in wall during inflammation, may be a better biomarker <h3>Objectives</h3> To compare PTX3 levels TA healthy controls the accuracy high sensitive CRP (hs CRP) distinguishing from inactive disease....
Objectives Despite current advances in treatment, refractory lupus nephritis (RLN) continues to pose a challenge. The present paper studies the clinical profile and treatment outcomes patients with RLN. Methods This observational, bidirectional study enrolled consecutive (LN) from August 2018 January 2019, who either failed improve within three months, did not achieve partial renal response (PR) at six or complete (CR) after two years of treatment. Patients were followed every months;...
KEY MESSAGES1. Skin, joint involvement, and fever is the most common phenotype of MDA5 DM. 2. Cutaneous ulcers are very common.Myositis not uncommon, when present, severe in spite normal creatine phosphokinase (CPK).3. RPILD a predictor mortality.
Abstract Systemic lupus erythematous–associated pulmonary arterial hypertension (SLE-PAH) is one of the important causes mortality in patients. Different autoantibodies are associated with SLE-PAH which can predict its future development. The objective study was to identify distinct autoantibody-based clusters patients and compare demographic characters, clinical phenotypes, therapeutic strategy across clusters. Three autoantibody were identified using k-means cluster analysis 71 Cluster1...
Abstract Objectives Despite current advances in treatment, refractory lupus nephritis (RLN) continues to pose a challenge. The present paper studies the clinical profile and treatment outcomes patients with RLN. Methods This was an observational, bidirectional study enrolling consecutive of from August 2018 January 2019, who either failed improve within three months, did not achieve partial renal response (PR) at six or complete (CR) after two years treatment. Patients were followed every...
To investigate the in vitro antiradical and antioxidant properties of methanol extracts Garcinia lucida, Hymenocardia lyrata (H. lyrata) Acalypha racemosa.We determined activity total phenolic content, performed phytochemical screening from fruits, barks, leaves, roots stems these plants using standard procedures.The results showed that more than 60% DPPH., NO. HO. radicals were inhibited by extracts. The radical scavenging activity, capacity as well reducing power increased with...