Johannes Knitza
A5081745118- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Mobile Health and mHealth Applications
- Spondyloarthritis Studies and Treatments
- Musculoskeletal Disorders and Rehabilitation
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Social Media in Health Education
- Telemedicine and Telehealth Implementation
- Systemic Lupus Erythematosus Research
- Health Literacy and Information Accessibility
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Clinical Reasoning and Diagnostic Skills
- Chronic Disease Management Strategies
- Biosimilars and Bioanalytical Methods
- Psoriasis: Treatment and Pathogenesis
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Digital Mental Health Interventions
- Health and Medical Studies
- Chronic Lymphocytic Leukemia Research
Philipps University of Marburg
2023-2025
Université Grenoble Alpes
2020-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2018-2025
Universitätsklinikum Erlangen
2018-2025
Universitätsklinikum Gießen und Marburg
2023-2025
Universitätsklinikum Würzburg
2024
Center for Rheumatology
2024
Agence Régionale de Santé Ile-de-France
2023-2024
Policlinico San Matteo Fondazione
2024
Medizinische Hochschule Brandenburg Theodor Fontane
2024
Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these through deep depletion of B cells is a potential strategy achieving sustained drug-free remission.
Background Mobile health apps (MHA) have the potential to improve care. The commercial MHA market is rapidly growing, but content and quality of available are unknown. Instruments for assessment highly needed. Application Rating Scale (MARS) one most widely used tools evaluate MHA. Only few validation studies investigated its metric quality. No study has evaluated construct validity concurrent validity. Objective This evaluates validity, reliability, objectivity, MARS. Methods Data was...
Antisynthetase syndrome (ASSD) is a rare clinical condition that characterized by the occurrence of classic triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether presence ARS might affect presentation, evolution, outcome ASSD. In this study, we retrospectively recorded time onset, characteristics, clustering triad findings, survival...
Background Chronic rheumatic diseases need long-term treatment and professional supervision. Mobile apps promise to improve the lives of patients physicians. In routine practice, however, rheumatology are largely unknown little is known about their quality safety. Objective The aim this study was provide an overview mobile currently available in German app stores, evaluate using Application Rating Scale (MARS), compile brief, ready-to-use descriptions for rheumatologists. Methods App Store...
Mobile health (mHealth) defines the support and practice of care using mobile devices promises to improve current treatment situation patients with chronic diseases. Little is known about mHealth usage digital preferences rheumatic diseases.The aim study was explore usage, preferences, barriers, eHealth literacy reported by German diseases.Between December 2018 January 2019, (recruited consecutively) rheumatoid arthritis, psoriatic axial spondyloarthritis were asked complete a paper-based...
Abstract Pre-clinical studies suggest that large language models (i.e., ChatGPT) could be used in the diagnostic process to distinguish inflammatory rheumatic (IRD) from other diseases. We therefore aimed assess accuracy of ChatGPT-4 comparison rheumatologists. For analysis, data set Gräf et al. (2022) was used. Previous patient assessments were analyzed using and compared rheumatologists’ assessments. listed correct diagnosis comparable often rheumatologists as top 35% vs 39% ( p = 0.30);...
Objective To analyse the impact of COVID-19 pandemic on rheumatic patients’ and rheumatologists’ usage, preferences perception digital health applications (DHAs). Methods A web-based national survey was developed by Working Group Young Rheumatology German Society for League against Rheumatism. The prospective distributed via social media (Twitter, Instagram Facebook), QR code email. Descriptive statistics were calculated, regression analyses performed to show correlations. Results We...
Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection blood for the analysis inflammation markers autoantibodies could improve monitoring RA facilitate identification individuals at-risk RA.
Symptom checkers are increasingly used to assess new symptoms and navigate the health care system. The aim of this study was compare accuracy an artificial intelligence (AI)-based symptom checker (Ada) physicians regarding presence/absence inflammatory rheumatic disease (IRD). In survey study, German-speaking with prior rheumatology working experience were asked determine IRD suggest diagnoses for 20 different real-world patient vignettes, which included only basic symptom-related medical...
Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy manage pandemic. Although none of currently approved vaccines are live-attenuated, several reports disease flares, waning protection, acute-onset syndromes emerged as short-term adverse events after...
Abstract Introduction/Aims In this study we investigated COVID‐19 vaccination–related adverse events (ADEs) 7 days postvaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune disorders (SAIDs). Methods Seven‐day vaccine ADEs were collected an international patient self‐reported e‐survey. Descriptive statistics obtained multivariable regression was performed. Results Ten thousand nine hundred respondents analyzed (1227 IIM cases, 4640 SAID 5033...
Abstract Mobile health applications and digital therapeutics (DTx) aim to improve current patient care. Real-world data on DTx are, however, scarce. The of this study was evaluate the adherence, acceptance, efficacy in a clinical routine rheumatology setting. We conducted prospective observational cohort assessing use, DiGA ( Digitale Gesundheitsanwendungen ) by survey over 12 weeks. Patients included had have rheumatic disease been prescribed DiGA. Acceptance assessed using Net promoter...
Treat-to-target (T2T) is a main therapeutic strategy in rheumatology; however, patients and rheumatologists currently have little support making the best treatment decision. Clinical decision systems (CDSSs) could offer this support. The aim of study was to investigate accuracy, effectiveness, usability, acceptance such CDSS—Rheuma Care Manager (RCM)—including an artificial intelligence (AI)-powered flare risk prediction tool management rheumatoid arthritis (RA). Longitudinal clinical...
Abstract Purpose This study investigated the concordance of five different publicly available Large Language Models (LLM) with recommendations a multidisciplinary tumor board regarding treatment for complex breast cancer patient profiles. Methods Five LLM, including three versions ChatGPT (version 4 and 3.5, data access until September 3021 January 2022), Llama2, Bard were prompted to produce 20 LLM compared (gold standard), surgical, endocrine systemic treatment, radiotherapy, genetic...
Abstract Background Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, guide patients more effectively through health care system. Although SCs increasingly used, there exists little supporting evidence. Objective To assess diagnostic accuracy, patient-perceived usability, acceptance two SCs: (1) Ada (2) Rheport. Methods Patients newly presenting a...
The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution reducing poor clinical outcomes, vaccine hesitancy an obstacle achieving high levels uptake. This represents particular risk patients with autoimmune diseases, group already at increased hospitalization outcomes related infection. there is paucity long-term safety efficacy data in current evidence...
Objectives To test whether patients with immune-mediated inflammatory disease (IMIDs), who did not respond to two doses of the SARS-CoV-2 vaccine, develop protective immunity, if a third vaccine dose is administered. Methods Patients IMID failed seroconvert after were subjected vaccination either mRNA or vector-based vaccines. Anti-SARS-CoV-2 IgG, neutralising activity and T cell responses assessed at baseline 3 weeks revaccination also evaluated seprarately in rituximab (RTX) non-RTX...
Background The worldwide burden of musculoskeletal diseases is increasing. number newly registered rheumatologists has stagnated. Primary care, which takes up a key role in early detection rheumatic disease, working at full capacity. COVID-19 and its containment impede rheumatological treatment. Telemedicine rheumatology (telerheumatology) could support general practitioners. Objective goal this study was to investigate acceptance preferences related the use telerheumatology care among...