A5051482727- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Inflammation biomarkers and pathways
- Pregnancy and Medication Impact
- Rheumatoid Arthritis Research and Therapies
- Pregnancy and preeclampsia studies
- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Apelin-related biomedical research
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Gout, Hyperuricemia, Uric Acid
- Ocular Diseases and Behçet’s Syndrome
- IgG4-Related and Inflammatory Diseases
Rabin Medical Center
2015-2025
Tel Aviv University
2015-2025
Policlinico San Matteo Fondazione
2024
Ben-Gurion University of the Negev
2021
Soroka Medical Center
2021
Center for Rheumatology
2014
New York University
1994-1995
Columbia University Irving Medical Center
1994-1995
Weizmann Institute of Science
1993
Tel Aviv Sourasky Medical Center
1993
Since colchicine-sensitive microtubules regulate the expression and topography of surface glycoproteins on a variety cells, we sought evidence that colchicine interferes with neutrophil-endothelial interactions by altering number and/or distribution selectins endothelial cells neutrophils. Extremely low, prophylactic, concentrations (IC50 = 3 nM) eliminated E-selectin-mediated increment in adhesiveness for neutrophils response to IL-1 (P < 0.001) or TNF alpha changing distribution, but not...
Abstract Objective The Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes (TEMPO) is a 3‐year, double‐blind, multicenter study evaluating the efficacy safety etanercept, methotrexate, combination etanercept plus methotrexate in patients active rheumatoid arthritis (RA). results after 1 2 years have been previously reported. Here we provide 3‐year clinical radiographic outcomes RA. Methods In this randomized, TEMPO study, 682 received 25 mg twice weekly, ≤20 or...
Abstract Objective. To determine the value of measurement serum soluble tumor necrosis factor receptor (sTNFR), compared with established parameters such as anti–double‐stranded DNA, in monitoring systemic lupus erythematosus (SLE) disease activity, and to whether sTNFR are bioactive can effectively inhibit TNF bioactivity. Methods. Fifty‐three consecutive ambulatory or hospitalized SLE patients 140 healthy subjects were enrolled a prospective cohort study. Serum levels measured by unique...
To study the clinical spectrum of Behçet's disease (BD) in childhood, comparison to adult-onset disease.Nineteen children, who fulfilled criteria up age 16 yr, were studied. The results compared those 34 adult patients with BD. An activity index and severity score calculated for both groups.The mean onset was 6.9+/-3.9 similar ages found males females. childhood BD resembled that disease; however, prevalence certain manifestations different between children adults. Children had significantly...
Systemic lupus erythematosus-associated irreversible organ/system damage was previously associated with various clinical and demographic features. We analysed the Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) in a cohort 151 Israeli patients followed for mean (+/- s.d.) period 45.7 +/- 37.4 months. Mean score SLICC/ACR DI at first last encounters were 0.17 64 1.64 2.1, respectively (P < 0.0001). Multiple logistic regression analyses...
The aim of this study was to analyse pregestational and pregnancy risk factors for adverse fetal maternal outcome in lupus pregnancy. Twenty women with systemic erythematosus (SLE) (29 pregnancies) were prospectively evaluated. Mean patient age 29.5+/-4.7 years, mean disease duration, 6.3+/-6.5 years. Twenty-two pregnancies (75.9%) ended live births; preterm delivery occurred 17.4%, intrauterine growth restriction 50%, preeclampsia 3.7%, gestational hypertension 8%. Six (20.7%) spontaneous...
Abstract Background Mood disorders, such as anxiety and depression, are extremely prevalent among patients with rheumatoid arthritis (RA). In this study, we assessed the impact of treatment tocilizumab (TCZ), an IL‐6 antagonist, upon depressive symptoms in a cohort RA patients. Materials Methods Study participants were adults diagnosed who received weekly subcutaneous injection for 24 weeks. We used Hamilton Depression (HDRS) Anxiety (HAMA) scores order to assess severity depression anxiety,...
Abstract Objectives Autologous hematopoietic stem cell transplantation (AHSCT) has been shown to improve long-term survival for early diffuse progressive SSc compared with CYC. CYC, however, does not provide a benefit in SSc. The combination of MMF and rituximab is potent alternative regimen. We aimed retrospectively compare the outcomes patients who underwent AHSCT met eligibility criteria but received upfront therapy rituximab. Methods Repeated assessments modified Rodnan Skin Score...
Kidney function is not routinely assessed during pregnancy. Several studies have proposed antepartum kidney function, particularly 2nd trimester as a potential predictor of adverse pregnancy outcomes. It has been previously established that patients with Systemic Lupus Erythematosus are at increased risk for The association between and outcomes evaluated in diverse patient populations, among high obstetrical risk. In this observational study pregnant lupus North America Europe from...
To develop and evaluate the performance of multicriteria decision analysis (MCDA)-driven candidate classification criteria for antisynthetase syndrome (ASSD). A list variables associated with ASSD was developed using a systematic literature review then refined into an key domains by myositis interstitial lung disease (ILD) experts. This used to create preferences surveys in which experts were presented pairwise comparisons clinical vignettes asked select case that more likely represent ASSD....
Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event unknown. SLE has been associated with more than 100 autoantibody reactivities - anti-dsDNA prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of patients. We previously reported use antigen microarray characterize serology. now report results expanded study serology patients and scleroderma (SSc) compared healthy controls. The analysis validated...
This study aimed to determine the value of hypocomplementemia in predicting renal and patient survival patients with antineutrophil cytoplasmatic antibody-associated vasculitis (AAV).A retrospective analysis 30 consecutive who were diagnosed AAV followed at our hospital from 1996 2011 was performed. Renal outcome determined by Modification Diet Disease equation. measures included accrual chronic kidney disease (CKD) defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73...
Methotrexate (MTX) exerts an anti-inflammatory effect via its metabolite adenosine, which activates adenosine receptors. The A3 receptor (A3AR) was found to be highly expressed in inflammatory tissues and peripheral blood mononuclear cells (PBMCs) of rats with adjuvant-induced arthritis (AIA). CF101 (IB-MECA), A3AR agonist, previously inhibit the clinical pathological manifestations AIA. aim present study examine MTX on expression level efficacy combined treatment AIA rats. were treated MTX,...
Neutrophils express receptors for numerous phlogistons which, when occupied, trigger distinct signal-transduction pathways. Previous studies have shown that stimulation of neutrophils with chemoattractants induces shedding the adhesive molecule L-selectin and increased expression beta 2-integrin CD11b/CD18. We determined effect ligation classic, G-protein-linked chemoattractant [C5a, interleukin-8 (IL-8), formylmethionyl-leucylphenylalanine (FMLP) substance P], Fc portion IgG (Fc gamma...