A5004803983- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Liver Diseases and Immunity
- Psoriasis: Treatment and Pathogenesis
- Hepatitis C virus research
- Skin Diseases and Diabetes
- Spondyloarthritis Studies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis B Virus Studies
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Muscle Physiology and Disorders
- Peripheral Neuropathies and Disorders
- Parkinson's Disease and Spinal Disorders
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
IRCCS Humanitas Research Hospital
2015-2024
Humanitas University
2015-2023
Clinical Centre of Kragujevac
2023
Centar za Promociju Nauke
2021
Center for Rheumatology
2018
In this work, we aimed to establish a clinical target in the management of knee osteoarthritis (KOA) and propose good practice (GCP) statements for carrying out treat-to-target strategy.A steering committee seven experts had formulated provisional set recommendations that were exposed discussion modification technical expert panel (TEP) 25 multidisciplinary from Europe, North America, South America Asia. The level evidence strength each recommendation was discussed. TEP overarching...
The purpose of this study was to evaluate the efficacy and safety Moderna-1273 mRNA vaccine for SARS-CoV-2 in patients with immune-mediated diseases under different treatments. Anti-trimeric spike protein antibodies were tested 287 rheumatic or autoimmune (10% receiving mycophenolate mofetil, 15% low-dose glucocorticoids, 21% methotrexate, 58% biologic/targeted synthetic drugs) at baseline 219 (76%) 4 weeks after second dose. Family members caretakers enrolled as controls. neutralizing serum...
Abstract The identification of anti-NXP2 antibodies is considered a serological marker dermatomyositis (DM), with calcinosis, severe myositis and, in some reports, cancer. Historically, these associations have been detected by immunoprecipitation (IP), but the last few years commercial immunoblotting assays released. aim this collaborative project was to analyse clinical features associated antibodies, both line blot (LB) and IP. Myositis-specific myositis-associated autoantibodies were...
Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) may play a pivotal role in associated vasculopathy. The aim present study was to compare NVC alterations with clinical subsets, internal organ involvement, serum VEGF levels cohort selected SSc cases.We studied 44 patients who were evaluated within 3 months from enrollment by NVC, skin score, severity index, pulmonary function tests, carbon...
Progressive pulmonary fibrosis is generally diagnosed when interstitial lung disease progression occurs in the absence of any other cause, and a subset patients with myositis associated may develop progressive fibrosis. Numerous autoantibodies (e.g., against tRNA-synthetase, MDA5, Ro52) increase risk this clinical feature we speculate that serum biomarkers, sought using most sensitive laboratory techniques available (i.e., immunoprecipitation) predict involvement allow early identification...
Abstract Background: Anti-mitochondrial antibodies (AMA) are found in >90% of primary biliary cholangitis patients. Anti-rods/rings (anti-RR) most commonly associated with interferon-α and ribavirin treatment hepatitis C Clinical laboratories routinely screen for AMA anti-RR using indirect immunofluorescence on HEp-2 cells (HEp-2-IFA). Therefore, we sought to establish reference materials use testing. Methods: AMA-positive anti-RR-positive human plasma samples (AMA-REF RR-REF), identified...
Summary Nuclear interferon-inducible protein 16 (IFI16) and anti-IFI16 antibodies have been detected in subjects with several rheumatic diseases, often correlating disease severity, this study we investigated their prevalence clinical associations psoriatic arthritis (PsA) compared to psoriasis (Pso). We tested sera synovial fluids of patients PsA for IFI16 levels by capture enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)G IgA ELISA, radio-immunoprecipitation...
Serum autoantibodies are pivotal for the early detection of systemic autoimmune rheumatic diseases such as Systemic Sclerosis (SSc) and Poly/Dermatomyositis (PM/DM), in some cases associated with organ complications interstitial lung disease (ILD). A paradigmatic example is provided by autoantibody against Eukaryotic Initiation Factor 2B (eIF2B) that has been recently detected SSc.Sera from 118 patients SSc, 8 Poly/Dermatomyositis, 2 overlap SSc/Polymyositis, 4 undifferentiated connective...
Antimitochondrial antibodies (AMAs) are the hallmark of primary biliary cholangitis (PBC) but can be identified also in patients with connective tissue disease, namely, systemic sclerosis (SSc). Protein immunoprecipitation (IP) and IP-Western blot (WB) used to confirm AMA positivity directed at pyruvate dehydrogenase complex (PDC) subunits E1α, E1β, E2/E3, E3BP showing a cytoplasmic reticular pattern indirect immunofluorescence when performed screening setting before onset overt cholestasis...
The phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in pathogenesis psoriatic arthritis (PsA).