A5044464085- Inflammatory Myopathies and Dermatomyositis
- Muscle Physiology and Disorders
- Eosinophilic Disorders and Syndromes
- Genetic Neurodegenerative Diseases
- Skin Diseases and Diabetes
- Neurogenetic and Muscular Disorders Research
- Muscle and Compartmental Disorders
- Peripheral Neuropathies and Disorders
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Parkinson's Disease and Spinal Disorders
- Autoimmune Neurological Disorders and Treatments
- Immunotherapy and Immune Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dysphagia Assessment and Management
- T-cell and B-cell Immunology
- Amyotrophic Lateral Sclerosis Research
- Multiple Sclerosis Research Studies
- Exercise and Physiological Responses
- Aldose Reductase and Taurine
- Hereditary Neurological Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heterotopic Ossification and Related Conditions
- RNA regulation and disease
- Viral Infections and Immunology Research
Universitätsmedizin Göttingen
2016-2025
Medizinische Hochschule Brandenburg Theodor Fontane
2021-2025
University of Göttingen
2015-2025
Immanuel Krankenhaus
2021-2025
Policlinico San Matteo Fondazione
2024
Klinikum Brandenburg
2023
RWTH Aachen University
2018-2022
University Hospital Schleswig-Holstein
2021
University of Lübeck
2021
Medizinische Hochschule Hannover
2021
Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled data. Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results Of 3067 cases, 69% female. most common subtype dermatomyositis (DM) (31%). Smoking more frequent in connective...
CD4+CD25+ regulatory T cells (T reg cells) play a key role in controlling autoimmunity and inflammation. Therefore, therapeutic agents that are capable of elevating numbers or increasing effector functions this cell subset highly desirable. In previous report we showed superagonistic monoclonal antibody specific for rat CD28 (JJ316) expands activates vivo upon short-term vitro culture. Here demonstrate application very low dosages the superagonist into normal Lewis rats is sufficient to...
High-dose glucocorticosteroid hormones are a mainstay in the treatment of relapses multiple sclerosis. We searched for way to deliver ultra high doses glucocorticosteroids CNS rats with experimental autoimmune encephalomyelitis (EAE) using novel formulation polyethylene glycol (PEG)-coated long-circulating liposomes encapsulating prednisolone (predni solone liposomes, PL). 3H-labelled PL showed selective targeting inflamed CNS, where up 4.5-fold higher radioactivity was achieved than healthy...
Distinct interrelationships between inflammation and β-amyloid-associated degeneration, the two major hallmarks of skeletal muscle pathology in sporadic inclusion body myositis (sIBM), have remained elusive. Expression markers relevant for these pathomechanisms were analysed biopsies sIBM, polymyositis (PM), dermatomyositis (DM), dystrophic non-myopathic as controls, cultured human myotubes. By quantitative PCR, a higher upregulation was noted mRNA-expression CXCL-9, CCL-3, CCL-4, IFN-γ,...
Autopsies are an important tool in medicine, dissecting disease pathophysiology and causes of death. In COVID-19, autopsies revealed e.g., the effects on pulmonary (micro)vasculature or nervous system, systemic viral spread, interplay with immune system. To facilitate multicentre autopsy-based studies provide a central hub supporting autopsy centres, researchers, data analyses reporting, April 2020 German COVID-19 Autopsy Registry (DeRegCOVID) was launched. The electronic registry uses...
Abstract Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired methods the derivation of skeletal cells and their utility in tissue engineering with aim to model regeneration dystrophy vitro. Methods Key steps include directed differentiation human embryonic progenitors followed by primary secondary foetal myogenesis into three‐dimensional muscle. To simulate Duchenne muscular (DMD), a...
Sporadic Inclusion Body Myositis (sIBM) is the most common acquired muscle disease in patients above 50 years of age. Apart from inflammation skeletal muscle, overexpression amyloid precursor protein (APP) and intracellular accumulation its proteolytic fragment beta-amyloid play a central role pathogenesis sIBM. In neurodegenerative disorders, similar aggregations aberrant proteins have recently been shown to be susceptible autophagic degradation. Therefore, we analyzed macroautophagy APP...
Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II molecules. Skeletal muscle fibers show high level of constitutive macroautophagy express MHC molecules upon immune activation. We found tumor necrosis factor-α (TNF-α), monokine overexpressed in inflammatory myopathies, led marked up-regulation skeletal myocytes....
To assess safety and feasibility of real-time (RT) MRI for evaluation dysphagia to compare this technique standard assessment by flexible endoscopic swallowing (FEES) videofluoroscopy (VF) in a cohort patients with inclusion body myositis (IBM).Using RT-MRI, FEES, VF, an unselected 20 IBM was studied as index disease uniform dysphagia. Symptoms were explored standardized tools including Swallowing-Related Quality Life Questionnaire (SWAL-QoL), Functional Rating Scale, Patient-Reported...
<h3>Background and Objectives</h3> CSF in antibody-defined autoimmune encephalitis (AE) subtypes shows subtype-dependent degrees of inflammation ranging from rare often mild to frequent robust. AEs with NMDA receptor antibodies (NMDAR-E) leucine-rich glioma-inactivated protein 1 (LGI1-E) represent opposite ends this spectrum: NMDAR-E typically frequent/robust LGI1-E rare/mild inflammation. For a more in-depth analysis, we characterized findings acute, therapy-naive multicentric,...
The apoptosis-inducing effects of i.v. methylprednisolone were investigated as a possible method controlling inflammation in the CNS adoptive transfer-experimental autoimmune encephalomyelitis (AT-EAE) Lewis rats. Two pulses given at peak mild and severe disease. T-cell apoptosis was assessed on spinal cord cross-sections by morphology TUNEL staining. Concentrations measured serum, CSF tissue high-pressure liquid chromatography (HPLC). In EAE, 10 mg/kg increased significantly infiltration...
Interactions between inducible co‐stimulatory molecule (ICOS) and ICOS‐ligand (ICOS‐L) are crucial for T‐cell co‐stimulation, effector cell differentiation memory CD8+ activation. Because in the muscle of patients with sporadic inclusion body myositis (sIBM) clonally expanded T cells invade major histocompatibility complex (MHC) class I‐expressing fibres, we investigated ICOS·ICOS‐L interactions correlated their expression perforin, a marker cytotoxic function by autoinvasive cells. The mRNA...
The present guidelines on dermatomyositis (DM) represent an excerpt from the interdisciplinary S2k myositis syndromes of German Society Neurology (available at www.awmf.org). cardinal symptom in DM is symmetrical proximal muscle weakness. Elevated creatine kinase, CRP or ESR as well electromyography and biopsy also provide important diagnostic clues. Pharyngeal, respiratory, cardiac, neck muscles may be affected. Given that approximately 30% patients develop interstitial lung disease,...
Sporadic inclusion body myositis is a severely disabling myopathy. The design of effective treatment strategies hampered by insufficient understanding the complex disease pathology. Particularly, nature interrelationships between inflammatory and degenerative pathomechanisms in sporadic has remained elusive. In Alzheimer's dementia, accumulation β-amyloid been shown to be associated with upregulation nitric oxide. Using quantitative polymerase chain reaction, an overexpression inducible...