A5103047095- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Autoimmune Neurological Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Complement system in diseases
- Caveolin-1 and cellular processes
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Pneumonia and Respiratory Infections
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Barrier Structure and Function Studies
- Streptococcal Infections and Treatments
- RNA regulation and disease
- S100 Proteins and Annexins
- Child Nutrition and Feeding Issues
- Immune Response and Inflammation
- Lymphoma Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
Klinikum Itzehoe
2021
University of Göttingen
2017-2018
Universitätsmedizin Göttingen
2014
Charité - Universitätsmedizin Berlin
1997-2011
Klinik und Poliklinik für Neurologie
2009
Humboldt-Universität zu Berlin
1997-2006
Freie Universität Berlin
1996
Keeping cholesterol at bay A decline in tissue repair is a universal hallmark of aging. The failure to regenerate myelin sheaths multiple sclerosis lesions contributes chronic progressive disease and disability. Understanding the cause preventing this key goal regenerative medicine. Cantuti-Castelvetri et al. report that self-limiting inflammatory response, which necessary for remyelination occur, maladaptive central nervous system (CNS) old mice (see Perspective by Chen Popko)....
Abstract Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the pathogenicity invasiveness. We tested hypotheses innate immune inflammasome pathway involved fighting pneumococcal pneumonia some invasive types are not recognized by this pathway. human murine mononuclear cells responded to S. expressing hemolytic pneumolysin producing IL-1β. This IL-1β production depended on NOD-like...
Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral in vivo. In the present study we modeled preconditioning mechanisms a neuronal‐enriched culture. Damage was significantly reduced (up 72%) with 1.5 h of oxygen‐glucose deprivation 48–72 before 3 deprivation. Tolerance also elicited by Na + ‐K ‐ATPase inhibition. No damage observed when astroglial or endothelial cells were exposed hypoxia for and 6 h, respectively. We conclude that hypoxic is robust neuronal...
Glioblastoma is an aggressive brain tumor characterized by abnormal blood vasculature that hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis this setting modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated vascular expression was correlated with poor survival clinical cohort patients high-grade astrocytic glioma. Similarly, intracranial growth the GL261 mouse model glioma delayed significantly CD93(-/-)...
<h3>Background and Objectives</h3> CSF in antibody-defined autoimmune encephalitis (AE) subtypes shows subtype-dependent degrees of inflammation ranging from rare often mild to frequent robust. AEs with NMDA receptor antibodies (NMDAR-E) leucine-rich glioma-inactivated protein 1 (LGI1-E) represent opposite ends this spectrum: NMDAR-E typically frequent/robust LGI1-E rare/mild inflammation. For a more in-depth analysis, we characterized findings acute, therapy-naive multicentric,...
To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by colocalization analysis to identify putatively causal genes.We identified 2 independent risk loci harboring significant variants (p < 5 × 10-8, OR ≥ 2.2), 1 on chromosome 15, only LRRK1 gene, 11 centered ACP2 NR1H3 genes...
Serial analysis of gene expression (SAGE) is a powerful method for largescale patterns. SAGE yields digital information on transcript abundance by the use short sequence fragments (tags). Because does not require priori knowledge expressed genes in starting material, can be used discovery. Unfortunately, correct tag-to-gene allocation after remains problematic when tag corresponds to more than one reference database or novel yet uncloned were detected. To overcome this problem, we developed...
Background: Neuralgic amyotrophy (NA) has been described as a possible extrahepatic manifestation of hepatitis E virus (HEV) infection. Usually, HEV-associated NA occurs bilaterally. The clinical characteristics determining the course have still not defined. Methods: In this retrospective multicentric case series, 16 patients with were studied and compared to 176 HEV without in terms their age, sex, ALT levels. Results: Neither gender distribution (75% vs. 67% male) nor age (47 48 years...
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis. While certain pneumococcal serotypes are associated with nasopharyngeal colonization, infections in patients underlying diseases, higher mortality when causing 1, 7F 8 predominantly found invasive diseases that, however, show lower case-fatality rates. We tested the hypotheses that innate immune inflammasome pathway involved fighting some not recognized by this pathway. humane murine mononuclear cells responded...
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis. While certain pneumococcal serotypes are associated with nasopharyngeal colonization, infections in patients underlying diseases, higher mortality when causing 1, 7F 8 predominantly found invasive diseases that, however, show lower case-fatality rates. We tested the hypotheses that innate immune inflammasome pathway involved fighting some not recognized by this pathway. human murine mononuclear cells responded...
<p>CD93-deficiency did not affect vessel density leukocyte infiltration and pericytes proliferation coverage in T241 fibrosarcoma GL261 glioma.</p>
<p>Endothelial polarity in GL261 and T241 vessels.</p>
<p>Description of additional methods and procedures used in the study.</p>
<p>CD93 deficiency did not inhibit s.c. B16.F10 melanoma growth in male and female mice, T241 fibrosarcoma GL261 glioma mice.</p>