A5042743529- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Neurological and metabolic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Fungal Infections and Studies
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Bacterial Infections and Vaccines
- Protein Tyrosine Phosphatases
- Lymphadenopathy Diagnosis and Analysis
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
Charles University
2013-2025
University Hospital in Motol
2016-2024
University Hospital Bonn
2021-2024
Odense University Hospital
2024
University of Southern Denmark
2024
Bielefeld University
2024
University Hospital Schleswig-Holstein
2023
University of Lübeck
2023
Institute of Neuroimmunology of the Slovak Academy of Sciences
2021
Ludwig-Maximilians-Universität München
2021
We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated 27 single-nucleotide polymorphisms (SNPs) the HLA-II region (leading SNP rs2858870 p 1.22 × 10-17 , OR 13.66 [7.50-24.87]). Potential associations, below significance, were found rs72961463 close to doublecortin-like kinase 2...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Its immunopathogenesis has been proposed to include early cerebrospinal fluid (CSF) lymphocytosis, subsequent CNS disease restriction and B cell mechanism predominance. There are limited data regarding T involvement in disease. To contribute current knowledge, we investigated complex chemokines cytokines related functions CSF sera samples from anti-NMDAR patients at...
Background The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be potential biomarker neuropsychiatric involvement SLE (NPSLE). Methods 80 patients with were included. We obtained paired CSF samples from 48 (NPSLE n=32, non-NPSLE n=16) 31 controls. levels NfL determined using ELISA. Results Patients NPSLE demonstrated significantly higher compared the group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05)...
Autoimmune encephalitis (AE) refers to a heterogenous group of inflammatory CNS diseases. Subgroups with specified neural autoantibodies are more homogeneous in presentation, trigger factors, outcome, and response therapy. However, considerable fraction patients has AE features but does not harbor detectable is referred as antibody-negative AE. Our aim was describe clinical features, treatments, outcome cohort comprehensively tested patients.
Patients with ongoing seizures are usually not allowed to drive. The prognosis for seizure freedom is favorable in patients autoimmune encephalitis (AIE) antibodies against NMDA receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), and the gamma-aminobutyric-acid B (GABA
To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by colocalization analysis to identify putatively causal genes.We identified 2 independent risk loci harboring significant variants (p < 5 × 10-8, OR ≥ 2.2), 1 on chromosome 15, only LRRK1 gene, 11 centered ACP2 NR1H3 genes...
Background The possibility to better predict the severity of disease in a patient newly diagnosed with multiple sclerosis would allow treatment strategy be personalized and lead clinical outcomes. Prognostic biomarkers are highly needed. Objective To assess prognostic value intrathecal IgM synthesis, cerebrospinal fluid serum IL-2, IL-6, IL-10, chitinase 3-like 2 neurofilament heavy chains obtained early after onset disease. Methods 58 patients first manifestation were included. After...
Alemtuzumab as a treatment of highly active multiple sclerosis causes rapid decrease in inflammatory activity due the lysis immune cells. Subsequent cytokine release determines infusion-associated reaction that is frequent adverse event alemtuzumab treatment. Recently, serious cardiovascular and thrombotic reactions following infusion have been described. In our study, dynamics coagulation parameters were analyzed 13 patients treated with alemtuzumab. An immediate, significant increase level...
Abstract Background and purpose N ‐methyl‐ d ‐aspartate receptor (NMDAR) leucine‐rich glioma‐inactivated protein 1 (LGI1) encephalitis are important types of autoimmune (AE) with significant morbidity. In this study, we used a proteomic approach in search novel clinically relevant biomarkers these encephalitides. Methods Swedish Czech tertiary neuroimmunology centers collaborated retrospective exploratory study. Fifty‐eight cerebrospinal fluid (CSF) samples 28 patients AE (14 definite NMDAR,...
Abstract Objective Refractory epilepsy may have an underlying autoimmune etiology. Our aim was to assess the prevalence of neural autoantibodies in a multicenter national prospective cohort patients with drug‐resistant undergoing surgery utilizing comprehensive clinical, serologic, and histopathological analyses. Methods We prospectively recruited for refractory focal not caused by brain tumor from centers Czech Republic. Perioperatively, we collected cerebrospinal fluid (CSF) and/or serum...
V současné době se mění pohled na léčbu roztroušené sklerózy. U indikovaných pacientů je cílem nasazení vysoce účinné léčby v rané fázi nemoci. Zvyšuje počet této léčbě i spektrum léčiv. Ofatumumab jedním z účinných léků. Jde o monoklonální protilátku proti CD20 lymfocytům s prokázanou vysokou a rychlou účinností potlačení zánětlivé aktivity, ale částečně progrese onemocnění bez relapsů. Byť dobře tolerován, což umožňuje aplikaci pacientem domácím prostředí, stále jedná lék působící...
Ocrelizumab, jako monoklonální protilátka proti CD 20 lymfocytům, je jedním ze zástupců vysoce účinné léčby (HET - high efficacy therapy). Změna paradigmatu roztroušené sklerózy z eskalační na indukční strategii první léčba) spolu s novými indikačními omezeními úhrady vede k rozšíření spektra pacientů, kterým můžeme tuto léčbu nabídnout již v počátku onemocnění. Více studií potvrdilo, že nasazení HET časných fázích nemoci zlepšuje u indikovaných pacientů prognózu nejen potlačením zánětlivé...
Abstract Objective To investigate the genetic determinants of most common type antibody-mediated autoimmune encephalitis, anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Methods We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls followed by colocalization analysis to identify putatively causal genes. Results identified two independent risk loci harboring significant variants (P < 5 × 10 −8 , OR ≤ 2.2), one on...
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