A5061661448- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Genetics and Neurodevelopmental Disorders
- Vagus Nerve Stimulation Research
- Glioma Diagnosis and Treatment
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Cardiovascular Syncope and Autonomic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Neurological and metabolic disorders
- Intensive Care Unit Cognitive Disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
Mayo Clinic
2016-2025
WinnMed
2010-2025
Mayo Clinic in Arizona
2015-2025
Odense University Hospital
2024
University of Southern Denmark
2024
University Hospital Bonn
2024
Bielefeld University
2024
Mayo Clinic in Florida
2015-2023
Neurology, Inc
2001-2023
University of Minnesota Rochester
2017-2019
<h3>Objective</h3>To further characterize the demographics, outcomes, and prognostic factors for refractory status epilepticus (RSE).<h3>Design</h3>Retrospective analysis of all episodes RSE treated between January 1, 1999, August 30, 2011.<h3>Setting</h3>Neurointensive care unit within a tertiary referral center, Mayo Clinic, Rochester, Minnesota.<h3>Patients</h3>Refractory was defined as generalized convulsive or nonconvulsive (SE) that continued despite initial first- second-line...
<h3>Objective:</h3> To evaluate a trial of immunotherapy as an aid to diagnosis in suspected autoimmune epilepsy. <h3>Method:</h3> We reviewed the charts 110 patients seen at our neurology clinic with seizures chief complaint. Twenty-nine met following inclusion criteria: (1) epilepsy based on presence ≥1 neural autoantibody (n = 23), personal or family history physical stigmata autoimmunity, and frequent medically intractable seizures; (2) initiated 6- 12-week IV methylprednisolone (IVMP),...
To characterize the clinical features and MRI abnormalities of leucine-rich glioma-inactivated 1 (LGI1)-autoantibody (Ab) faciobrachial dystonic seizures (FBDS).Forty-eight patients with LGI1-Ab encephalopathy were retrospectively identified by searching our serologic database from January 1, 2002, to June 2015. Of these, 26 met inclusion criteria for this case series: seropositivity FBDS. In a separate analysis all 48 initially identified, MRIs (n = 26) without 22) FBDS compared 2...
Object The authors reviewed the long-term outcome of focal resection in a large group patients who had intractable partial nonlesional epilepsy, including mesial temporal lobe sclerosis (MTS), and were treated consecutively at single institution. goal this study was to evaluate efficacy epilepsy surgery preoperative factors associated with seizure outcome. Methods This retrospective analysis included 399 consecutive underwent Mayo Clinic Rochester, Minnesota, between 1988 1996. mean age 32 ±...
To determine the prognostic value of an EEG grading scale and clinical outcome treated seizures detected with continuous (cEEG) during therapeutic hypothermia (TH) rewarming post cardiac arrest (CA).Our cohort study retrospectively reviewed electronic medical records cEEGs all patients undergoing TH after CA under protocol over 2 years. cEEG was initiated continued until restoration normothermia (NT). EEGs were graded 1-3 (3 = most severe) using a departmentally developed severity by authors...
Previous studies have established the importance of insular cortex and temporal lobe in cardiovascular autonomic modulation. Some investigators, based on results cortical stimulation response, functional imaging, EEG recordings seizures, lesional studies, suggested that cardiac sympathetic parasympathetic function may be lateralized, with representation lateralized to right insula, parasympathetic, left. These ictal bradycardia is most commonly a manifestation activation left cortex....
To validate predictive models for neural antibody positivity and immunotherapy response in epilepsy.We conducted a retrospective study of epilepsy cases at Mayo Clinic (Rochester-MN; Scottsdale-AZ, Jacksonville-FL) whom autoimmune encephalopathy/epilepsy/dementia autoantibody testing profiles were requested (06/30/2014-06/30/2016). An Antibody Prevalence Epilepsy (APE) score, based on clinical characteristics, was assigned to each patient. Among patients who received immunotherapy, Response...
Patients with normal MR imaging (nonlesional) findings and medically refractory extratemporal epilepsy make up a disproportionate number of nonexcellent outcomes after surgery. In this paper, the authors investigated usefulness intracranial electroencephalography (iEEG) in identification surgical candidates.Between 1992 2002, 51 consecutive patients underwent electrode monitoring. The implantation electrodes was determined by seizure semiology, interictal ictal scalp EEG, SPECT, some PET...
Objective Drug‐resistant seizures are common in patients with leucine‐rich, glioma‐inactivated 1 (LGI1)‐IgG associated and contactin‐associated protein‐like 2 (CASPR2)‐IgG encephalitis. We performed the first randomized double‐blind placebo‐controlled trial to evaluate efficacy of intravenous immunoglobulin (IVIG) reducing seizure frequency. Methods Our enrollment goal was 30 LGI1/CASPR2‐IgG–seropositive adult ≥2 per week. Patients were receive IVIG (0.5g/kg day 1, 1g/kg 2, 0.6g/kg weeks 3...
Objective: The prognostic role of electroencephalography during and after targeted temperature management in postcardiac arrest patients, relatively to other predictors, is incompletely known. We assessed performances toward good poor outcomes, along with recognized predictors. Design: Cohort study (April 2009 March 2016). Setting: Two academic hospitals (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Mayo Clinic, Rochester, MN). Patients: Consecutive comatose adults...
To evaluate the cancer detection rate of whole-body positron emission tomography-computed tomography (PET-CT) in a paraneoplastic neurologic context.Retrospective medical record review.Mayo Clinic, Rochester, Minnesota.Fifty-six consecutive patients with clinically suspected disorders who underwent PET-CT after negative standard evaluations, including CT.Rate detection.Abnormalities suggestive were detected using 22 (39%); 10 (18%) had confirmed histologically. Cancers (limited stage 9 and...
<h3>BACKGROUND AND PURPOSE:</h3> Autoimmune voltage-gated potassium channel complex encephalitis is a common form of autoimmune encephalitis. Patients with seizures due to this commonly have medically intractable epilepsy and may require immunotherapy control seizures. It important that radiologists recognize imaging characteristics type suggest it in the differential diagnosis because seizure etiology likely under-recognized. Our purpose was characterize MR findings patient population....
<h3>Objective:</h3> Small-cell lung carcinoma (SCLC) and limbic encephalitis are recognized γ-aminobutyric acid-B receptor (GABA<sub>B</sub>R) autoantibody accompaniments. We sought to determine in a diagnostic serology laboratory the frequency accompaniments (neurologic, oncologic, serologic) of GABA<sub>B</sub>R–immunoglobulin G (IgG). <h3>Methods:</h3> tested stored serum CSF specimens from 3 patient groups for GABA<sub>B</sub>R-IgG by indirect immunofluorescence on mouse brain tissue...
We aimed to report the pattern of usage and efficacy antiepileptic drugs (AEDs) in patients with autoimmune epilepsy (AE).We retrospectively studied Mayo Clinic's electronic medical record AE which seizures were main presenting feature. Clinical data, including demographics, seizure characteristics, type AED immunotherapy used, presence neural antibody, treatment outcomes, reviewed.The records 252 adult diagnosed encephalitis paraneoplastic disorders reviewed. Seizure was initial...
To compare acute treatment responses and long-term outcome in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis.Retrospective case series of 118 patients with LGI1 encephalitis evaluated at Mayo Clinic across all US sites from May 2008 to 31 March 2019. Patient clinical data were identified analysed through the neuroimmunology laboratory electronic medical record. detection was by cell-based indirect immunofluorescence assay serum, cerebrospinal fluid or both. Clinical outcomes...
To assess the clinical practice applicability of autoimmune encephalitis (AE) criteria (2016).Medical records 538 adults diagnosed with AE or related encephalopathy at Mayo Clinic (not including pure movement disorders) were reviewed and guideline applied.Of patients, 288 male (52%). The median symptom onset age was 55 years (range, 11-97 years; 16 had as children). All other non-AE diagnoses reasonably excluded. Of 361 (67%) met least possible criteria, having all 3 subacute onset; memory...
Data regarding long-term recovery from autoimmune encephalitis (AE) remain limited. This retrospective observational study investigated outcomes in 182 patients who met the 2016 criteria for definite AE. Recovery data were available 172 patients. Follow-up at ≥24 months post-attack 119. trajectory, residual symptoms, outcome predictors and causes of post-AE death assessed. Of patients, 138 (80%) achieved good (modified Rankin Scale (mRS) ≤2) with a median time 4 (95% CI: 2 to 6 months)....
Summary: We performed a retrospective study of 51 consecutive patients who underwent operation for intractable partial epilepsy related to low‐grade intracerebral neoplasms between 1984 and 1990. All had medically refractory seizures mass lesion identified on neuroimaging studies. Lesionectomy was 17 patients, 34 resection corticectomy. Mean postoperative follow‐up 4.4 years (range 2–8 years). Sixty‐six percent were seizure‐free, 88% experienced significant reduction in seizure frequency. In...
Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] poorly understood. The authors performed a multicenter, randomized trial three unique modes VNS, which varied primarily by duty-cycle. results indicate that were equally effective. data support use standard as initial therapy.