A5085312364- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Multiple Sclerosis Research Studies
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging and Analysis
- Neonatal and fetal brain pathology
- Venous Thromboembolism Diagnosis and Management
- Brain Metastases and Treatment
- Transcranial Magnetic Stimulation Studies
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Advanced X-ray and CT Imaging
- Neurological disorders and treatments
- Neural dynamics and brain function
- Radiation Dose and Imaging
- Brain Tumor Detection and Classification
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2016-2025
Karolinska Institutet
2024
Nationwide Children's Hospital
2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Montréal
2024
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Munich School of Philosophy
2023
Hudson Institute
2023
Alzheimer's disease (AD) is a neurodegenerative disorder that prominently affects cerebral connectivity. Assessing the functional connectivity at rest, recent MRI (fMRI) studies reported on existence of resting-state networks (RSNs). RSNs are characterized by spatially coherent, spontaneous fluctuations in blood oxygen level-dependent signal and made up regional patterns commonly involved functions such as sensory, attention, or default mode processing. In AD, network (DMN) affected reduced...
Major depressive disorder (MDD) is characterized by altered intrinsic functional connectivity within (intra-iFC) networks (ICNs), such as the Default Mode- (DMN), Salience- (SN) and Central Executive Network (CEN). It has been proposed that aberrant switching between DMN-mediated self-referential CEN-mediated goal-directed cognitive processes might contribute to MDD, possibly explaining patients' difficulties disengage processing of self-focused, often negatively biased thoughts. Recently,...
In schizophrenia, consistent structural and functional changes have been demonstrated for the insula including aberrant salience processing, which is critical psychosis. Interactions within across default mode central executive network (DMN, CEN) are impaired in schizophrenia. The question arises whether these 2 types of related. Recently, anterior has to control DMN/CEN interactions. We hypothesized that activity schizophrenia associated with an dependence interactions on insular (SN)...
Ischemic stroke of undetermined cause is a major health issue because its high frequency and clinical relevance. Histopathologic analysis human thrombi, retrieved from patients with large-vessel occlusion during mechanical thrombectomy, may provide information about underlying pathologies. This study examines the relationship between causes histological clot composition to identify specific patterns that might help distinguish cryptogenic stroke.Thrombi 145 consecutive were collected...
Background The Thrombolysis in Cerebral Infarction (TICI) scale is the most widely applied scoring system to grade technical results of recanalizing therapies acute ischemic stroke (AIS). TICI 2b and 3 are conventionally subsumed as ‘successful recanalization’. Previous studies reported conflicting for clinical relevance achieving complete (TICI 3) versus ‘almost’ reperfusion 2b). Objective To examine if neurologic outcome differs significantly between patients with AIS middle cerebral...
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We present DeepVesselNet, an architecture tailored to the challenges faced when extracting vessel trees and networks corresponding features in 3-D angiographic volumes using deep learning. discuss problems of low execution speed high memory requirements associated with full networks, high-class imbalance arising from percentage (<3%) voxels, unavailability accurately annotated training data—and offer solutions as building blocks DeepVesselNet. First, we formulate 2-D orthogonal...
Abstract Magnetic resonance imaging (MRI) is an important modality in stroke. Computer based automated medical image processing increasingly finding its way into clinical routine. The Ischemic Stroke Lesion Segmentation (ISLES) challenge a continuous effort to develop and identify benchmark methods for acute sub-acute ischemic stroke lesion segmentation. Here we introduce expert-annotated, multicenter MRI dataset segmentation of subacute lesions ( https://doi.org/10.5281/zenodo.7153326 )....
Textual descriptions of radiologic image findings play a critical role in GPT-4 with vision–based differential diagnosis, underlining the importance radiologist experts even multimodal large language models.
PURPOSE: To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method compare it with dynamic susceptibility-weighted contrast material–enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) patients brain tumors. MATERIALS AND METHODS: Thirty-six histologically proven tumors were examined at 1.5 T. A second version quantitative perfusion by using a single subtraction addition thin-section periodic saturation...
The neurophysiological basis of practice-induced gray matter increase is unclear. To study the relationship changes and neural activation, we conducted a combined longitudinal functional morphometric (voxel-based morphometry) magnetic resonance imaging (MRI) on mirror reading. Compared with normal reading, reading resulted in an activation dorsolateral occipital cortex, medial superior parietal prefrontal as well anterior insula cerebellum. Daily practice 15 min for 2 weeks increased...
In major depressive disorder, episodes reoccur in ∼60% of cases; however, neural mechanisms relapse are poorly understood. Depressive characterized by aberrant topology the brain's intrinsic functional connectivity network, and number is one most important predictors for relapse. this study we hypothesized that specific changes interact with course recurrent disorder. To address hypothesis, investigated which associated patients, independently current symptoms disease duration. Fifty...
In imaging functional connectivity (FC) analyses of the resting brain, alterations FC during unconsciousness have been reported. These results are in accordance with recent electroencephalographic studies observing impaired top-down processing anesthesia. this study, simultaneous records magnetic resonance (fMRI) and electroencephalogram were performed to investigate causality neural mechanisms propofol-induced loss consciousness by correlating fMRI directional (DC)...
Objective: The brain regions that are critically involved in the pathophysiology of anorexia nervosa have not been clearly elucidated. Moreover, decrease cerebral tissue during extreme malnutrition has demonstrated repeatedly nervosa, but data regarding reversibility this conflicting. authors examined region-specific gray matter changes and global volumes recovered patients with nervosa. Method: High-resolution, T1-weighted magnetic resonance imaging (MRI) voxel-based morphometry were...
To investigate whether the functional changes in pain disorder might be reflected by structural brain changes. Pain assessed with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria is characterized persistent distressing chronic at one or more body sites which cannot fully explained a physiological process somatic disorder. Psychological factors are thought to play major role. Recent neuroimaging studies evidenced altered processing patients suffering from...
<h3>BACKGROUND AND PURPOSE:</h3> Periprocedural thrombus fragmentation is a relevant risk in endovascular stroke treatment. Because factors influencing its occurrence are largely unknown, this study addresses potential relationship between histology and clot stability. <h3>MATERIALS METHODS:</h3> Eighty-five patients with anterior circulation treated thrombectomy were included retrospective study. The number location of emboli after retrieving the primary thrombus, maneuvers, TICI scores...
Glioblastoma (GBM) is the most aggressive primary brain tumor and resistant to all therapeutic regimens. Relapse occurs regularly might be caused by a poorly characterized stem cell (TSC) subpopulation escaping therapy. We suggest aldehyde dehydrogenase 1 (ALDH1) as novel marker in human GBM. Using neurosphere formation assay functional method identify TSCs, we show that high protein levels of ALDH1 facilitate established GBM lines. Even single positive cells give rise colonies neurospheres....
Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform disorder according to the DSM-IV criteria. A dysfunction of processing circuits has been suggested one underlying pathophysiological factor. There is accumulating evidence for crucial role affect regulating brain structures such medial frontal cortex in this context. We investigated cerebral noxious heat stimuli objective marker sensation 12 right handed women...
Applying graph theoretical analysis of spontaneous BOLD fluctuations in functional magnetic resonance imaging (fMRI), we investigated whole-brain connectivity 11 healthy volunteers during wakefulness and propofol-induced loss consciousness (PI-LOC). After extraction regional fMRI time series from 110 cortical subcortical regions, applied a maximum overlap discrete wavelet transformation changes the brain's intrinsic spatiotemporal organization. During PI-LOC, observed breakdown...
To compare opportunistic quantitative CT (QCT) with dual energy X-ray absorptiometry (DXA) in their ability to predict incident vertebral fractures. We included 84 patients aged 50 years and older, who had routine including the lumbar spine DXA within a 12-month period (baseline) as well follow-up imaging after at least 12 months or sustained an fracture documented earlier. Patients bone disorders aside from osteoporosis were excluded. Fracture status trabecular mineral density (BMD)...
The neural correlates of anesthetic-induced unconsciousness have yet to be fully elucidated. Sedative and anesthetic states induced by propofol been studied extensively, consistently revealing a decrease frontoparietal thalamocortical connectivity. There is, however, less understanding the effects halogenated ethers on functional brain networks.The authors recorded simultaneous resting-state magnetic resonance imaging electroencephalography in 16 artificially ventilated volunteers during...
<b><i>Background:</i></b> Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated relevance minor HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. <b><i>Methods:</i></b> This retrospective single-center analysis 409 patients MCA occlusion treated ET. Patients'...