A5042099693- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Treatment of Major Depression
- Neurological disorders and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health and Psychiatry
- Heart Rate Variability and Autonomic Control
- Medical Imaging Techniques and Applications
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Atomic and Molecular Physics
- Weber, Simmel, Sociological Theory
- Environmental Policies and Emissions
- Neuroscience and Neuropharmacology Research
- Genomics and Rare Diseases
- Computational Drug Discovery Methods
- EEG and Brain-Computer Interfaces
Technical University of Munich
2013-2024
University of Maryland, Baltimore
2024
Fraunhofer Institute for Wind Energy Systems
2024
University of Lübeck
2024
Ludwig-Maximilians-Universität München
2024
Klinikum rechts der Isar
2013-2023
Isotopen Technologien München (Germany)
2019
München Klinik
2018
Institut de l'Information Scientifique et Technique
2018
Goethe University Frankfurt
2014
Major depressive disorder (MDD) is characterized by altered intrinsic functional connectivity within (intra-iFC) networks (ICNs), such as the Default Mode- (DMN), Salience- (SN) and Central Executive Network (CEN). It has been proposed that aberrant switching between DMN-mediated self-referential CEN-mediated goal-directed cognitive processes might contribute to MDD, possibly explaining patients' difficulties disengage processing of self-focused, often negatively biased thoughts. Recently,...
In major depressive disorder, episodes reoccur in ∼60% of cases; however, neural mechanisms relapse are poorly understood. Depressive characterized by aberrant topology the brain's intrinsic functional connectivity network, and number is one most important predictors for relapse. this study we hypothesized that specific changes interact with course recurrent disorder. To address hypothesis, investigated which associated patients, independently current symptoms disease duration. Fifty...
Abstract Background and Hypothesis Abnormal thalamic nuclei volumes their link to cognitive impairments have been observed in schizophrenia. However, whether how this finding extends the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant volume across examined its potential associations with symptoms. Study Design performed FreeSurfer-based volumetry T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode...
While there is consistent evidence for increased presynaptic dopamine synthesis capacity in the striatum of patients with schizophrenia during psychosis, it unclear whether this also holds psychotic remission. This study investigates striatal altered symptomatic remission positive symptoms, and potential alterations relate to symptoms other than positive, such as cognitive difficulties. Twenty-three according Andreasen, 24 healthy controls underwent 18F-DOPA-PET behavioural-cognitive...
Simultaneous PET/MR/EEG (Positron Emission Tomography - Magnetic Resonance Electroencephalography), a new tool for the investigation of neuronal networks in human brain, is presented here within framework European Union Project TRIMAGE. The trimodal, cost-effective imaging makes use cutting edge technology both PET and MR fields. A novel type magnet (1.5T, non-cryogenic) has been built together with scanner that most advanced photodetectors (i.e., SiPM matrices), scintillators matrices...
Abstract Aberrant dopamine function in the dorsal striatum and aberrant intrinsic functional connectivity (iFC) between distinct cortical networks thalamic nuclei are among most consistent large-scale brain imaging findings schizophrenia. A pathophysiological link these two alterations is suggested by theoretical models based on striatal dopamine’s topographic modulation of cortico-thalamic within cortico-basal-ganglia-thalamic circuits. We hypothesized that links topographically with iFC,...
Abstract The resting‐state human brain is a dynamic system that shows frequency‐dependent characteristics. Recent studies demonstrate coactivation pattern (CAP) analysis can identify recurring states with similar configurations. However, it unclear whether and how CAPs depend on the frequency bands. current study investigated spatial temporal characteristics of in four sub‐bands from slow‐5 (0.01–0.027 Hz), slow‐4 (0.027–0.073 slow‐3 (0.073–0.198 to slow‐2 (0.198–0.25 addition typical...
Abstract Negative symptoms such as anhedonia and apathy are among the most debilitating manifestations of schizophrenia (SZ). Imaging studies have linked these to morphometric abnormalities in 2 brain regions implicated reward motivation: orbitofrontal cortex (OFC) striatum. Higher negative generally associated with reduced OFC thickness, while higher specifically maps striatal volume. However, it remains unclear whether tissue losses a consequence chronic illness its treatment or an...
Abstract A potential pathophysiological mechanism of cognitive difficulties in schizophrenia is a dysregulated cholinergic system. Particularly, the basal forebrain nuclei (BFCN), source cortical innervation, support multiple functions, ranging from attention to decision-making. We hypothesized that BFCN structural integrity altered and associated with patients’ attentional deficits. assessed gray matter (GM) cytoarchitectonically defined region-of-interest 72 patients 73 healthy controls,...
Abstract Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying mechanisms negative symptoms incompletely understood, thereby preventing the development targeted treatments. We hypothesized that schizophrenia during psychotic remission, impaired influences both model-based model-free reward predictions on decision-making (‘reward prediction influence’, RPI) underlie symptoms. focused because might...
Cognitive emotion regulation (CER) enables humans to flexibly modulate their emotions. While local theories of CER neurobiology suggest interactions between specialized brain circuits underlying CER, e.g., in subparts amygdala and medial prefrontal cortices (mPFC), global hypothesize interaction increases among larger functional modules comprising circuits. We tested the hypothesis using graph-based whole-brain network analysis MRI data during aversive emotional processing with without CER....
Abstract The reduction of aversive emotions by a conspecific’s presence—called social buffering—is universal phenomenon in the mammalian world and powerful form human emotion regulation. Animal studies on neural pathways underlying buffering typically examined physiological reactions or regional brain activations. However, direct links between emotional stimuli, distinct processes behavioural outcomes are still missing. Using data 27 female participants, current study delineated large-scale...
Both ongoing local metabolic activity (LMA) and corresponding functional connectivity (FC) with remote brain regions are progressively impaired in Alzheimer's disease (AD), particularly the posterior default mode network (pDMN); however, it is unknown how these impairments interact. It well known that decreasing mean synaptic of a region, i.e., LMA, reduces region's sensitivity to afferent input from other regions, FC.We hypothesized progressive decoupling between LMA FC AD, which linked...
Threat processing, enabled by threat circuits, is supported a remarkably conserved neural architecture across mammals. Threatening stimuli relevant for most species include the of being attacked predator or an aggressive conspecific and pain. Extensive studies in rodents have associated threats pain, attack with distinct circuits subregions amygdala, hypothalamus periaqueductal gray. Bearing mind considerable conservation both anatomy these regions defensive behaviors mammalian species, we...
PET (positron emission tomography) biokinetic modelling relies on accurate quantitative data. One of the main corrections required in imaging to obtain high accuracy is tissue attenuation correction (AC). Incorrect non-uniform PET-AC may result local bias images, and thus relative activity distributions time curves for different regions. MRI (magnetic resonance imaging)-based AC an active area research PET/MRI neuroimaging, where several groups developed last few years methods calculate...
Background: Decision-making alterations are present in psychiatric illnesses like major depressive disorder (MDD), obsessive-compulsive (OCD), and schizophrenia, linked to symptoms of the respective disorders. Understanding unique shared decision-making across these disorders is crucial for early diagnosis treatment, especially given potential comorbidities. Methods: Using two computational modeling approaches - logistic regression hierarchical Bayesian we analyzed model-based model-free a...