A5032677599- Impact of Technology on Adolescents
- Parkinson's Disease Mechanisms and Treatments
- Eating Disorders and Behaviors
- Gambling Behavior and Treatments
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Child Development and Digital Technology
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Sexuality, Behavior, and Technology
- Behavioral Health and Interventions
- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Face Recognition and Perception
- Digital Games and Media
- Cardiovascular Disease and Adiposity
- Bariatric Surgery and Outcomes
- Schizophrenia research and treatment
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Obesity, Physical Activity, Diet
- Decision-Making and Behavioral Economics
- Ginkgo biloba and Cashew Applications
Guangzhou University of Chinese Medicine
2025
Montreal Neurological Institute and Hospital
2015-2023
McGill University
2015-2023
Yale University
2012-2016
University College London
2012
Connecticut Mental Health Center
2012
Miami University
2006
University of Hong Kong
2005
Here we test the hypothesis that neurodegenerative process in Parkinson's disease (PD) moves stereotypically along neural networks, possibly reflecting spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls 57) underwent T1-MRI at entry 1 year later as part Progression Markers Initiative. Over this period, demonstrate significantly greater cortical thinning than parts left occipital bilateral frontal lobes right somatomotor-sensory cortex. Cortical is...
It is becoming increasingly clear that brain network organization shapes the course and expression of neurodegenerative diseases. Parkinson disease (PD) marked by progressive spread atrophy from midbrain to subcortical structures and, eventually, cerebral cortex. Recent discoveries suggest process involves misfolding prion-like propagation endogenous α-synuclein via axonal projections. However, mechanisms translate local "synucleinopathy" large-scale dysfunction remain unknown. Here, we use...
Abstract Parkinson’s disease varies in severity and age of onset. One source this variability is sex. Males are twice as likely females to develop disease, tend have more severe symptoms greater speed progression. However, date, there little information large cohorts on sex differences the patterns neurodegeneration. Here we used MRI clinical from Parkinson Progression Markers Initiative measure structural brain between sexes after regressing out expected effect We derived atrophy maps...
White Matter Hyperintensities (WMHs) are associated with cognitive decline in aging and Alzheimer's disease. However, the pathogenesis of Parkinson's disease (PD) is not as clearly related to vascular causes, therefore role WMHs a marker small-vessel (SVD) PD less clear. Currently, SVD assessed treated independently if WMH major MRI sign has higher impact on patients than healthy controls, pathology needs be priority this population. Here we investigate whether presence leads increased de...
Internet use has become a popular entertainment source and highly integrated into daily life. However, some people display problematic or addictive usage of the Internet. The present study attempts to fill current knowledge gaps regarding at-risk/problematic (ARPIU) its relation various health functioning measures.Online survey data from 755 adults in United States were analyzed using chi-square ANOVAs.The ARPIU group did not differ non-ARPIU with respect substance use. Individuals were,...
A successful class of models link decision-making to brain signals by assuming that evidence accumulates a decision threshold. These accumulation have identified neuronal activity appears reflect sensory and variables drive behavior. More recently, an additional evidence-independent time-variant signal, called urgency, has been hypothesized accelerate decisions in the face insufficient evidence. However, most paradigms tested with fMRI or EEG humans not designed disentangle from urgency....
It has been proposed that the acquisition of drug seeking is related to development conditioned dopamine responses in ventral striatum. As use continues and becomes habit-like, have shown shift dorsal Here, using PET [11C]raclopride method highly personalized cocaine cues, we report first evidence humans response prior onset addiction.
Parkinson's disease pathology is hypothesized to spread through the brain via axonal connections between regions and further modulated by local vulnerabilities within those regions. The resulting changes morphology have previously been demonstrated in both prodromal de novo patients. However, it remains unclear whether pattern of atrophy progression over time similarly explained network-based spreading vulnerability. We address this gap mapping trajectory cortical rates a large, multi-centre...
Abstract Negative symptoms such as anhedonia and apathy are among the most debilitating manifestations of schizophrenia (SZ). Imaging studies have linked these to morphometric abnormalities in 2 brain regions implicated reward motivation: orbitofrontal cortex (OFC) striatum. Higher negative generally associated with reduced OFC thickness, while higher specifically maps striatal volume. However, it remains unclear whether tissue losses a consequence chronic illness its treatment or an...
MRI studies show that obese adults have reduced grey matter (GM) and white (WM) tissue density as well altered WM integrity. Bariatric surgery can lead to substantial weight loss improvements in metabolic parameters, but it remains be examined if induces structural brain changes. The aim of this study was characterize GM changes measured with a longitudinal setting following sleeve gastrectomy, determine whether any are related inflammation cardiometabolic blood markers. 29 participants...
ABSTRACT Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by motor and cognitive deficits. The process thought to move stereotypically from the brainstem up cerebral cortex, possibly reflecting spread of toxic alpha-synuclein molecules. Using large, longitudinal, multi-center database de novo PD patients, we tested whether focal reductions in cortical thickness could be explained disease subcortical “disease reservoir” along brain’s connectome. patients...
Current models of decision-making assume that the brain gradually accumulates evidence and drifts toward a threshold that, once crossed, results in choice selection. These have been especially successful primate research; however, transposing them to human fMRI paradigms has proved it be challenging. Here, we exploit face-selective visual system test whether decoded emotional facial features from multivariate signals during dynamic perceptual task are related parameters computational...
Internet gaming is arguably one of the most popular online activities. Online game play, particularly massive multiplayer role-playing games, can be pleasurable and rewarding However, a subset individuals may exhibit problematic patterns engagement that negatively impact psychosocial well-being. Consistent with disorder being included in Section III recently released fifth edition Diagnostic Statistical Manual Mental Disorders , relatively little research has been performed into disorder....
Abstract It is becoming increasingly clear that brain network organization shapes the course and expression of neurodegenerative diseases. Parkinson’s disease (PD) marked by progressive spread atrophy from midbrain to subcortical structures eventually, cerebral cortex. Recent discoveries suggest process involves misfolding prion-like propagation endogenous α -synuclein via axonal projections. However, mechanisms translate local “synucleinopathy” large-scale dysfunction remain unknown. Here...