A5040001337- Cardiovascular Disease and Adiposity
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Gestational Diabetes Research and Management
- Cardiovascular Health and Disease Prevention
- Mental Health Research Topics
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Effects of Environmental Stressors on Livestock
- Advanced Neuroimaging Techniques and Applications
- Nutrition and Health in Aging
- Birth, Development, and Health
- Obsessive-Compulsive Spectrum Disorders
- Genetic and phenotypic traits in livestock
Université Laval
2014-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015-2024
Natural Sciences and Engineering Research Council
2023
Wild Sheep Foundation
2023
Bureau of Land Management
2023
Federal Highway Administration
2023
Quebec Research and Development Centre
2014-2023
Occupational Cancer Research Centre
2023
Montreal Heart Institute
2015-2021
Montreal Neurological Institute and Hospital
2016-2019
Recent molecular genetic studies have shown that the majority of genes associated with obesity are expressed in central nervous system. Obesity has also been neurobehavioral factors such as brain morphology, cognitive performance, and personality. Here, we tested whether these were heritable variance measured by body mass index (BMI) Human Connectome Project (n = 895 siblings). Phenotypically, cortical thickness findings supported "right hypothesis" for obesity. Namely, increased BMI is...
Objective To determine whether adipocyte diameters from three measurement methods are similarly associated with adiposity measurements and cardiometabolic variables. Methods Surgical samples of omental abdominal subcutaneous adipose tissue were obtained in a sample 60 women (age 35–59 years; body mass index 20.3–41.1 kg/m 2 ). Median diameter the main cell population was determined by collagenase digestion, osmium tetroxide fixation, histological analysis. Adiposity risk factors assessed....
Duchenne muscular dystrophy is a recessive disease due to mutation in the dystrophin gene. Myoblast transplantation permits introduce gene dystrophic muscle fibers. However, success of this approach reduced by short duration regeneration following transplantation, which reduces number hybrid Our aim was verify whether myoblast enhanced blocking myostatin signal with an antagonist, follistatin. Three different approaches were studied overexpress follistatin muscles mdx mice transplanted...
Metabolic disorders associated with obesity could lead to alterations in brain structure and function. Whether these changes can be reversed after weight loss is unclear. Bariatric surgery provides a unique opportunity address questions because it induces marked metabolic improvements which turn may impact the longitudinal fashion. Previous studies found widespread grey matter (GM) white (WM) bariatric surgery. However, findings regarding spontaneous neural activity following surgery, as...
Duchenne muscular dystrophy (DMD) is a recessive disease caused by dystrophin gene mutation. Myoblast transplantation permits to introduce the in dystrophic muscle fibers. However, success of this approach reduced short duration regeneration following transplantation, which reduces number hybrid Myostatin (MSTN) negative regulator skeletal development and responsible for limiting regeneration. It binds with high affinity activin type IIB receptor (ActRIIB). Our aim was verify whether...
Differential DNA methylation is a potential marker of breast cancer risk. Few studies have investigated changes in normal tissue and were largely confounded by field effects. To detect epithelium that are causally associated with occurrence, we used nested case-control study design based on prospective cohort patients diagnosed primary invasive hormone receptor-positive cancer. Twenty contralateral (CBC) matched (1:1) 20 who did not develop CBC relevant risk factors. Differentially...
MRI studies show that obese adults have reduced grey matter (GM) and white (WM) tissue density as well altered WM integrity. Bariatric surgery can lead to substantial weight loss improvements in metabolic parameters, but it remains be examined if induces structural brain changes. The aim of this study was characterize GM changes measured with a longitudinal setting following sleeve gastrectomy, determine whether any are related inflammation cardiometabolic blood markers. 29 participants...
Subcutaneous (SC) adipose tissue stearic acid (18:0) content and stearoyl-CoA desaturase-1 (SCD1)-mediated production of oleic (18:1) have been suggested to be altered in obesity. The objective our study was examine abdominal fatty SCD1 mRNA/protein level women.Fatty determined by capillary gas chromatography SC omental (OM) fat tissues from two subgroups 10 women with either small or large OM adipocytes. Samples additional were used measure mRNA protein expression, total extracellular...
We tested the hypothesis that high lipolytic responsiveness is related to increased expression of ATM genes in human adipose tissues.Omental (OM) and subcutaneous (SC) fat samples were obtained surgically 46 women (age: 47.2 ± 4.7 years, BMI: 26.9 5.2 kg/m(2) ). Body composition distribution measured using dual energy X-ray absorptiometry computed tomography. Lipolysis was by glycerol release mature adipocytes isolated collagenase digestion under basal-, isoproterenol (10(-5) M)-, forskolin...
Introduction PGF2α may be involved in the regulation of adipose tissue function. Objectives 1) To examine release by primary preadipocytes, mature adipocytes and whole explants from subcutaneous omental fat compartments; 2) assess which PGF synthase is most relevant human tissue. Methods Fat samples were obtained surgery women. under stimulation TNF-α, IL-1β or both was measured. Messenger RNA expression levels AKR1B1 AKR1C3 measured RT-PCR cytokine-treated preadipocytes. The effect...