A5042931858- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Esophageal and GI Pathology
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Cardiovascular Disease and Adiposity
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Body Contouring and Surgery
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Intestinal Malrotation and Obstruction Disorders
- Diet, Metabolism, and Disease
- Cardiovascular and exercise physiology
- Hormonal and reproductive studies
- Gastric Cancer Management and Outcomes
- Obesity and Health Practices
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Hormonal Regulation and Hypertension
- Gastrointestinal motility and disorders
- Growth Hormone and Insulin-like Growth Factors
- Pancreatitis Pathology and Treatment
Montreal Heart Institute
2011-2024
Université Laval
2014-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2014-2023
Cegep de Sainte Foy
2018
Hôpital de la Timone
2010
SUNY Downstate Health Sciences University
2003-2010
Weatherford College
2010
State University of New York
2010
University of Aberdeen
2009
The University of Melbourne
2009
OBJECTIVE. Our aim was to compare the prevalence of obesity in 172 children who were aged 2 18 years and born 113 obese mothers (BMI: 31 ± 9 kg/m2) with substantial weight loss after biliopancreatic bypass surgery 45 same-age siblings before maternal (mothers’ BMI: 48 8 current population standards. METHODS. In this case series, >88% follow-up a tertiary referral center, crosssectional office chart telephone data on childhood adolescent weights transformed z scores. RESULTS. After...
Background and Objectives: By studying cardiometabolic risk factors in children born after maternal biliopancreatic diversion bariatric surgery (AMS) compared with those before (BMS), we tested the hypothesis that significant weight loss may modify obesity-related transmitted via intrauterine environment. Design: Anthropometry fasting blood levels were studied 49 mothers who had lost 36 ± 1.8% body sustained for 12 0.8 yr their 111 (54 BMS 57 AMS) aged 2.5–26 yr. Results: AMS lower birth...
To investigate whether bariatric surgery increases the risk of fracture. Retrospective nested case-control study. Patients who underwent in province Quebec, Canada, between 2001 and 2014, selected using healthcare administrative databases. 12 676 patients surgery, age sex matched with 38 028 obese 126 760 non-obese controls. Incidence sites fracture had undergone compared Fracture was also before after (index date) within each group by type from 2006 to 2014. Multivariate conditional Poisson...
We examined 5α-dihydrotestosterone (5α-DHT) inactivation and the expression of several steroid-converting enzymes with a focus on aldoketoreductases 1C (AKR1C), especially AKR1C2, in abdominal adipose tissue men. AKR1C2 is mainly involved conversion potent androgen 5α-DHT to its inactive forms 5α-androstane-3α/β,17β-diol (3α/β-diol). Subcutaneous (s.c.) omental (Om) biopsies were obtained from 21 morbidly obese men undergoing biliopancreatic derivation surgery 11 lean general surgery. mRNA...
Biliopancreatic diversion with duodenal switch (BPD-DS) has long been considered as the bariatric procedure highest peri-operative and long-term complication rate. However, modern care, including laparoscopic staged-approach, significantly reduced rate related to this procedure. The goal of article is provide an overview current outcomes BPD-DS in a high volume centre.All patients who had hand-sewn anastomosis performed between 2011 2015 (N = 566) were reviewed. Data obtained from our...
Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) are multipotent. Beyond potential value of these cells for regenerative medicine, dedifferentiation process itself raises many questions about cellular plasticity pathways implicated in cell behavior. work has been performed with objective obtaining new information on adipocyte dedifferentiation, especially pertaining...
There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little known about impact on aging metabolically active visceral tissue (VAT). Herein, we aimed to test whether accelerates VAT in subjects with severe obesity.A significant and positive correlation between chronological age age, estimated a reduced version Horvath's clock, was found both (r = 0.78, p 9.4 × 10-12) 0.80, 1.1 10-12)....
Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels biliopancreatic diversion with duodenal switch (BPD-DS) than Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This closely associated insulin sensitization. In mice rats, BPD-DS RYGB operations also levels, which are not affected by SG or...