A5003161341- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Dietary Effects on Health
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Protein Hydrolysis and Bioactive Peptides
- Gut microbiota and health
- Mangiferin and Mango Extracts
- Bioinformatics and Genomic Networks
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Meat and Animal Product Quality
- Diabetes Management and Research
Université Laval
2016-2025
Centre de Recherche des Cordeliers
2020
Universidad Complutense de Madrid
2013-2015
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2014
There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little known about impact on aging metabolically active visceral tissue (VAT). Herein, we aimed to test whether accelerates VAT in subjects with severe obesity.A significant and positive correlation between chronological age age, estimated a reduced version Horvath's clock, was found both (r = 0.78, p 9.4 × 10-12) 0.80, 1.1 10-12)....
Abstract Objectives Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation important because some types harbor significant therapeutic potential for diabetes. Methods isolation from jejunum of obese individuals with (ObD) or without (Ob) was obtained a new method sorting. profiles were established by RNA-sequencing first group 14 Ob 13 ObD individuals. lineage densities...
The extent of weight loss among patients undergoing bariatric surgery is highly variable. Herein, we tested the contribution genetic background to such interindividual variability after biliopancreatic diversion with duodenal switch.Percentage excess body (%EBWL) was monitored in 865 over a period 48 months surgery, and two polygenic risk scores were constructed 186 11 (PRS186 PRS11) single nucleotide polymorphisms previously associated mass index (BMI).The accuracy %EBWL logistic prediction...
Consumption of red raspberries has been reported to exert acute beneficial effects on postprandial glycemia, insulinemia, triglyceridemia, and cytokine levels in metabolically disturbed subjects. In a two-arm parallel-group, randomized, controlled trial, 59 subjects with overweight or abdominal obesity slight hyperinsulinemia hypertriglyceridemia were randomized consume 280 g/day frozen maintain their usual diet for 8 weeks. Primary analyses measured metabolic differences between the groups....
The aim of this exploratory study was to evaluate the gut microbial signatures distinct trimethylamine N-oxide (TMAO) responses following raspberry consumption. Investigations were carried out in 24 subjects at risk developing metabolic syndrome who received 280 g/day frozen raspberries for 8 weeks. Blood and stool samples collected weeks 0 8. Inter-individual variability plasma TMAO levels analyzed, 7 excluded due noninformative signals 17 kept analysis further stratified according their...
Catch-up growth has been associated with the appearance of metabolic dysfunctions such as obesity and type 2 diabetes in adulthood. Because entero-insular axis is critical to glucose homeostasis control, we explored relevance incretins glucose-dependent insulinotropic polypeptide (GIP) glucagon-like peptide-1 (GLP-1) development these pathologies. Offspring rat dams fed ad libitum (control [C]) or 65% food-restricted during pregnancy suckling time (undernourished [U]) were weaned onto a...
Abstract Background Blueberries contain high levels of polyphenolic compounds with in vitro antioxidant capacities. Their consumption has been associated improved vascular and metabolic health. Purpose The objective was to examine the effects blueberry supplement on syndrome (MetS) parameters potential underlying mechanisms action. Methods A randomized double-blind placebo-controlled intervention trial conducted adults at risk developing MetS. Participants consumed 50 g daily either a...
<b><i>Aims:</i></b> To test the potential association of cytosine-phosphate-guanine dinucleotides (CpG)-single-nucleotide polymorphisms (SNPs) located within actin-related protein 2/3 complex subunit 3 (<i>ARPC3</i>), a gene recently linked to adipogenesis and lipid accumulation, with metabolic syndrome (MetS) features in severely obese patients. <b><i>Methods:</i></b> Prioritized SNPs <i>ARPC3</i> locus were genotyped...
Abstract Maternal malnutrition plays a critical role in the developmental programming of later metabolic diseases susceptibility offspring, such as obesity and type 2 diabetes. Because liver is major organ that produces supplies blood glucose, we aimed at defining potential glycogen autophagy glucose metabolism disturbances. To this end, newborns were obtained from pregnant Wistar rats fed ad libitum with standard diet or 65% food-restricted during last week gestation. We found...
Many studies show that the intake of raspberries is beneficial to immune-metabolic health, but responses individuals are heterogeneous and not fully understood.In a two-arm parallel-group, randomized, controlled trial, outcomes plasma metabolite levels were analyzed before after an 8-week red raspberry consumption. Based on partial least squares discriminant analysis (PLS-DA) xenobiotic levels, adherence intervention was first evaluated. A second PLS-DA followed by hierarchical clustering...
The TOMM20 gene was previously identified as differentially expressed and methylated between severely obese subjects with without metabolic syndrome (MS). Since complications do not affect all patients to the same extent, aim of this study identify methylation quantitative trait loci (meQTL) potentially associated MS-related within locus. Methylation profiling, SNP genotyping meQTL association tests (general linear models) were performed in a population 48 subjects. Genotyping extended...
This study aimed to explore the impact of daily mango consumption (Mangifera indica) on cardiometabolic health and gut microbiota in individuals with overweight obesity. Changes variables, diversity composition, physical activity habits, dietary intakes were assessed 8 males 19 females obesity who consumed 280 g/day pulp for weeks. There no significant changes body weight, waist circumference, or plasma lipid levels. However, after consuming mangos weeks, participants showed a 3.5% reduction...
<b><i>Introduction:</i></b> The consumption of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) has been reported to have beneficial health effects, notably, by reducing plasma triglyceride levels. Nonetheless, a concomitant decrease in insulin sensitivity also observed, but is highly variable among subjects. Herein, we aimed determine the importance genetic background interindividual variability response following an n-3 PUFA supplementation....
Little is known about the impact of mango consumption on metabolic pathways assessed by changes in gene expression. In this single-arm clinical trial, cardiometabolic outcomes and expression levels whole blood samples from 26 men women were examined at baseline after 8 weeks differential determined. Based profiles, partial least squares discriminant analysis followed hierarchical clustering used to classify participants into subgroups response differences following intervention tested. Two...
Abstract Background We previously built a genetic risk score (GRS) highly predictive of the plasma triglyceride (TG) response to an omega-3 fatty acid (n-3 FA) supplementation from marine sources. The objective present study was test potential this GRS predict TG responsiveness with either eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids in Comparing EPA DHA (ComparED) Study. Methods ComparED Study is double-blind, controlled, crossover trial, participants randomized three supplemented...