Charles Couillard

ORCID: 0000-0002-6281-8663
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About
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Research Areas
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Adipokines, Inflammation, and Metabolic Diseases
  • Antioxidant Activity and Oxidative Stress
  • Nutritional Studies and Diet
  • Lipoproteins and Cardiovascular Health
  • Adipose Tissue and Metabolism
  • Lipid metabolism and disorders
  • Phytochemicals and Antioxidant Activities
  • Regulation of Appetite and Obesity
  • Obesity, Physical Activity, Diet
  • Cardiovascular Health and Disease Prevention
  • Nutrition, Genetics, and Disease
  • Consumer Attitudes and Food Labeling
  • Liver Disease Diagnosis and Treatment
  • Cancer, Lipids, and Metabolism
  • Pharmacology and Obesity Treatment
  • Biochemical Analysis and Sensing Techniques
  • Tea Polyphenols and Effects
  • Diet, Metabolism, and Disease
  • Hormonal and reproductive studies
  • Diet and metabolism studies
  • Blood Pressure and Hypertension Studies
  • Diabetes Management and Research
  • Vitamin C and Antioxidants Research
  • Diabetes Treatment and Management

Université Laval
2014-2023

Public Safety Canada
2012

University of Ottawa
2012

Centre Hospitalier Départemental Vendée
2007-2008

Roche (France)
2007-2008

Centre hospitalier universitaire de Québec
1998-2005

Indiana University Bloomington
2000-2001

University of Minnesota
2000-2001

Texas A&M University
2000-2001

Pennington Biomedical Research Center
2000-2001

Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used screening tools for identification of men characterized by a metabolic triad nontraditional risk factors (elevated insulin apolipoprotein [apo] B small, dense LDL particles). Methods Results —Results (study 1) conducted on 185 healthy indicate large proportion (>80%) with values ≥90 cm elevated TG levels (≥2.0 mmol/L)...

10.1161/01.cir.102.2.179 article EN Circulation 2000-07-11

<h3>Background</h3> Total cholesterol (TC)/high-density lipoprotein (HDL-C) and low-density (LDL-C)/HDL-C ratios are used to predict ischemic heart disease risk. There is, however, no consensus on which of these 2 indices is superior. The objective the present study was evidence that LDL-C/HDL-C ratio may underestimate risk in overweight hyperinsulinemic patients with high triglyceride (TG)–low HDL-C dyslipidemia. <h3>Methods</h3> A total 2103 middle-aged men whom measurements metabolic...

10.1001/archinte.161.22.2685 article EN Archives of Internal Medicine 2001-12-10

Abdominal obesity is associated with numerous metabolic alterations, such as hypertriglyceridemia and low levels of high density lipoprotein (HDL) cholesterol. However, compared abdominally obese white individuals, black individuals have been characterized by higher plasma HDL cholesterol levels, suggesting that the impact abdominal fat accumulation on lipoprotein-lipid profile may differ among ethnic groups. Therefore, we associations between body fatness, visceral adipose tissue (AT)...

10.1161/01.atv.20.8.1932 article EN Arteriosclerosis Thrombosis and Vascular Biology 2000-08-01

Abstract —High density lipoprotein (HDL) cholesterol concentrations have been shown to increase with regular endurance exercise and, therefore, can contribute a lower risk of coronary heart disease in physically active individuals compared sedentary subjects. Although low HDL levels are frequently observed combination hypertriglyceridemia, some may be characterized by isolated hypoalphalipoproteinemia, ie, the absence elevated triglyceride (TG) concentrations. The present study responses...

10.1161/hq0701.092137 article EN Arteriosclerosis Thrombosis and Vascular Biology 2001-07-01

Although metabolic disturbances are often observed in obese patients, increased accumulation of visceral adipose tissue (AT) has been shown to be more closely associated with high fasting triglyceride (TG) and insulin levels as well low HDL cholesterol concentrations than excess body fatness per se. Interestingly, the concentration plasma TGs an important determinant magnitude duration postprandial TG response. Yet little is known about respective contributions obesity versus AT variation...

10.2337/diabetes.47.6.953 article EN Diabetes 1998-06-01

Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and low HDL-cholesterol concentrations are common features of a plurimetabolic syndrome, which increases the risk coronary artery disease. Although it has been proposed that development atherosclerosis through alterations in plasma lipid levels could be postprandial phenomenon, most studies on gender differences lipoprotein-lipid have reported fasting levels. Therefore, aim our study was to examine response triglyceride-rich...

10.1161/01.atv.19.10.2448 article EN Arteriosclerosis Thrombosis and Vascular Biology 1999-10-01

Abstract Obesity has been associated with alterations in plasma steroid hormone concentrations men. Older men present an altered profile compared to younger individuals, and increase body fatness changes adipose tissue (AT) distribution are noted advancing age. Thus, there is a need examine the relative importance of increased AT age sex hormone-binding globulin levels We, therefore, investigated relationships among age, fatness, distribution, group 217 Caucasian (mean ± sd, 36.2± 14.9 yr)...

10.1210/jcem.85.3.6427 article EN The Journal of Clinical Endocrinology & Metabolism 2000-03-01

OBJECTIVE: Age-related differences in body fat and, more specifically, the accumulation of abdominal visceral adipose tissue (AT) were examined as potential covariates age-related difference metabolic profile predictive cardiovascular disease (CVD) risk observed young, compared with middle-aged, premenopausal women. RESEARCH DESIGN AND METHODS: Body composition, AT distribution, plasma lipoprotein-lipid levels, glucose tolerance, and insulin concentrations assessed a sample 122 young women...

10.2337/diacare.22.9.1471 article EN Diabetes Care 1999-09-01

Reduced plasma HDL cholesterol concentration has been associated with an increased risk of coronary heart disease. However, a low is usually not observed as isolated disorder because this condition often accompanied by additional metabolic alterations. The objective study was to document the relevance assessing particle size another feature atherogenic dyslipidemia found among subjects visceral obesity and insulin resistance. For that purpose, average computed calculating integrated using...

10.1016/s0022-2275(20)31529-7 article EN cc-by Journal of Lipid Research 2001-12-01

Context: It has been suggested that oxidative stress and endothelial dysfunction could play a role in the higher cardiovascular disease risk noted abdominally obese population. Objective: The objective of this study was to describe associations between abdominal fat accumulation, stress, men. Design: A complete physical metabolic profile assessed group 56 men covering wide range adiposity plasma oxidized low-density lipoprotein (OxLDL), soluble intercellular adhesion molecule-1, vascular...

10.1210/jc.2004-2438 article EN The Journal of Clinical Endocrinology & Metabolism 2005-12-01

The consumption of polyphenols in green tea has been associated with beneficial health effects. Although are unstable the intestinal environment, they may be protected by interactions dairy proteins during digestion. objectives this study were to evaluate effect a extract on digestibility different matrices and monitor antioxidant activity these or without digestion simulated gastrointestinal environment. Milk, yogurt cheese similar fat-to-protein ratios subjected Matrix degradation, protein...

10.1039/c4fo00203b article EN Food & Function 2014-08-19

Abstract Objective: Abdominal obesity is associated with a fasting proinflammatory condition. However, not much known of the potential variations in circulating inflammatory markers after food intake. The purpose present study was to examine postprandial changes plasma tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, and C‐reactive protein (CRP) concentrations men their associations fat distribution metabolic profile variables. Research Methods Procedures: Thirty‐eight were given high‐fat...

10.1038/oby.2006.201 article EN Obesity 2006-10-01

A low HDL-cholesterol concentration is an independent risk factor for CVD. Studies have suggested that flavonoid consumption may be cardioprotective, and a favourable impact on circulating concentrations has been to partially explain this association. The aim of the present study was determine effect consuming increasing daily doses low-calorie cranberry juice cocktail (CJC) plasma lipid profile abdominally obese men. For purpose, thirty men (mean age 51 (SD 10) years) consumed CJC during...

10.1079/bjn20061814 article EN British Journal Of Nutrition 2006-08-01

Elevated circulating concentrations of oxidized LDL (OxLDL) and cell adhesion molecules are considered to be relevant markers oxidative stress endothelial activation which implicated in the development CVD. On other hand, it has been suggested that dietary flavonoid consumption may cardioprotective through possible favourable impacts on particle oxidation activation. The present study was undertaken determine effect daily low-calorie cranberry juice cocktail plasma OxLDL, intercellular...

10.1017/s0007114507811986 article EN British Journal Of Nutrition 2007-08-31

High fruit and vegetable (FAV) intake is associated with a lower prevalence of chronic diseases. Identifying the ideal number FAV servings needed to reduce disease risk is, however, difficult because biases inherent common self-report dietary assessment tools. The aim our study was examine associations between daily plasma carotenoid concentrations in men women enrolled series fully controlled interventions. We compiled analysed data from group 155 109 who participated six interventions...

10.1017/s0007114516003056 article EN British Journal Of Nutrition 2016-08-30
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