Jean‐Philippe Després

ORCID: 0000-0003-3162-787X
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About
Contact & Profiles
Research Areas
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Diverse Music Education Insights
  • Adipose Tissue and Metabolism
  • Neuroscience and Music Perception
  • Diet and metabolism studies
  • Adipokines, Inflammation, and Metabolic Diseases
  • Liver Disease Diagnosis and Treatment
  • Pharmacology and Obesity Treatment
  • Lipoproteins and Cardiovascular Health
  • Cancer, Lipids, and Metabolism
  • Cardiovascular Disease and Adiposity
  • Obesity, Physical Activity, Diet
  • Regulation of Appetite and Obesity
  • Music Therapy and Health
  • Children's Physical and Motor Development
  • Music Technology and Sound Studies
  • Obesity and Health Practices
  • Muscle metabolism and nutrition
  • Lipid metabolism and disorders
  • Metabolism, Diabetes, and Cancer
  • Diabetes Treatment and Management
  • Hormonal and reproductive studies
  • Youth Development and Social Support
  • Autism Spectrum Disorder Research
  • Lipid metabolism and biosynthesis

Université Laval
2015-2024

Université de Montréal
2013-2018

Université du Québec à Montréal
2013-2018

University of Cambridge
2016

Montreal Heart Institute
1971-2014

University of Leeds
2013

Institut Universitaire de Cardiologie et de Pneumologie de Québec
2013

Canadian University Music Society
2013

Toronto Public Health
2012

Endocrinology Research Center
2003

Although metabolic disturbances are often observed in obese patients, increased accumulation of visceral adipose tissue (AT) has been shown to be more closely associated with high fasting triglyceride (TG) and insulin levels as well low HDL cholesterol concentrations than excess body fatness per se. Interestingly, the concentration plasma TGs an important determinant magnitude duration postprandial TG response. Yet little is known about respective contributions obesity versus AT variation...

10.2337/diabetes.47.6.953 article EN Diabetes 1998-06-01

OBJECTIVE: Age-related differences in body fat and, more specifically, the accumulation of abdominal visceral adipose tissue (AT) were examined as potential covariates age-related difference metabolic profile predictive cardiovascular disease (CVD) risk observed young, compared with middle-aged, premenopausal women. RESEARCH DESIGN AND METHODS: Body composition, AT distribution, plasma lipoprotein-lipid levels, glucose tolerance, and insulin concentrations assessed a sample 122 young women...

10.2337/diacare.22.9.1471 article EN Diabetes Care 1999-09-01

The aim of this study was to determine the contribution physical activity and abdominal obesity variation in inflammatory biomarkers incident coronary heart disease (CHD) a European population. In prospective case–control nested Prospective Investigation into Cancer Nutrition-Norfolk cohort, we examined associations between circulating levels or C-reactive protein, myeloperoxidase (MPO), secretory phospholipase A2 (sPLA2), lipoprotein-associated (Lp-PLA2), fibrinogen, adiponectin, waist...

10.1093/eurheartj/ehp010 article EN European Heart Journal 2009-02-18

Eating behaviour traits are associated with body weight variations in adults. The Three-Factor Questionnaire (TFEQ) measures cognitive restraint, disinhibition and hunger, as well their corresponding subscales, e.g. rigid flexible control. TFEQ has not been widely used adolescents to investigate eating weight. aim of the present study was assess whether were BMI male female adolescents. Sixty (thirty females thirty males; mean age 15·0 ( sd 2·4) years) from Québec Family Study completed 3 d...

10.1017/s0007114510001662 article EN British Journal Of Nutrition 2010-05-07

Freshly isolated human adipocytes showed specific uptake of 125I-labeled high density lipoprotein (HDL2 and HDL3), a portion which could be released by subsequent incubation with excess unlabeled ligand. To study the mechanism HDL binding, sucrose gradient-purified adipocyte plasma membranes were incubated radioiodinated particles under equilibrium conditions in absence (total binding) or presence (nonspecific 100-fold Specific binding HDL2 HDL3, calculated subtracting nonspecific from total...

10.1172/jci111893 article EN Journal of Clinical Investigation 1985-06-01

Differences in cardiovascular risk factors across Europe provide an opportunity to examine the impact of adiposity on frequency diabetes and disease (CVD).The International Day for Evaluation Abdominal obesity (IDEA) study evaluated prevalence abdominal obesity, elevated body mass index (BMI), other cardiometabolic among primary care patients. predicted increased risk, despite socio-economic, demographic, factor differences. Cardiovascular was at least two-fold more frequent Eastern vs....

10.1093/eurheartj/ehp371 article EN European Heart Journal 2009-09-23

To further understand the factors involved in regulation of high plasma triglyceride (TG) or low density lipoprotein cholesterol (HDL-C) levels, three groups male subjects (normal TG with HDL-C normal and levels) were compared a sample normolipemic men levels. Mean age was 34 years (range, 20-42 years), none had levels > 4.0 mmol/l familial hypercholesterolemia. Both higher body mass index, waist circumference, waist-to-hip circumferences ratio, ratio abdominal to femoral adipose tissue...

10.1161/01.atv.13.1.33 article EN Arteriosclerosis and Thrombosis A Journal of Vascular Biology 1993-01-01
Daniel Jakson Ian R. White John B. Kostis A. C. Wilson Aaron R. Folsom and 95 more Kevin Chien‐Chang Wu Lloyd E. Chambless U. Benderley Uri Goldbourt Johann Willeit Stefan Kiechl J. W. G. Yarnell P M Sweetnam P. C. Elmwood M. Cushman Bruce M. Psaty Russell P. Tracy Anne Tybjærg‐Hansen F. Haverkate Moniek P.M. de Maat Simon G. Thompson F.G.R. Fowkes Amanda Lee Fraser Smith Veikko Salomaa Kennet Harald Vesa Rasi Elina Vahtera Jari Lahti R. D'Agostino W B Kannel Peter W.F. Wilson Geoffrey H. Tofler Daniel Levy Roberto Marchioli Franco Valagussa Annika Rosengren L. Wilhemsen Georgios Lappas H. Eriksson Peter Cremer D. Nagel J. David Curb Beatriz L. Rodríguez Ken Yano J T Salonen K. Nyyssönen Tomi‐Pekka Tuomainen Bo Hedblad Gunnar Engström G. Berglund Hannelore Loewel Wolfgang Köenig Hans‐Werner Hense T W Meade J. A. Copper Bianca De Stavola Clare Knottenbelt G. J. Miller Jackie A. Cooper K. A. Bauer R D Rosenberg Shin-ichi Sato Akihiko Kitamura Yusuke Naito Hiroyasu Iso T. Palosou Pierre Ducimetière Philippe Amouyel Dominique Arveiler A. E. Evans Jean Ferrières I. Juhan‐Vague A. Bingham H. Schulte Gerd Assmann Bernard Cantin Benoı̂t Lamarche Jean‐Philippe Després Gilles R. Dagenais Hugh Tunstall‐Pedoe G.D.O. Lowe Mark Woodward Y. Ben-Shlomo George Davey Smith Vincenzo Palmieri J. L. Yeh Alicja R. Rudnicka Patrick J. Brennan P. Ridker F. Rodeghiero Alberto Tosetto J. Shepherd Donna O. Lowe I. Ford Michele Robertson Eric J. Brunner M. J. Shipley E. J.M. Fesken Emanuele Di Angelantonio

One difficulty in performing meta-analyses of observational cohort studies is that the availability confounders may vary between cohorts, so some cohorts provide fully adjusted analyses while others only partially analyses. Commonly, association an exposure and disease either are restricted to with full confounder information, or use all but do not adjust for confounding. We propose using a bivariate random-effects meta-analysis model information from available still adjusting potential...

10.1002/sim.3540 article EN other-oa Statistics in Medicine 2009-02-16

To determine the effect of obesity on size distribution fat cell populations in human adipose tissue, omental tissue biopsies were obtained from lean, moderately obese, and massively obese patients. The distributions adipocytes lean tissues examined by scanning electron microscopic method bimodal, consisting very small cells mature cells, contrast to collagenase-derived isolated that showed only large cells. population represented 21 26% total number both groups. In contrast, preparations...

10.1016/s0022-2275(20)38388-7 article EN cc-by Journal of Lipid Research 1989-02-01
Lisa Pennells Ian R. White Angela Wood Stephen Kaptoge Nadeem Sarwar and 95 more John B. Kostis A. C. Wilson Aaron R. Folsom Lloyd E. Chambless Michal Benderly Uri Goldbourt Johann Willeit Stefan Kiechl J. W. G. Yarnell P M Sweetnam Mary Cushman Bruce M. Psaty Russell P. Tracy Anne Tybjærg‐Hansen F. Haverkate Moniek P.M. de Maat Simon G. Thompson F.G.R. Fowkes Amanda Lee Fraser Smith Veikko Salomaa Kennet Harald Elina Vahtera Pekka Jousilahti Juha Pekkanen Ralph B. D’Agostino W B Kannel Peter W.F. Wilson Geoffrey H. Tofler Daniel Levy Roberto Marchioli Franco Valagussa Annika Rosengren Lars Wilhelmsen Georgios Lappas H. Eriksson Peter Cremer D. Nagel J. David Curb Beatriz L. Rodríguez Ken Yano Jukka T. Salonen K. Nyyssönen Tomi‐Pekka Tuomainen Bo Hedblad Gunnar Engström G. Berglund Hannelore Loewel Wolfgang Köenig Hans‐Werner Hense T W Meade J. Cooper Bianca De Stavola Clare Knottenbelt G. J. Miller J. A. Copper K. A. Bauer Robert Rosenberg Shin-ichi Sato Akihiko Kitamura Yusuke Naito Hiroyasu Iso Vesa Rasi Timo Palosuo Pierre Ducimetière Philippe Amouyel Dominique Arveiler A. E. Evans Jean Ferrières I. Juhan‐Vague A. Bingham H. Schulte Gerd Assmann Bernard Cantin Benoı̂t Lamarche Jean‐Philippe Després Gilles R. Dagenais Hugh Tunstall‐Pedoe G.D.O. Lowe Mark Woodward Yoav Ben‐Shlomo George Davey Smith Vincenzo Palmieri J. L. Yeh Paul V. Brennan Alicja R. Rudnicka Jackie A. Cooper P. Ridker F. Rodeghiero Alberto Tosetto J. Shepherd Ian Ford Michele Robertson Eric J. Brunner M Shipley

Many measures have been proposed to summarize the prognostic ability of Cox proportional hazards (CPH) survival model, although none is universally accepted for general use. By contrast, little work has done stratified CPH model; such would be useful in analyses individual participant data from multiple studies, multi-centre and single study analysis where stratification used avoid making assumptions hazards. We chosen three developed unstratified model (Schemper Henderson's V , Harrell's...

10.1002/sim.3378 article EN Statistics in Medicine 2008-09-24
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